RGCC

Regulator ćelijskog ciklusa RGCC (RGCC), znan i kao odgovorni gen za protrinski komplement 3 (RGC-32) je protein koji je kod ljudi kodiran genom RGCC.

RGCC
Identifikatori
Aliasi	RGCC
Vanjski ID-jevi	OMIM: 610077 MGI: 1913464 HomoloGene: 8544 GeneCards: RGCC
Lokacija gena (čovjek) Hrom. Hromosom 13 (čovjek) Bend 13q14.11 Početak 41,457,550 bp Kraj 41,470,871 bp
Lokacija gena (miš) Hrom. Hromosom 14 (miš) Bend 14|14 D3 Početak 79,526,196 bp Kraj 79,539,085 bp
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • R-SMAD binding • protein kinase activator activity • GO:0001948, GO:0016582 vezivanje za proteine • protein kinase binding Ćelijska komponenta • citoplazma • centrosom • centar organizacije mikrotubula • citoskelet • jedro • citosol • Jedarce Biološki proces • positive regulation of collagen biosynthetic process • negative regulation of blood vessel endothelial cell migration • negative regulation of cell-cell adhesion mediated by cadherin • complement activation • positive regulation of extracellular matrix assembly • positive regulation of DNA-binding transcription factor activity • negative regulation of mitotic cell cycle phase transition • positive regulation of epithelial to mesenchymal transition • positive regulation of extracellular matrix constituent secretion • regulation of cell cycle • negative regulation of endothelial cell proliferation • positive regulation of endothelial cell apoptotic process • GO:1901313 positive regulation of gene expression • positive regulation of DNA biosynthetic process • negative regulation of angiogenesis • ćelijski ciklus • fibroblast activation • negative regulation of exit from mitosis • positive regulation of mitotic nuclear division • cellular response to hypoxia • negative regulation of fibroblast growth factor production • positive regulation of stress fiber assembly • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • negative regulation of cell population proliferation • activation of protein kinase activity • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest • positive regulation of cyclin-dependent protein serine/threonine kinase activity • positive regulation of G1/S transition of mitotic cell cycle Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	28984	66214
Ensembl	ENSG00000102760	ENSMUSG00000022018
UniProt	Q9H4X1	Q9DBX1
RefSeq (mRNK)	NM_014059	NM_025427
RefSeq (bjelančevina)	NP_054778	NP_079703
Lokacija (UCSC)	Chr 13: 41.46 – 41.47 Mb	Chr 14: 79.53 – 79.54 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 137 aminokiselina, a molekulska težina 14.559 Da..

10		20		30		40		50
MKPPAAQGSP		AAAAAAAPAL		DSAAAEDLSD		ALCEFDAVLA		DFASPFHERH
FHYEEHLERM		KRRSSASVSD		SSGFSDSESA		DSLYRNSFSF		SDEKLNSPTD
STPALLSATV		TPQKAKLGDT		KELEAFIADL		DKTLASM

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

Funkcija

Smatra se da ovaj gen regulira napredovanje ćelijskog ciklusa. Izaziva ga p53, kao odgovor na oštećenje DNK, ili subrazgrađujuće nivoe proteinskog sistema komplementa koji rezultiraju aktivacijom ćelijskog ciklusa. Kodirani protein se lokalizira u citoplazmi, tokom interfaze i u centrosomima tokom mitoza. Protein formira kompleks s polo-lika kinaza 1. Protein se također translocira u jedro, kao odgovor na liječenje proteinima komplementnog sistema, a može se povezati i povećati aktivnost kinaze ciklusa ćelijske diobe dva proteina. U različitim testovima i tipovima ćelija pokazalo se da prekomjerna ekspresija ovog proteina aktivira ili suzbija napredovanje ćelijskog ciklusa.

Dopunska literatura

• Fosbrink M, Niculescu F, Rus H (2005). "The role of c5b-9 terminal complement complex in activation of the cell cycle and transcription". Immunol. Res. 31 (1): 37–46. doi:10.1385/IR:31:1:37. PMID 15591621.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Badea TC, Niculescu FI, Soane L, et al. (1998). "Molecular cloning and characterization of RGC-32, a novel gene induced by complement activation in oligodendrocytes". J. Biol. Chem. 273 (41): 26977–81. doi:10.1074/jbc.273.41.26977. PMID 9756947.
• Badea T, Niculescu F, Soane L, et al. (2002). "RGC-32 increases p34CDC2 kinase activity and entry of aortic smooth muscle cells into S-phase". J. Biol. Chem. 277 (1): 502–8. doi:10.1074/jbc.M109354200. PMID 11687586.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Fosbrink M, Cudrici C, Niculescu F, et al. (2005). "Overexpression of RGC-32 in colon cancer and other tumors". Exp. Mol. Pathol. 78 (2): 116–22. doi:10.1016/j.yexmp.2004.11.001. PMID 15713436.
• Tanaka T, Takada H, Nomura A, et al. (2005). "Distinct gene expression patterns of peripheral blood cells in hyper-IgE syndrome". Clin. Exp. Immunol. 140 (3): 524–31. doi:10.1111/j.1365-2249.2005.02805.x. PMC 1809394. PMID 15932515.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.