SLC8B1

SLC8B1
Identifikatori
Aliasi	SLC8B1
Vanjski ID-jevi	OMIM: 609841 MGI: 2180781 HomoloGene: 41602 GeneCards: SLC8B1
Lokacija gena (čovjek)
Hrom.	Hromosom 12 (čovjek)
Kraj	113,359,493 bp
Lokacija gena (miš)
Hrom.	Hromosom 5 (miš)
Kraj	120,672,089 bp
Ontologija gena
Molekularna funkcija	• protein homodimerization activity; • vezivanje identičnih proteina; • antiporter activity; • calcium:cation antiporter activity; • calcium:sodium antiporter activity; • calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential;
Ćelijska komponenta	• integral component of membrane; • membrana; • ćelijska membrana; • Krista; • mitohondrija; • integral component of mitochondrial membrane; • Sarkolema; • mitochondrial inner membrane;
Biološki proces	• sodium ion transmembrane transport; • regulation of cytosolic calcium ion concentration; • glucose homeostasis; • response to stimulus; • regulation of insulin secretion; • sodium ion transport; • ion transport; • calcium ion transmembrane transport; • regulation of cardiac muscle cell membrane potential; • calcium ion transport; • transmembrane transport; • mitochondrial calcium ion transmembrane transport; • mitochondrial calcium ion homeostasis; • calcium export from the mitochondrion; • regulation of lymphocyte chemotaxis; • regulation of store-operated calcium entry;
	Izvori:Amigo / QuickGO
Ortolozi
	80024
	170756
	ENSG00000089060
	ENSMUSG00000032754
	Q6J4K2
	Q925Q3
	NM_024959; NM_001330466; NM_001358345
	NM_001177594; NM_001177595; NM_133221
	NP_001317395; NP_079235; NP_001345274
	NP_001171065; NP_001171066; NP_573484
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Član B1 porodice rastvornih nosača 8 (natrij/litij/kalcijski izmjenjivač exchanger) je protein koji je kod ljudi kodiran genom SLC8B1.^[5]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 584 aminokiselina, a molekulska težina 64.231 Da.^[6]

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin

I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

10	20	30	40	50
MAGRRLNLRW	ALSVLCVLLM	AETVSGTRGS	STGAHISPQF	PASGVNQTPV
VDCRKVCGLN	VSDRCDFIRT	NPDCHSDGGY	LDYLEGIFCH	FPPSLLPLAV
TLYVSWLLYL	FLILGVTAAK	FFCPNLSAIS	TTLKLSHNVA	GVTFLAFGNG
APDIFSALVA	FSDPHTAGLA	LGALFGAGVL	VTTVVAGGIT	ILHPFMAASR
PFFRDIVFYM	VAVFLTFLML	FRGRVTLAWA	LGYLGLYVFY	VVTVILCTWI
YQRQRRGSLF	CPMPVTPEIL	SDSEEDRVSS	NTNSYDYGDE	YRPLFFYQET
TAQILVRALN	PLDYMKWRRK	SAYWKALKVF	KLPVEFLLLL	TVPVVDPDKD
DQNWKRPLNC	LHLVISPLVV	VLTLQSGTYG	VYEIGGLVPV	WVVVVIAGTA
LASVTFFATS	DSQPPRLHWL	FAFLGFLTSA	LWINAAATEV	VNILRSLGVV
FRLSNTVLGL	TLLAWGNSIG	DAFSDFTLAR	QGYPRMAFSA	CFGGIIFNIL
VGVGLGCLLQ	ISRSHTEVKL	EPDGLLVWVL	AGALGLSLVF	SLVSVPLQCF
QLSRVYGFCL	LLFYLNFLVV	ALLTEFGVIH	LKSM

Funkcija

SLC24A6 pripada porodici Kalij-ovisni izmjenjivač natrij-kalcij koji održavaju ćelijsku homeostazu kalcija, putem elektrogenog protivtransporta četiri iona natrija za jedan ion kalcija i jedan kalija.^[7]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000089060 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032754 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Solute carrier family 8 (sodium/lithium/calcium exchanger), member B1".
^ "UniProt, Q6J4K2". Pristupljeno 14. 8. 2021.
^ Cai X, Lytton J (februar 2004). "Molecular cloning of a sixth member of the K+-dependent Na+/Ca2+ exchanger gene family, NCKX6". The Journal of Biological Chemistry. 279 (7): 5867–76. doi:10.1074/jbc.M310908200. PMID 14625281.

Dopunska literatura

Boyman L, Williams GS, Khananshvili D, Sekler I, Lederer WJ (juni 2013). "NCLX: the mitochondrial sodium calcium exchanger". Journal of Molecular and Cellular Cardiology. 59: 205–13. doi:10.1016/j.yjmcc.2013.03.012. PMC 3951392. PMID 23538132.
Palty R, Ohana E, Hershfinkel M, Volokita M, Elgazar V, Beharier O, Silverman WF, Argaman M, Sekler I (juni 2004). "Lithium-calcium exchange is mediated by a distinct potassium-independent sodium-calcium exchanger". The Journal of Biological Chemistry. 279 (24): 25234–40. doi:10.1074/jbc.M401229200. PMID 15060069.
Aslibekyan S, An P, Frazier-Wood AC, Kabagambe EK, Irvin MR, Straka RJ, Tiwari HK, Tsai MY, Hopkins PN, Borecki IB, Ordovas JM, Arnett DK (oktobar 2013). "Preliminary evidence of genetic determinants of adiponectin response to fenofibrate in the Genetics of Lipid Lowering Drugs and Diet Network". Nutrition, Metabolism, and Cardiovascular Diseases. 23 (10): 987–94. doi:10.1016/j.numecd.2012.07.010. PMC 3578131. PMID 23149075.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000089060 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032754 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Solute carrier family 8 (sodium/lithium/calcium exchanger), member B1".

[UniProt-6] "UniProt, Q6J4K2". Pristupljeno 14. 8. 2021.

[pmid14625281-7] Cai X, Lytton J (februar 2004). "Molecular cloning of a sixth member of the K+-dependent Na+/Ca2+ exchanger gene family, NCKX6". The Journal of Biological Chemistry. 279 (7): 5867–76. doi:10.1074/jbc.M310908200. PMID 14625281.

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