SERINC1

SERINC1
Identifikatori
Aliasi	SERINC1
Vanjski ID-jevi	OMIM: 614548 MGI: 1926228 HomoloGene: 41334 GeneCards: SERINC1
Lokacija gena (čovjek)
Hrom.	Hromosom 6 (čovjek)
Kraj	122,471,807 bp
Lokacija gena (miš)
Hrom.	Hromosom 10 (miš)
Kraj	57,408,626 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine; • vezivanje enzima; • protein-macromolecule adaptor activity; • L-serine transmembrane transporter activity;
Ćelijska komponenta	• ćelijska membrana; • endoplasmic reticulum membrane; • Endoplazmatski retikulum; • membrana; • integral component of membrane;
Biološki proces	• phosphatidylserine metabolic process; • positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity; • positive regulation of serine C-palmitoyltransferase activity; • sphingolipid metabolic process; • phospholipid biosynthetic process; • lipid metabolism; • L-serine transport; • membrane biogenesis;
	Izvori:Amigo / QuickGO
Ortolozi
	57515
	56442
	ENSG00000111897
	ENSMUSG00000019877
	Q9NRX5
	Q9QZI8
	NM_020755
	NM_019760
	NP_065806
	NP_062734
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Serinski inkorporator 1 jest protein koji je kod ljudi kodiran genom SERINC1.^[5]^[6]

Aminokiselinska sekvenca uredi

Dužina polipeptidnog lanca je 453 aminokiseline, а molekulska težina 50.495 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MGSVLGLCSM	ASWIPCLCGS	APCLLCRCCP	SGNNSTVTRL	IYALFLLVGV
CVACVMLIPG	MEEQLNKIPG	FCENEKGVVP	CNILVGYKAV	YRLCFGLAMF
YLLLSLLMIK	VKSSSDPRAA	VHNGFWFFKF	AAAIAIIIGA	FFIPEGTFTT
VWFYVGMAGA	FCFILIQLVL	LIDFAHSWNE	SWVEKMEEGN	SRCWYAALLS
ATALNYLLSL	VAIVLFFVYY	THPASCSENK	AFISVNMLLC	VGASVMSILP
KIQESQPRSG	LLQSSVITVY	TMYLTWSAMT	NEPETNCNPS	LLSIIGYNTT
STVPKEGQSV	QWWHAQGIIG	LILFLLCVFY	SSIRTSNNSQ	VNKLTLTSDE
STLIEDGGAR	SDGSLEDGDD	VHRAVDNERD	GVTYSYSFFH	FMLFLASLYI
MMTLTNWYRY	EPSREMKSQW	TAVWVKISSS	WIGIVLYVWT	LVAPLVLTNR
DFD

Reference uredi

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000111897 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000019877 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Grossman TR, Luque JM, Nelson N (Apr 2000). "Identification of a ubiquitous family of membrane proteins and their expression in mouse brain". J Exp Biol. 203 (Pt 3): 447–57. doi:10.1242/jeb.203.3.447. PMID 10637174.
^ "Entrez Gene: SERINC1 serine incorporator 1".
^ "UniProt, Q9NRX5" (jezik: engleski). Pristupljeno 10. 10. 2021.

Dopunska literatura uredi

Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. Bibcode:2000PNAS...97.9543H. doi:10.1073/pnas.160270997. PMC 16901. PMID 10931946.
Nagase T, Ishikawa K, Kikuno R, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (5): 337–45. doi:10.1093/dnares/6.5.337. PMID 10574462.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000111897 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000019877 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10637174-5] Grossman TR, Luque JM, Nelson N (Apr 2000). "Identification of a ubiquitous family of membrane proteins and their expression in mouse brain". J Exp Biol. 203 (Pt 3): 447–57. doi:10.1242/jeb.203.3.447. PMID 10637174.

[entrez-6] "Entrez Gene: SERINC1 serine incorporator 1".

[UniProt-7] "UniProt, Q9NRX5" (jezik: engleski). Pristupljeno 10. 10. 2021.

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