RAP1GAP2

RAP1 GTPazno aktivirajući protein 2 je protein koji je kod ljudi kodiran genom RAP1GAP2.

RAP1GAP2
Identifikatori
Aliasi	RAP1GAP2
Vanjski ID-jevi	MGI: 3028623 HomoloGene: 56695 GeneCards: RAP1GAP2
Lokacija gena (čovjek) Hrom. Hromosom 17 (čovjek) Bend 17p13.3 Početak 2,755,705 bp Kraj 3,037,741 bp
Lokacija gena (miš) Hrom. Hromosom 11 (miš) Bend 11|11 B5 Početak 74,274,182 bp Kraj 74,501,741 bp
Ontologija gena Molekularna funkcija • GO:0001948, GO:0016582 vezivanje za proteine • GO:0005097, GO:0005099, GO:0005100 GTPase activator activity Ćelijska komponenta • perinuklearno područje citoplazme • neuron projection • centrosom • ćelijska membrana • Jedarna membrana • citoplazma • citosol Biološki proces • regulation of cell size • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • negative regulation of neuron projection development • regulation of small GTPase mediated signal transduction Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	23108	380711
Ensembl	ENSG00000132359	ENSMUSG00000038807
UniProt	Q684P5	Q5SVL6
RefSeq (mRNK)	NM_001100398 NM_015085 NM_001330058	NM_001015046 NM_001364131 NM_001364132
RefSeq (bjelančevina)	NP_001093868 NP_001316987 NP_055900	NP_001015046 NP_001351060 NP_001351061 NP_001388587
Lokacija (UCSC)	Chr 17: 2.76 – 3.04 Mb	Chr 11: 74.27 – 74.5 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Ovaj gen kodira GTPaza-aktivirajući protein da aktivira mali protein koji veže guanin-nukleotid Rap1 u trombocitima. Protein stupa u interakciju sa sinaptotagminolikim proteinom 1 i Rab27 i reguliraju izlučivanje gustih granula iz trombocita na mjestima oštećenja endotela. Za ovaj gen je pronađeno više alternativnih varijanti transkripta koje kodiraju različite izoforme. [obezbedio RefSeq, septembar 2009.].

Dužina polipeptidnog lanca je 730 aminokiselina, a molekulska težina 80.056.

Aminokiselinska sekvenca

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

10		20		30		40		50
MFGRKRSVSF		GGFGWIDKTM		LASLKVKKQE		LANSSDATLP		DRPLSPPLTA
PPTMKSSEFF		EMLEKMQGIK		LEEQKPGPQK		NKDDYIPYPS		IDEVVEKGGP
YPQVILPQFG		GYWIEDPENV		GTPTSLGSSI		CEEEEEDNLS		PNTFGYKLEC
KGEARAYRRH		FLGKDHLNFY		CTGSSLGNLI		LSVKCEEAEG		IEYLRVILRS
KLKTVHERIP		LAGLSKLPSV		PQIAKAFCDD		AVGLRFNPVL		YPKASQMIVS
YDEHEVNNTF		KFGVIYQKAR		QTLEEELFGN		NEESPAFKEF		LDLLGDTITL
QDFKGFRGGL		DVTHGQTGVE		SVYTTFRDRE		IMFHVSTKLP		FTDGDAQQLQ
RKRHIGNDIV		AIIFQEENTP		FVPDMIASNF		LHAYIVVQVE		TPGTETPSYK
VSVTAREDVP		TFGPPLPSPP		VFQKGPEFRE		FLLTKLTNAE		NACCKSDKFA
KLEDRTRAAL		LDNLHDELHA		HTQAMLGLGP		EEDKFENGGH		GGFLESFKRA
IRVRSHSMET		MVGGQKKSHS		GGIPGSLSGG		ISHNSMEVTK		TTFSPPVVAA
TVKNQSRSPI		KRRSGLFPRL		HTGSEGQGDS		RARCDSTSST		PKTPDGGHSS
QEIKSETSSN		PSSPEICPNK		EKPFMKLKEN		GRAISRSSSS		TSSVSSTAGE
GEAMEEGDSG		GSQPSTTSPF		KQEVFVYSPS		PSSESPSLGA		AATPIIMSRS
PTDAKSRNSP		RSNLKFRFDK		LSHASSGAGH

Dopunska literatura

• Neumüller O, Hoffmeister M, Babica J, Prelle C, Gegenbauer K, Smolenski AP (august 2009). "Synaptotagmin-like protein 1 interacts with the GTPase-activating protein Rap1GAP2 and regulates dense granule secretion in platelets". Blood. 114 (7): 1396–404. doi:10.1182/blood-2008-05-155234. hdl:10197/5848. PMID 19528539.
• Aouizerat BE, Vittinghoff E, Musone SL, Pawlikowska L, Kwok PY, Olgin JE, Tseng ZH (juni 2011). "GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease". BMC Cardiovascular Disorders. 11: 29. doi:10.1186/1471-2261-11-29. PMC 3141757. PMID 21658281.
• Balduini A, Pecci A, Lova P, Arezzi N, Marseglia C, Bellora F, Perotti C, Balduini C, Balduini CL, Torti M (oktobar 2004). "Expression, activation, and subcellular localization of the Rap1 GTPase in cord blood-derived human megakaryocytes". Experimental Cell Research. 300 (1): 84–93. doi:10.1016/j.yexcr.2004.07.011. PMID 15383317.
• Kimura T, Mogi C, Sato K, Tomura H, Ohta H, Im DS, Kuwabara A, Kurose H, Murakami M, Okajima F (oktobar 2011). "p2y5/LPA(6) attenuates LPA(1)-mediated VE-cadherin translocation and cell-cell dissociation through G(12/13) protein-Src-Rap1". Cardiovascular Research. 92 (1): 149–58. doi:10.1093/cvr/cvr154. PMID 21632882.
• Schultess J, Danielewski O, Smolenski AP (april 2005). "Rap1GAP2 is a new GTPase-activating protein of Rap1 expressed in human platelets". Blood. 105 (8): 3185–92. doi:10.1182/blood-2004-09-3605. PMID 15632203.
• Hoffmeister M, Riha P, Neumüller O, Danielewski O, Schultess J, Smolenski AP (januar 2008). "Cyclic nucleotide-dependent protein kinases inhibit binding of 14-3-3 to the GTPase-activating protein Rap1GAP2 in platelets" (PDF). The Journal of Biological Chemistry. 283 (4): 2297–306. doi:10.1074/jbc.M706825200. PMID 18039662. S2CID 20190382.