Homolog regulacijskog proteina ribosomske biogeneze je protein koji je kod ljudi kodiran genom RRS1.[5][6][7]

RRS1
Identifikatori
AliasiRRS1
Vanjski ID-jeviOMIM: 618311 MGI: 1929721 HomoloGene: 41014 GeneCards: RRS1
Lokacija gena (čovjek)
Hromosom 8 (čovjek)
Hrom.Hromosom 8 (čovjek)[1]
Hromosom 8 (čovjek)
Genomska lokacija za RRS1
Genomska lokacija za RRS1
Bend8q13.1Početak66,429,014 bp[1]
Kraj66,430,733 bp[1]
Lokacija gena (miš)
Hromosom 1 (miš)
Hrom.Hromosom 1 (miš)[2]
Hromosom 1 (miš)
Genomska lokacija za RRS1
Genomska lokacija za RRS1
Bend1 A2|1 2.08 cMPočetak9,615,633 bp[2]
Kraj9,617,680 bp[2]
Obrazac RNK ekspresije
Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija GO:0001948, GO:0016582 vezivanje za proteine
vezivanje sa RNK
5S rRNA binding
Ćelijska komponenta kondenzovani nuklearni hromosom
Jedarce
jedro
Endoplazmatski retikulum
preribosome, large subunit precursor
fibrillar center
Biološki proces ribosomal large subunit export from nucleus
mitotic metaphase plate congression
ribosome biogenesis
hematopoietic progenitor cell differentiation
endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ribosomal large subunit assembly
ribosomal large subunit biogenesis
protein localization to nucleolus
regulation of signal transduction by p53 class mediator
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_015169

NM_021511

RefSeq (bjelančevina)

NP_055984

NP_067486

Lokacija (UCSC)Chr 8: 66.43 – 66.43 MbChr 1: 9.62 – 9.62 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Aminokiselinska sekvenca

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Dužina polipeptidnog lanca je 365 aminokiselina, а molekulska težina 41.193 Da.[8]

1020304050
MEGQSVEELLAKAEQDEAEKLQRITVHKELELQFDLGNLLASDRNPPTGL
RCAGPTPEAELQALARDNTQLLINQLWQLPTERVEEAIVARLPEPTTRLP
REKPLPRPRPLTRWQQFARLKGIRPKKKTNLVWDEVSGQWRRRWGYQRAR
DDTKEWLIEVPGNADPLEDQFAKRIQAKKERVAKNELNRLRNLARAHKMQ
LPSAAGLHPTGHQSKEELGRAMQVAKVSTASVGRFQERLPKEKVPRGSGK
KRKFQPLFGDFAAEKKNQLELLRVMNSKKPQLDVTRATNKQMREEDQEEA
AKRRKMSQKGKRKGGRQGPGGKRKGGPPSQGGKRKGGLGGKMNSGPPGLG
GKRKGGQRPGGKRRK

Reference

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000179041 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000061024 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Nagase T, Miyajima N, Tanaka A, Sazuka T, Seki N, Sato S, Tabata S, Ishikawa K, Kawarabayasi Y, Kotani H, et al. (Jul 1995). "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (1): 37–43. doi:10.1093/dnares/2.1.37. PMID 7788527.
  6. ^ Tsuno A, Miyoshi K, Tsujii R, Miyakawa T, Mizuta K (Mar 2000). "RRS1, a Conserved Essential Gene, Encodes a Novel Regulatory Protein Required for Ribosome Biogenesis in Saccharomyces cerevisiae". Mol Cell Biol. 20 (6): 2066–74. doi:10.1128/MCB.20.6.2066-2074.2000. PMC 110823. PMID 10688653.
  7. ^ "Entrez Gene: RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)".
  8. ^ "UniProt, Q15050" (jezik: engleski). Pristupljeno 21. 9. 2021.

Dopunska literatura

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