Aminokiselinska sekvenca
uredi
Dužina polipeptidnog lanca je 1.075 aminokiselina , а molekulska težina 117.455 Da .[ 8]
10 20 30 40 50 MFYGTHFIMS PPTKSKLKRQ SQLLSSMLSR TLSYKYRDLD STFSSLGASD DPAELSTQLS APGVLKVFGD SVCTGTHYKS VLATGTSSAR ELVKEALERY ALDPRQAGQY VLCDVVGQAG DAGQRWQARC FRVFGDSEKP LLIQELWKPR EGLSRRFELR KRSDVEELAA KEVDTITAGI NAQARRLQRS RAKGTPTPAL GDARSSPPPR LRRTVSETSL SPVNALPAAA QGPEEPGPDA MRYSLYQSPH LLLLQGYSQQ HDSLVYVLNR DRHTVGQRTP SSKPSISLSA PDILPLHCTI RRQPLPDSGQ AAGRLVLEPI PGAHISVNFS EVGHRTVVLH HGDLLSLGLY YLLLFKDPAQ AQPLPARALA RLRAVPQSCR LCGAALGARG AASPTQAALP RRQQLLLEFE PHLEDTLLQR IMTLIEPGGD DHKLTPAFLL CLCIQHSATH FQPGTFGQLL LKIARLIRET VWEKTKELAE KQAQLQEPIS LASCAMADLV PDLQPILFWM SNSIELLYFI QQKCPLYMQS MEEQLDITGS KESLFSCTLT ASEEAMAVLE EVVLYAFQQC VYYVSKSLYI CLPALLECPP FQTERRESWS SAPELPEELR RVVSVYQAAL DLLRQLQVHP EVASQMLAYL FFFSGTLLLN QLLDRGPSLS CFHWPRGVQA CARLQQLLEW MRSAGFGAAG EHFFQKLSCT LNLLATPRAQ LIQMSWTALR AAFPALSPAQ LHRLLTHYQL ASAMGPMSTW EPGAQDSPEA FRSEDVLESY ENPPPIVLPS DGFQVDLEAN CLDDSIYQHL LYVRHFLWGL RSRASPGSPG RPGSGASQPV CPEGMHHVVL DGHLEAPSCP LAPRDPGPAA REVAPERTLP LRGAPWAQAP PGRQPSRGGS QAGPPHTDSS CLLTPPSTPL GPEPGDPDWP ESGGPCGKAL PERQRNGLSG LRGAAPEGDS AALAEESPPA PSSRSSSTED FCYVFTVELE RGPSGLGMGL IDGMHTHLGA PGLYIQTLLP GSPAAADGRL SLGDRILEVN GSSLLGLGYL RAVDLIRHGG KKMRFLVAKS DVETAKKIHF RTPPL
^ a b c GRCh38: Ensembl release 89: ENSG00000157927 - Ensembl , maj 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029576 - Ensembl , maj 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Zhang Z, Rehmann H, Price LS, Riedl J, Bos JL (Sep 2005). "AF6 negatively regulates Rap1-induced cell adhesion" . J Biol Chem . 280 (39): 33200–5. doi :10.1074/jbc.M505057200 PMID 16051602 . ^ Smolen GA, Schott BJ, Stewart RA, Diederichs S, Muir B, Provencher HL, Look AT, Sgroi DC, Peterson RT, Haber DA (Sep 2007). "A Rap GTPase interactor, RADIL, mediates migration of neural crest precursors" . Genes Dev . 21 (17): 2131–6. doi :10.1101/gad.1561507 . PMC 1950852 PMID 17704304 . ^ "Entrez Gene: FLJ10324 hypothetical protein FLJ10324" .^ "UniProt, Q96JH8" (jezik: engleski). Pristupljeno 28. 9. 2021 .
Dopunska literatura
uredi
Ahmed SM, Daulat AM, Meunier A, Angers S (februar 2010). "G protein betagamma subunits regulate cell adhesion through Rap1a and its effector Radil" . J. Biol. Chem . 285 (9): 6538–51. doi :10.1074/jbc.M109.069948 PMC 2825450 PMID 20048162 . Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs" . Genome Res . 11 (3): 422–35. doi :10.1101/gr.GR1547R . PMC 311072 PMID 11230166 . Nagase T, Nakayama M, Nakajima D, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro" . DNA Res . 8 (2): 85–95. doi :10.1093/dnares/8.2.85 PMID 11347906 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7" . Nature . 424 (6945): 157–64. doi :10.1038/nature01782 PMID 12853948 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 PMID 14702039 . Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol . 22 (6): 707–16. doi :10.1038/nbt971 . PMID 15146197 . S2CID 27764390 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8. doi :10.1038/nature04209 . PMID 16189514 . S2CID 4427026 . Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes" . Genome Res . 16 (1): 55–65. doi :10.1101/gr.4039406 . PMC 1356129 PMID 16344560 . Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry" . Mol. Syst. Biol . 3 (1): 89. doi :10.1038/msb4100134 . PMC 1847948 PMID 17353931 .
