RABGAP1

Protein 1 aktivirajuće RAB GTPaze je protein koji je kod ljudi kodiran genom RABGAP1.

RABGAP1
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 4NC6
Identifikatori
Aliasi	RABGAP1
Vanjski ID-jevi	OMIM: 615882 MGI: 2385139 HomoloGene: 49301 GeneCards: RABGAP1
Lokacija gena (čovjek) Hrom. Hromosom 9 (čovjek) Bend 9q33.2-q33.3 Početak 122,940,833 bp Kraj 123,104,866 bp
Lokacija gena (miš) Hrom. Hromosom 2 (miš) Bend 2|2 B Početak 37,333,291 bp Kraj 37,456,466 bp
Ontologija gena Molekularna funkcija • vezivanje tubulina • GO:0001948, GO:0016582 vezivanje za proteine • GO:0005097, GO:0005099, GO:0005100 GTPase activator activity Ćelijska komponenta • citoplazma • citosol • centrosom • citoskelet • microtubule associated complex • centar organizacije mikrotubula • Endomembranski sistem Biološki proces • regulation of cilium assembly • ćelijski ciklus • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • GO:0032861, GO:0032862, GO:0032856 activation of GTPase activity • regulation of vesicle fusion • intracellular protein transport • GO:0043087, GO:0032313, GO:0032319, GO:0032314, GO:0043088 regulation of GTPase activity Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	23637	227800
Ensembl	ENSG00000011454	ENSMUSG00000035437
UniProt	Q9Y3P9	A2AWA9
RefSeq (mRNK)	NM_012197	NM_001033960 NM_146121 NM_001362956 NM_001362957 NM_001362958
RefSeq (bjelančevina)	NP_036329	NP_001029132 NP_666233 NP_001349885 NP_001349886 NP_001349887
Lokacija (UCSC)	Chr 9: 122.94 – 123.1 Mb	Chr 2: 37.33 – 37.46 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 1.069aminokiselina, а molekulska težina 121.737 Da.

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MDDKASVGKI		SVSSDSVSTL		NSEDFVLVSR		QGDETPSTNN		GSDDEKTGLK
IVGNGSEQQL		QKELADVLMD		PPMDDQPGEK		ELVKRSQLDG		EGDGPLSNQL
SASSTINPVP		LVGLQKPEMS		LPVKPGQGDS		EASSPFTPVA		DEDSVVFSKL
TYLGCASVNA		PRSEVEALRM		MSILRSQCQI		SLDVTLSVPN		VSEGIVRLLD
PQTNTEIANY		PIYKILFCVR		GHDGTPESDC		FAFTESHYNA		ELFRIHVFRC
EIQEAVSRIL		YSFATAFRRS		AKQTPLSATA		APQTPDSDIF		TFSVSLEIKE
DDGKGYFSAV		PKDKDRQCFK		LRQGIDKKIV		IYVQQTTNKE		LAIERCFGLL
LSPGKDVRNS		DMHLLDLESM		GKSSDGKSYV		ITGSWNPKSP		HFQVVNEETP
KDKVLFMTTA		VDLVITEVQE		PVRFLLETKV		RVCSPNERLF		WPFSKRSTTE
NFFLKLKQIK		QRERKNNTDT		LYEVVCLESE		SERERRKTTA		SPSVRLPQSG
SQSSVIPSPP		EDDEEEDNDE		PLLSGSGDVS		KECAEKILET		WGELLSKWHL
NLNVRPKQLS		SLVRNGVPEA		LRGEVWQLLA		GCHNNDHLVE		KYRILITKES
PQDSAITRDI		NRTFPAHDYF		KDTGGDGQDS		LYKICKAYSV		YDEEIGYCQG
QSFLAAVLLL		HMPEEQAFSV		LVKIMFDYGL		RELFKQNFED		LHCKFYQLER
LMQEYIPDLY		NHFLDISLEA		HMYASQWFLT		LFTAKFPLYM		VFHIIDLLLC
EGISVIFNVA		LGLLKTSKDD		LLLTDFEGAL		KFFRVQLPKR		YRSEENAKKL
MELACNMKIS		QKKLKKYEKE		YHTMREQQAQ		QEDPIERFER		ENRRLQEANM
RLEQENDDLA		HELVTSKIAL		RKDLDNAEEK		ADALNKELLM		TKQKLIDAEE
EKRRLEEESA		QLKEMCRREL		DKAESEIKKN		SSIIGDYKQI		CSQLSERLEK
QQTANKVEIE		KIRQKVDDCE		RCREFFNKEG		RVKGISSTKE		VLDEDTDEEK
ETLKNQLREM		ELELAQTKLQ		LVEAECKIQD		LEHHLGLALN		EVQAAKKTWF
NRTLSSIKTA		TGVQGKETC

Dopunska literatura

• Caratù G, Allegra D, Bimonte M, Schiattarella GG, D'Ambrosio C, Scaloni A, Napolitano M, Russo T, Zambrano N (februar 2007). "Identification of the ligands of protein interaction domains through a functional approach". Molecular & Cellular Proteomics. 6 (2): 333–45. doi:10.1074/mcp.M600289-MCP200. PMID 17124247.
• Echard A, Opdam FJ, de Leeuw HJ, Jollivet F, Savelkoul P, Hendriks W, Voorberg J, Goud B, Fransen JA (novembar 2000). "Alternative splicing of the human Rab6A gene generates two close but functionally different isoforms". Molecular Biology of the Cell. 11 (11): 3819–33. doi:10.1091/mbc.11.11.3819. PMC 15039. PMID 11071909.
• Ishibashi K, Kanno E, Itoh T, Fukuda M (januar 2009). "Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity". Genes to Cells. 14 (1): 41–52. doi:10.1111/j.1365-2443.2008.01251.x. PMID 19077034. S2CID 26454981.
• Opdam FJ, Echard A, Croes HJ, van den Hurk JA, van de Vorstenbosch RA, Ginsel LA, Goud B, Fransen JA (august 2000). "The small GTPase Rab6B, a novel Rab6 subfamily member, is cell-type specifically expressed and localised to the Golgi apparatus". Journal of Cell Science. 113 ( Pt 15) (15): 2725–35. PMID 10893188.
• Cuif MH, Possmayer F, Zander H, Bordes N, Jollivet F, Couedel-Courteille A, Janoueix-Lerosey I, Langsley G, Bornens M, Goud B (april 1999). "Characterization of GAPCenA, a GTPase activating protein for Rab6, part of which associates with the centrosome". The EMBO Journal. 18 (7): 1772–82. doi:10.1093/emboj/18.7.1772. PMC 1171263. PMID 10202141.