SESN3

Sestrin 3 je protein koji je kod ljudi kodiran genom SESN3.

SESN3
Identifikatori
Aliasi	SESN3
Vanjski ID-jevi	OMIM: 607768 MGI: 1922997 HomoloGene: 14386 GeneCards: SESN3
Lokacija gena (čovjek) Hrom. Hromosom 11 (čovjek) Bend 11q21 Početak 95,165,513 bp Kraj 95,232,541 bp
Lokacija gena (miš) Hrom. Hromosom 9 (miš) Bend 9|9 A1 Početak 14,186,363 bp Kraj 14,244,397 bp
Ontologija gena Molekularna funkcija • oxidoreductase activity • GO:0001948, GO:0016582 vezivanje za proteine • oxidoreductase activity, acting on peroxide as acceptor • leucine binding Ćelijska komponenta • jedro • citoplazma • GATOR2 complex • TORC2 complex Biološki proces • regulation of response to reactive oxygen species • negative regulation of TORC1 signaling • response to insulin • glucose homeostasis • regulation of protein kinase B signaling • TORC2 signaling • GO:1903104 regulation of insulin receptor signaling pathway • cellular response to amino acid starvation • cellular response to glucose starvation • cellular response to amino acid stimulus • positive regulation of macroautophagy • cellular response to leucine • cellular response to leucine starvation Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	143686	75747
Ensembl	ENSG00000149212	ENSMUSG00000032009
UniProt	P58005	Q9CYP7
RefSeq (mRNK)	NM_001271594 NM_144665	NM_030261
RefSeq (bjelančevina)	NP_001258523 NP_653266	NP_084537
Lokacija (UCSC)	Chr 11: 95.17 – 95.23 Mb	Chr 9: 14.19 – 14.24 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 492 aminokiseline, а molekulska težina 57.291 Da..

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MNRGGGSPSA		AANYLLCTNC		RKVLRKDKRI		RVSQPLTRGP		SAFIPEKEVV
QANTVDERTN		FLVEEYSTSG		RLDNITQVMS		LHTQYLESFL		RSQFYMLRMD
GPLPLPYRHY		IAIMAAARHQ		CSYLINMHVD		EFLKTGGIAE		WLNGLEYVPQ
RLKNLNEINK		LLAHRPWLIT		KEHIQKLVKT		GENNWSLPEL		VHAVVLLAHY
HALASFVFGS		GINPERDPEI		SNGFRLISVN		NFCVCDLAND		NNIENASLSG
SNFGIVDSLS		ELEALMERMK		RLQEEREDEE		ASQEEMSTRF		EKEKKESLFV
VSGDTFHSFP		HSDFEDDMII		TSDVSRYIED		PGFGYEDFAR		RGEEHLPTFR
AQDYTWENHG		FSLVNRLYSD		IGHLLDEKFR		MVYNLTYNTM		ATHEDVDTTM
LRRALFNYVH		CMFGIRYDDY		DYGEVNQLLE		RSLKVYIKTV		TCYPERTTKR
MYDSYWRQFK		HSEKVHVNLL		LMEARMQAEL		LYALRAITRH		LT

Funkcija

Ovaj gen kodira člana porodice sestrinskih proteina izazvanih stresom. Kodirani protein smanjuje razine unutarćelijsnkih reaktivnih vrsta kisika induciranih aktiviranim Ras-om nizvodno od RAC-alfa serin/treonin-protein kinaze (Akt) i transkripcijskog faktora FoxO. Proteini su potrebni za normalnu regulaciju glukoze u krvi, otpornost na insulin i imaju ulogu u skladištenju lipida u gojaznosti. Alternativna prerada rezultira u više varijanti transkripta.

Dopumska literatura

• Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
• Chen CC, Jeon SM, Bhaskar PT, Nogueira V, Sundararajan D, Tonic I, Park Y, Hay N (2010). "FoxOs inhibit mTORC1 and activate Akt by inducing the expression of Sestrin3 and Rictor". Dev. Cell. 18 (4): 592–604. doi:10.1016/j.devcel.2010.03.008. PMC 3031984. PMID 20412774.
• Zamkova M, Khromova N, Kopnin BP, Kopnin P (2013). "Ras-induced ROS upregulation affecting cell proliferation is connected with cell type-specific alterations of HSF1/SESN3/p21Cip1/WAF1 pathways". Cell Cycle. 12 (5): 826–36. doi:10.4161/cc.23723. PMC 3610730. PMID 23388456.
• Nascimento EB, Osler ME, Zierath JR (2013). "Sestrin 3 regulation in type 2 diabetic patients and its influence on metabolism and differentiation in skeletal muscle". Am. J. Physiol. Endocrinol. Metab. 305 (11): E1408–14. doi:10.1152/ajpendo.00212.2013. PMC 3882372. PMID 24129397.
• Vakana E, Arslan AD, Szilard A, Altman JK, Platanias LC (2013). "Regulatory effects of sestrin 3 (SESN3) in BCR-ABL expressing cells". PLOS ONE. 8 (11): e78780. Bibcode:2013PLoSO...878780V. doi:10.1371/journal.pone.0078780. PMC 3832611. PMID 24260131.
• Kang X, Petyaykina K, Tao R, Xiong X, Dong XC, Liangpunsakul S (2014). "The inhibitory effect of ethanol on Sestrin3 in the pathogenesis of ethanol-induced liver injury". Am. J. Physiol. Gastrointest. Liver Physiol. 307 (1): G58–65. doi:10.1152/ajpgi.00373.2013. PMC 4080163. PMID 24833709.