SLC9A4
Niskofinitetni natrij-glukozni kotransporter, znan i kao natrij/glukoza kotransporter 3 (SGLT3) ili član 4 poriodice 5 rastvornih nosača (SLC5A4) jest protein koji je kod ljudi kodiran genom SLC5A4 sa hromosoma 2.[5][6][7] Funkcionira kao senzor šećera.
Aminokiselinska sekvenca
urediDužina polipeptidnog lanca je 659 aminokiselina, a molekulska težina 72.456 Da.[8]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MASTVSPSTI | AETPEPPPLS | DHIRNAADIS | VIVIYFLVVM | AVGLWAMLKT | ||||
| NRGTIGGFFL | AGRDMAWWPM | GASLFASNIG | SNHYVGLAGT | GAASGVATVT | ||||
| FEWTSSVMLL | ILGWIFVPIY | IKSGVMTMPE | YLKKRFGGER | LQVYLSILSL | ||||
| FICVVLLISA | DIFAGAIFIK | LALGLDLYLA | IFILLAMTAV | YTTTGGLASV | ||||
| IYTDTLQTII | MLIGSFILMG | FAFNEVGGYE | SFTEKYVNAT | PSVVEGDNLT | ||||
| ISASCYTPRA | DSFHIFRDAV | TGDIPWPGII | FGMPITALWY | WCTNQVIVQR | ||||
| CLCGKDMSHV | KAACIMCAYL | KLLPMFLMVM | PGMISRILYT | DMVACVVPSE | ||||
| CVKHCGVDVG | CTNYAYPTMV | LELMPQGLRG | LMLSVMLASL | MSSLTSIFNS | ||||
| ASTLFTIDLY | TKMRKQASEK | ELLIAGRIFV | LLLTVVSIVW | VPLVQVSQNG | ||||
| QLIHYTESIS | SYLGPPIAAV | FVLAIFCKRV | NEQGAFWGLM | VGLAMGLIRM | ||||
| ITEFAYGTGS | CLAPSNCPKI | ICGVHYLYFS | IVLFFGSMLV | TLGISLLTKP | ||||
| IPDVHLYRLC | WVLRNSTEER | IDIDAEEKSQ | EETDDGVEED | YPEKSRGCLK | ||||
| KAYDLFCGLQ | KGPKLTKEEE | EALSKKLTDT | SERPSWRTIV | NINAILLLAV | ||||
| VVFIHGYYA |
Reference
uredi- ^ a b c GRCh38: Ensembl release 89: ENSG00000180251 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026065 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: solute carrier family 5 (low affinity glucose cotransporter)".
- ^ Veyhl M, Wagner K, Volk C, Gorboulev V, Baumgarten K, Weber WM, Schaper M, Bertram B, Wiessler M, Koepsell H (mart 1998). "Transport of the new chemotherapeutic agent beta-D-glucosylisophosphoramide mustard (D-19575) into tumor cells is mediated by the Na+-D-glucose cotransporter SAAT1". Proceedings of the National Academy of Sciences of the United States of America. 95 (6): 2914–9. Bibcode:1998PNAS...95.2914V. doi:10.1073/pnas.95.6.2914. PMC 19669. PMID 9501190.
- ^ Jung H (oktobar 2002). "The sodium/substrate symporter family: structural and functional features". FEBS Letters. 529 (1): 73–7. doi:10.1016/S0014-5793(02)03184-8. PMID 12354616.
- ^ "UniProt, Q9NY91" (jezik: engleski). Pristupljeno 19. 11. 2021.
Dpunska literatura
uredi- Munafò MR, Clark TG, Roberts KH, Johnstone EC (2006). "Neuroticism mediates the association of the serotonin transporter gene with lifetime major depression". Neuropsychobiology. 53 (1): 1–8. doi:10.1159/000089915. PMID 16319503. S2CID 12803994.
- Blaya C, Salum GA, Lima MS, Leistner-Segal S, Manfro GG (2007). "Lack of association between the Serotonin Transporter Promoter Polymorphism (5-HTTLPR) and Panic Disorder: a systematic review and meta-analysis". Behavioral and Brain Functions. 3: 41. doi:10.1186/1744-9081-3-41. PMC 1994953. PMID 17705872.
- Diez-Sampedro A, Hirayama BA, Osswald C, Gorboulev V, Baumgarten K, Volk C, Wright EM, Koepsell H (septembar 2003). "A glucose sensor hiding in a family of transporters". Proceedings of the National Academy of Sciences of the United States of America. 100 (20): 11753–8. Bibcode:2003PNAS..10011753D. doi:10.1073/pnas.1733027100. PMC 208830. PMID 13130073.
- Fairchild TJ (januar 2008). "Protection of muscle membrane excitability during cycling in humans: a role for SGLT3?". Journal of Applied Physiology. 104 (1): 315, author reply 316. doi:10.1152/japplphysiol.00793.2007. PMID 18198291.
- Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (decembar 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
- Voss AA, Díez-Sampedro A, Hirayama BA, Loo DD, Wright EM (februar 2007). "Imino sugars are potent agonists of the human glucose sensor SGLT3". Molecular Pharmacology. 71 (2): 628–34. doi:10.1124/mol.106.030288. PMID 17110502. S2CID 13642065.