SOX21
Transkripcijski faktor SOX-21 je protein koji je kod ljudi kodiran genom SOX21 [5][6] Član je porodice transkripcijskih faktora Sox .
Aminokiselinska sekvenca
urediDužina polipeptidnog lanca je 276 aminokiselina, a molekulska težina 28.580 Da.[7]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MSKPVDHVKR | PMNAFMVWSR | AQRRKMAQEN | PKMHNSEISK | RLGAEWKLLT | ||||
| ESEKRPFIDE | AKRLRAMHMK | EHPDYKYRPR | RKPKTLLKKD | KFAFPVPYGL | ||||
| GGVADAEHPA | LKAGAGLHAG | AGGGLVPESL | LANPEKAAAA | AAAAAARVFF | ||||
| PQSAAAAAAA | AAAAAAGSPY | SLLDLGSKMA | EISSSSSGLP | YASSLGYPTA | ||||
| GAGAFHGAAA | AAAAAAAAAG | GHTHSHPSPG | NPGYMIPCNC | SAWPSPGLQP | ||||
| PLAYILLPGM | GKPQLDPYPA | AYAAAL |
- Simboli
Funkcija
urediU embrionu kokoši, Sox21 promovira neuronsku ćelijskudiferencijaciju, suzbijajući aktivnost Sox1, Sox2 i Sox3, koji održavaju neuronske ćelije u nediferenciranom stanju.[8]
SOX21 nokaut-miševs eksprimira gubitak dlake, počevši od 11. dana nakon porođaja. Ponovni rast započeo je nekoliko dana kasnije, ali je uslijedio ponovni gubitak dlake. Sox21 je također eksprimiran i u kutikulaama dlake kod ljudi, pa bi varijante gena Sox21 mogle biti odgovorne za neka stanja opadanja kose.[9]
Također pogledajte
urediReference
uredi- ^ a b c GRCh38: Ensembl release 89: ENSG00000125285 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000061517 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Malas S, Duthie S, Deloukas P, Episkopou V (Sep 1999). "The isolation and high-resolution chromosomal mapping of human SOX14 and SOX21; two members of the SOX gene family related to SOX1, SOX2, and SOX3". Mammalian Genome. 10 (9): 934–7. doi:10.1007/s003359901118. PMID 10441749. S2CID 27862567.
- ^ "Entrez Gene: SOX21 SRY (sex determining region Y)-box 21".
- ^ "UniProt, Q9Y651". Pristupljeno 11. 9. 2017.
- ^ Sandberg M, Källström M, Muhr J (Aug 2005). "Sox21 promotes the progression of vertebrate neurogenesis". Nature Neuroscience. 8 (8): 995–1001. doi:10.1038/nn1493. PMID 15995704. S2CID 25515445.
- ^ Kiso M, Tanaka S, Saba R, Matsuda S, Shimizu A, Ohyama M, Okano HJ, Shiroishi T, Okano H, Saga Y (Jun 2009). "The disruption of Sox21-mediated hair shaft cuticle differentiation causes cyclic alopecia in mice". Proceedings of the National Academy of Sciences of the United States of America. 106 (23): 9292–7. Bibcode:2009PNAS..106.9292K. doi:10.1073/pnas.0808324106. PMC 2695080. PMID 19470461. Sažetak – Reuters UK.
Dopunska literatura
uredi- Schepers GE, Teasdale RD, Koopman P (Aug 2002). "Twenty pairs of sox: extent, homology, and nomenclature of the mouse and human sox transcription factor gene families". Developmental Cell. 3 (2): 167–70. doi:10.1016/S1534-5807(02)00223-X. PMID 12194848.
- Hartley JL, Temple GF, Brasch MA (Nov 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
- Cremazy F, Soullier S, Berta P, Jay P (Nov 1998). "Further complexity of the human SOX gene family revealed by the combined use of highly degenerate primers and nested PCR". FEBS Letters. 438 (3): 311–4. doi:10.1016/S0014-5793(98)01294-0. PMID 9827568. S2CID 551497.
- Stevanović M, Lovell-Badge R, Collignon J, Goodfellow PN (Dec 1993). "SOX3 is an X-linked gene related to SRY". Human Molecular Genetics. 2 (12): 2013–8. doi:10.1093/hmg/2.12.2013. PMID 8111369.
- Denny P, Swift S, Brand N, Dabhade N, Barton P, Ashworth A (Jun 1992). "A conserved family of genes related to the testis determining gene, SRY". Nucleic Acids Research. 20 (11): 2887. doi:10.1093/nar/20.11.2887. PMC 336939. PMID 1614875.