SIT1

SIT1
Identifikatori
Aliasi	SIT1
Vanjski ID-jevi	OMIM: 604964 MGI: 1889342 HomoloGene: 8694 GeneCards: SIT1
Lokacija gena (čovjek)
Hrom.	Hromosom 9 (čovjek)
Kraj	35,650,931 bp
Lokacija gena (miš)
Hrom.	Hromosom 4 (miš)
Kraj	43,483,734 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine; • SH2 domain binding; • kinase binding;
Ćelijska komponenta	• integral component of membrane; • integral component of plasma membrane; • ćelijska membrana; • Egzosom; • membrana;
Biološki proces	• adaptive immune response; • immune system process; • T cell homeostasis; • regulation of T cell activation; • GO:0072468 Transdukcija signala;
	Izvori:Amigo / QuickGO
Ortolozi
	27240
	54390
	ENSG00000137078
	ENSMUSG00000028460
	Q9Y3P8
	Q8C503
	NM_014450
	NM_019436
	NP_055265
	NP_062309
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Transmembranski adapter 1 pražne regulacije je protein koji je kod ljudi kodiran genom SIT1.^[5]^[6]^[7]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 196 aminokiselina, а molekulska težina Da. 21 126^[8]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MNQADPRLRA	VCLWTLTSAA	MSRGDNCTDL	LALGIPSITQ	AWGLWVLLGA
VTLLFLISLA	AHLSQWTRGR	SRSHPGQGRS	GESVEEVPLY	GNLHYLQTGR
LSQDPEPDQQ	DPTLGGPARA	AEEVMCYTSL	QLRPPQGRIP	GPGTPVKYSE
VVLDSEPKSQ	ASGPEPELYA	SVCAQTRRAR	ASFPDQAYAN	SQPAAS

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000137078 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028460 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hubener C, Mincheva A, Lichter P, Schraven B, Bruyns E (Aug 2001). "Complete sequence, genomic organization, and chromosomal localization of the human gene encoding the SHP2-interacting transmembrane adaptor protein (SIT)". Immunogenetics. 53 (4): 337–41. doi:10.1007/s002510100328. PMID 11491537. S2CID 34405743.
^ Marie-Cardine A, Kirchgessner H, Bruyns E, Shevchenko A, Mann M, Autschbach F, Ratnofsky S, Meuer S, Schraven B (maj 1999). "SHP2-interacting Transmembrane Adaptor Protein (SIT), A Novel Disulfide-linked Dimer Regulating Human T Cell Activation". J Exp Med. 189 (8): 1181–94. doi:10.1084/jem.189.8.1181. PMC 2193021. PMID 10209036.
^ "Entrez Gene: SIT1 signaling threshold regulating transmembrane adaptor 1".
^ "UniProt, Q9Y3P8". Pristupljeno 11. 9. 2021.

Dopunska literatura

Adams MD, Kerlavage AR, Fleischmann RD, et al. (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF). Nature. 377 (6547 Suppl): 3–174. PMID 7566098.
Pfrepper KI, Marie-Cardine A, Simeoni L, et al. (2001). "Structural and functional dissection of the cytoplasmic domain of the transmembrane adaptor protein SIT (SHP2-interacting transmembrane adaptor protein)". Eur. J. Immunol. 31 (6): 1825–36. doi:10.1002/1521-4141(200106)31:6<1825::AID-IMMU1825>3.0.CO;2-V. PMID 11433379.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ficarro SB, Salomon AR, Brill LM, et al. (2005). "Automated immobilized metal affinity chromatography/nano-liquid chromatography/electrospray ionization mass spectrometry platform for profiling protein phosphorylation sites". Rapid Commun. Mass Spectrom. 19 (1): 57–71. Bibcode:2005RCMS...19...57F. doi:10.1002/rcm.1746. PMID 15570572.
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
Tao WA, Wollscheid B, O'Brien R, et al. (2005). "Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry". Nat. Methods. 2 (8): 591–8. doi:10.1038/nmeth776. PMID 16094384. S2CID 20475874.
Tedoldi S, Paterson JC, Hansmann ML, et al. (2006). "Transmembrane adaptor molecules: a new category of lymphoid-cell markers". Blood. 107 (1): 213–21. doi:10.1182/blood-2005-06-2273. PMID 16160011.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000137078 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028460 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11491537-5] Hubener C, Mincheva A, Lichter P, Schraven B, Bruyns E (Aug 2001). "Complete sequence, genomic organization, and chromosomal localization of the human gene encoding the SHP2-interacting transmembrane adaptor protein (SIT)". Immunogenetics. 53 (4): 337–41. doi:10.1007/s002510100328. PMID 11491537. S2CID 34405743.

[pmid10209036-6] Marie-Cardine A, Kirchgessner H, Bruyns E, Shevchenko A, Mann M, Autschbach F, Ratnofsky S, Meuer S, Schraven B (maj 1999). "SHP2-interacting Transmembrane Adaptor Protein (SIT), A Novel Disulfide-linked Dimer Regulating Human T Cell Activation". J Exp Med. 189 (8): 1181–94. doi:10.1084/jem.189.8.1181. PMC 2193021. PMID 10209036.

[entrez-7] "Entrez Gene: SIT1 signaling threshold regulating transmembrane adaptor 1".

[UniProt-8] "UniProt, Q9Y3P8". Pristupljeno 11. 9. 2021.

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