Protein 1 sa SAM i SH3 domenom jest protein koji je kod ljudi kodiran genom SASH1.[5][6][7]

SASH1
Dostupne strukture
PDBPretraga ortologa: PDBe RCSB
Spisak PDB ID kodova

2EBP

Identifikatori
AliasiSASH1
Vanjski ID-jeviOMIM: 607955 MGI: 1917347 HomoloGene: 69182 GeneCards: SASH1
Lokacija gena (čovjek)
Hromosom 6 (čovjek)
Hrom.Hromosom 6 (čovjek)[1]
Hromosom 6 (čovjek)
Genomska lokacija za SASH1
Genomska lokacija za SASH1
Bend6q24.3-q25.1Početak148,272,304 bp[1]
Kraj148,552,044 bp[1]
Lokacija gena (miš)
Hromosom 10 (miš)
Hrom.Hromosom 10 (miš)[2]
Hromosom 10 (miš)
Genomska lokacija za SASH1
Genomska lokacija za SASH1
Bend10|10 A1Početak8,597,983 bp[2]
Kraj8,761,814 bp[2]
Obrazac RNK ekspresije


Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija mitogen-activated protein kinase kinase kinase binding
GO:0032947 molecular adaptor activity
protein C-terminus binding
protein kinase binding
Ćelijska komponenta GO:0009327 makromolekulani kompleks
Biološki proces positive regulation of endothelial cell migration
positive regulation of lipopolysaccharide-mediated signaling pathway
positive regulation of JUN kinase activity
regulation of protein K63-linked ubiquitination
positive regulation of p38MAPK cascade
regulation of protein autoubiquitination
protein polyubiquitination
positive regulation of NIK/NF-kappaB signaling
positive regulation of angiogenesis
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)
NM_015278
NM_001346505
NM_001346506
NM_001346507
NM_001346508

NM_001346509

NM_175155

RefSeq (bjelančevina)
NP_001333434
NP_001333435
NP_001333436
NP_001333437
NP_001333438

NP_056093

NP_780364

Lokacija (UCSC)Chr 6: 148.27 – 148.55 MbChr 10: 8.6 – 8.76 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Aminokiselinska sekvenca

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Dužina polipeptidnog lanca je 1.247 aminokiselina, а molekulska težina 136.653 Da.[8]

1020304050
MEDAGAAGPGPEPEPEPEPEPEPAPEPEPEPKPGAGTSEAFSRLWTDVMG
ILDGSLGNIDDLAQQYADYYNTCFSDVCERMEELRKRRVSQDLEVEKPDA
SPTSLQLRSQIEESLGFCSAVSTPEVERKNPLHKSNSEDSSVGKGDWKKK
NKYFWQNFRKNQKGIMRQTSKGEDVGYVASEITMSDEERIQLMMMVKEKM
ITIEEALARLKEYEAQHRQSAALDPADWPDGSYPTFDGSSNCNSREQSDD
ETEESVKFKRLHKLVNSTRRVRKKLIRVEEMKKPSTEGGEEHVFENSPVL
DERSALYSGVHKKPLFFDGSPEKPPEDDSDSLTTSPSSSSLDTWGAGRKL
VKTFSKGESRGLIKPPKKMGTFFSYPEEEKAQKVSRSLTEGEMKKGLGSL
SHGRTCSFGGFDLTNRSLHVGSNNSDPMGKEGDFVYKEVIKSPTASRISL
GKKVKSVKETMRKRMSKKYSSSVSEQDSGLDGMPGSPPPSQPDPEHLDKP
KLKAGGSVESLRSSLSGQSSMSGQTVSTTDSSTSNRESVKSEDGDDEEPP
YRGPFCGRARVHTDFTPSPYDTDSLKLKKGDIIDIISKPPMGTWMGLLNN
KVGTFKFIYVDVLSEDEEKPKRPTRRRRKGRPPQPKSVEDLLDRINLKEH
MPTFLFNGYEDLDTFKLLEEEDLDELNIRDPEHRAVLLTAVELLQEYDSN
SDQSGSQEKLLVDSQGLSGCSPRDSGCYESSENLENGKTRKASLLSAKSS
TEPSLKSFSRNQLGNYPTLPLMKSGDALKQGQEEGRLGGGLAPDTSKSCD
PPGVTGLNKNRRSLPVSICRSCETLEGPQTVDTWPRSHSLDDLQVEPGAE
QDVPTEVTEPPPQIVPEVPQKTTASSTKAQPLEQDSAVDNALLLTQSKRF
SEPQKLTTKKLEGSIAASGRGLSPPQCLPRNYDAQPPGAKHGLARTPLEG
HRKGHEFEGTHHPLGTKEGVDAEQRMQPKIPSQPPPVPAKKSRERLANGL
HPVPMGPSGALPSPDAPCLPVKRGSPASPTSPSDCPPALAPRPLSGQAPG
SPPSTRPPPWLSELPENTSLQEHGVKLGPALTRKVSCARGVDLETLTENK
LHAEGIDLTEEPYSDKHGRCGIPEALVQRYAEDLDQPERDVAANMDQIRV
KQLRKQHRMAIPSGGLTEICRKPVSPGCISSVSDWLISIGLPMYAGTLST
AGFSTLSQVPSLSHTCLQEAGITEERHIRKLLSAARLFKLPPGPEAM

Reference

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000111961 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000015305 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Apr 1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
  6. ^ Zeller C, Hinzmann B, Seitz S, Prokoph H, Burkhard-Goettges E, Fischer J, Jandrig B, Schwarz LE, Rosenthal A, Scherneck S (maj 2003). "SASH1: a candidate tumor suppressor gene on chromosome 6q24.3 is downregulated in breast cancer". Oncogene. 22 (19): 2972–83. doi:10.1038/sj.onc.1206474. PMID 12771949.
  7. ^ "Entrez Gene: SASH1 SAM and SH3 domain containing 1".
  8. ^ "UniProt, O94885" (jezik: engleski). Pristupljeno 10. 10. 2021.

Dopunska literatura

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Vanjski linkovi

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