SCRN1

SCRN1
Identifikatori
Aliasi	SCRN1
Vanjski ID-jevi	OMIM: 614965 MGI: 1917188 HomoloGene: 8853 GeneCards: SCRN1
Lokacija gena (čovjek)
Hrom.	Hromosom 7 (čovjek)
Kraj	29,990,289 bp
Lokacija gena (miš)
Hrom.	Hromosom 6 (miš)
Kraj	54,543,474 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine; • dipeptidase activity; • molekularna funkcija;
Ćelijska komponenta	• citoplazma; • Jedarna membrana; • jedro;
Biološki proces	• Proteoliza; • Egzocitoza;
	Izvori:Amigo / QuickGO
Ortolozi
	9805
	69938
	ENSG00000136193
	ENSMUSG00000019124
	Q12765
	Q9CZC8
	NM_001145513; NM_001145514; NM_001145515; NM_014766
	NM_027268
	NP_001138985; NP_001138986; NP_001138987; NP_055581
	NP_081544
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Sekernin-1 je protein koji je kod ljudi kodiran genom SCRN1.^[5]^[6]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 414 aminokiselina, а molekulska težina 46.382 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MAAAPPSYCF	VAFPPRAKDG	LVVFGKNSAR	PRDEVQEVVY	FSAADHEPES
KVECTYISID	QVPRTYAIMI	SRPAWLWGAE	MGANEHGVCI	ANEAINTREP
AAEIEALLGM	DLVRLGLERG	ETAKEALDVI	VSLLEEHGQG	GNYFEDANSC
HSFQSAYLIV	DRDEAWVLET	IGKYWAAEKV	TEGVRCICSQ	LSLTTKMDAE
HPELRSYAQS	QGWWTGEGEF	NFSEVFSPVE	DHLDCGAGKD	SLEKQEESIT
VQTMMNTLRD	KASGVCIDSE	FFLTTASGVS	VLPQNRSSPC	IHYFTGTPDP
SRSIFKPFIF	VDDVKLVPKT	QSPCFGDDDP	AKKEPRFQEK	PDRRHELYKA
HEWARAIIES	DQEQGRKLRS	TMLELEKQGL	EAMEEILTSS	EPLDPAEVGD
LFYDCVDTEI	KFFK

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000136193 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000019124 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Way G, Morrice N, Smythe C, O'Sullivan AJ (Sep 2002). "Purification and identification of secernin, a novel cytosolic protein that regulates exocytosis in mast cells" (PDF). Mol Biol Cell. 13 (9): 3344–54. doi:10.1091/mbc.E01-10-0094. PMC 124164. PMID 12221138.
^ "Entrez Gene: SCRN1 secernin 1".
^ "UniProt, Q12765" (jezik: engleski). Pristupljeno 27. 9. 2021.

Dopunska literatura

Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
Nagase T, Seki N, Ishikawa K, et al. (1996). "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 3 (1): 17–24. doi:10.1093/dnares/3.1.17. PMID 8724849.
Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
Hoja MR, Wahlestedt C, Höög C (2000). "A visual intracellular classification strategy for uncharacterized human proteins". Exp. Cell Res. 259 (1): 239–46. doi:10.1006/excr.2000.4948. PMID 10942595.
O'Neill EE, Brock CJ, von Kriegsheim AF, et al. (2002). "Towards complete analysis of the platelet proteome". Proteomics. 2 (3): 288–305. doi:10.1002/1615-9861(200203)2:3<288::AID-PROT288>3.0.CO;2-0. PMID 11921445.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Suda T, Tsunoda T, Uchida N, et al. (2006). "Identification of secernin 1 as a novel immunotherapy target for gastric cancer using the expression profiles of cDNA microarray". Cancer Sci. 97 (5): 411–9. doi:10.1111/j.1349-7006.2006.00194.x. PMID 16630140. S2CID 25739515.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000136193 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000019124 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12221138-5] Way G, Morrice N, Smythe C, O'Sullivan AJ (Sep 2002). "Purification and identification of secernin, a novel cytosolic protein that regulates exocytosis in mast cells" (PDF). Mol Biol Cell. 13 (9): 3344–54. doi:10.1091/mbc.E01-10-0094. PMC 124164. PMID 12221138.

[entrez-6] "Entrez Gene: SCRN1 secernin 1".

[UniProt-7] "UniProt, Q12765" (jezik: engleski). Pristupljeno 27. 9. 2021.

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