SH3YL1

Protein 1 sa SH3 i SYLF domenom jest protein koji je kod ljudi kodiran genom SH3YL1 sa hromosoma 2.

SH3YL1
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 2D8H
Identifikatori
Aliasi	SH3YL1
Vanjski ID-jevi	OMIM: 617314 MGI: 1346118 HomoloGene: 31662 GeneCards: SH3YL1
Lokacija gena (čovjek) Hrom. Hromosom 2 (čovjek) Bend 2p25.3 Početak 217,730 bp Kraj 266,398 bp
Lokacija gena (miš) Hrom. Hromosom 12 (miš) Bend 12|12 A2 Početak 30,961,667 bp Kraj 31,010,161 bp
Ontologija gena Molekularna funkcija • phosphatase binding • GO:0001948, GO:0016582 vezivanje za proteine • phosphatidylinositol binding Ćelijska komponenta • ruffle membrane Biološki proces • phosphatidylinositol biosynthetic process • regulation of ruffle assembly Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	26751	24057
Ensembl	ENSG00000035115	ENSMUSG00000020669
UniProt	Q96HL8	O08641
RefSeq (mRNK)	NM_001159597 NM_001282682 NM_001282687 NM_015677	NM_001289480 NM_013709
RefSeq (bjelančevina)	NP_001153069 NP_001269611 NP_001269616 NP_056492	NP_001276409 NP_038737
Lokacija (UCSC)	Chr 2: 0.22 – 0.27 Mb	Chr 12: 30.96 – 31.01 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Amiokiselininska sekvenca

Dužina polipeptidnog lanca je 342 aminokiseline, a molekulska težina 37.148 Da.

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MNNPIPSNLK		SEAKKAAKIL		REFTEITSRN		GPDKIIPAHV		IAKAKGLAIL
SVIKAGFLVT		ARGGSGIVVA		RLPDGKWSAP		SAIGIAGLGG		GFEIGIEVSD
LVIILNYDRA		VEAFAKGGNL		TLGGNLTVAV		GPLGRNLEGN		VALRSSAAVF
TYCKSRGLFA		GVSLEGSCLI		ERKETNRKFY		CQDIRAYDIL		FGDTPRPAQA
EDLYEILDSF		TEKYENEGQR		INARKAAREQ		RKSSAKELPP		KPLSRPQQSS
APVQLNSGSQ		SNRNEYKLYP		GLSSYHERVG		NLNQPIEVTA		LYSFEGQQPG
DLNFQAGDRI		TVISKTDSHF		DWWEGKLRGQ		TGIFPANYVT		MN

Dopunska literatura

• Asbach B, Ludwig C, Saksela K, Wagner R (2012). "Comprehensive analysis of interactions between the Src-associated protein in mitosis of 68 kDa and the human Src-homology 3 proteome". PLOS ONE. 7 (6): e38540. Bibcode:2012PLoSO...738540A. doi:10.1371/journal.pone.0038540. PMC 3379994. PMID 22745667.
• Hasegawa J, Tokuda E, Tenno T, Tsujita K, Sawai H, Hiroaki H, Takenawa T, Itoh T (maj 2011). "SH3YL1 regulates dorsal ruffle formation by a novel phosphoinositide-binding domain". The Journal of Cell Biology. 193 (5): 901–16. doi:10.1083/jcb.201012161. PMC 3105542. PMID 21624956.
• Aoki N, Ito K, Ito M (maj 2000). "A novel mouse gene, Sh3yl1, is expressed in the anagen hair follicle". The Journal of Investigative Dermatology. 114 (5): 1050–6. doi:10.1046/j.1523-1747.2000.00971.x. PMID 10771491.
• Shimomura Y, Aoki N, Ito K, Ito M (februar 2003). "Gene expression of Sh3d19, a novel adaptor protein with five Src homology 3 domains, in anagen mouse hair follicles". Journal of Dermatological Science. 31 (1): 43–51. doi:10.1016/s0923-1811(02)00140-8. PMID 12615363.