Aminokiselinska sekvenca
uredi
Dužina polipeptidnog lanca je 3.088 aminokiselina, а molekulska težina 340.635 Da.[7]
| 10 | | 20 | | 30 | | 40 | | 50 |
|---|
| MEEFLQRAKS | | KLNRSKRLEK | | VHVVIGPKSC | | DLDSLISTFT | | YAYFLDKVSP |
| PGVLCLPVLN | | IPRTEFNYFT | | ETRFILEELN | | ISESFHIFRD | | EINLHQLNDE |
| GKLSITLVGS | | SVLASEDKTL | | ESAVVKVINP | | VEQSDANVEF | | RESSSSLVLK |
| EILQEAPELI | | TEQLAHRLRG | | SILFKWMTME | | SEKISEKQEE | | ILSILEEKFP |
| NLPPREDIIN | | VLQETQFSAQ | | GLSIEQTMLK | | DLKELSDGEI | | KVAISTVSMN |
| LENCLFHSNI | | TSDLKAFTDK | | FGFDVLILFS | | SYLSEEQQPR | | RQIAVYSENM |
| ELCSQICCEL | | EECQNPCLEL | | EPFDCGCDEI | | LVYQQEDPSV | | TCDQVVLVVK |
| EVINRRCPEM | | VSNSRTSSTE | | AVAGSAPLSQ | | GSSGIMELYG | | SDIEPQPSSV |
| NFIENPPDLN | | DSNQAQVDAN | | VDLVSPDSGL | | ATIRSSRSSK | | ESSVFLSDDS |
| PVGEGAGPHH | | TLLPGLDSYS | | PIPEGAVAEE | | HAWSGEHGEH | | FDLFNFDPAP |
| MASGQSQQSS | | HSADYSPADD | | FFPNSDLSEG | | QLPAGPEGLD | | GMGTNMSNYS |
| SSSLLSGAGK | | DSLVEHDEEF | | VQRQDSPRDN | | SERNLSLTDF | | VGDESPSPER |
| LKNTGKRIPP | | TPMNSLVESS | | PSTEEPASLY | | TEDMTQKATD | | TGHMGPPQTH |
| ARCSSWWGGL | | EIDSKNIADA | | WSSSEQESVF | | QSPESWKEHK | | PSSIDRRASD |
| SVFQPKSLEF | | TKSGPWESEF | | GQPELGSNDI | | QDKNEESLPF | | QNLPMEKSPL |
| PNTSPQGTNH | | LIEDFASLWH | | SGRSPTAMPE | | PWGNPTDDGE | | PAAVAPFPAW |
| SAFGKEDHDE | | ALKNTWNLHP | | TSSKTPSVRD | | PNEWAMAKSG | | FAFSSSELLD |
| NSPSEINNEA | | APEIWGKKNN | | DSRDHIFAPG | | NPSSDLDHTW | | TNSKPPKEDQ |
| NGLVDPKTRG | | KVYEKVDSWN | | LFEENMKKGG | | SDVLVPWEDS | | FLSYKCSDYS |
| ASNLGEDSVP | | SPLDTNYSTS | | DSYTSPTFAG | | DEKETEHKPF | | AKEEGFESKD |
| GNSTAEETDI | | PPQSLQQSSR | | NRISSGPGNL | | DMWASPHTDN | | SSEINTTHNL |
| DENELKTEHT | | DGKNISMEDD | | VGESSQSSYD | | DPSMMQLYNE | | TNRQLTLLHS |
| STNSRQTAPD | | SLDLWNRVIL | | EDTQSTATIS | | DMDNDLDWDD | | CSGGAAIPSD |
| GQTEGYMAEG | | SEPETRFTVR | | QLEPWGLEYQ | | EANQVDWELP | | ASDEHTKDSA |
| PSEHHTLNEK | | SGQLIANSIW | | DSVMRDKDMS | | SFMLPGSSHI | | TDSEQRELPP |
| EIPSHSANVK | | DTHSPDAPAA | | SGTSESEALI | | SHLDKQDTER | | ETLQSDAASL |
| ATRLENPGYF | | PHPDPWKGHG | | DGQSESEKEA | | QGATDRGHLD | | EEEVIASGVE |
| NASGISEKGQ | | SDQELSSLVA | | SEHQEICIKS | | GKISSLAVTF | | SPQTEEPEEV |
| LEYEEGSYNL | | DSRDVQTGMS | | ADNLQPKDTH | | EKHLMSQRNS | | GETTETSDGM |
| NFTKYVSVPE | | KDLEKTEECN | | FLEPENVGGG | | PPHRVPRSLD | | FGDVPIDSDV |
| HVSSTCSEIT | | KNLDVKGSEN | | SLPGAGSSGN | | FDRDTISSEY | | THSSASSPEL |
| NDSSVALSSW | | GQQPSSGYQE | | ENQGNWSEQN | | HQESELITTD | | GQVEIVTKVK |
| DLEKNRINEF | | EKSFDRKTPT | | FLEIWNDSVD | | GDSFSSLSSP | | ETGKYSEHSG |
| THQESNLIAS | | YQEKNEHDIS | | ATVQPEDARV | | ISTSSGSDDD | | SVGGEESIEE |
| EIQVANCHVA | | EDESRAWDSL | | NESNKFLVTA | | DPKSENIYDY | | LDSSEPAENE |
| NKSNPFCDNQ | | QSSPDPWTFS | | PLTETEMQIT | | AVEKEKRSSP | | ETGTTGDVAW |
| QISPKASFPK | | NEDNSQLEML | | GFSADSTEWW | | KASPQEGRLI | | ESPFERELSD |
| SSGVLEINSS | | VHQNASPWGV | | PVQGDIEPVE | | THYTNPFSDN | | HQSPFLEGNG |
| KNSHEQLWNI | | QPRQPDPDAD | | KFSQLVKLDQ | | IKEKDSREQT | | FVSAAGDELT |
| PETPTQEQCQ | | DTMLPVCDHP | | DTAFTHAEEN | | SCVTSNVSTN | | EGQETNQWEQ |
| EKSYLGEMTN | | SSIATENFPA | | VSSPTQLIMK | | PGSEWDGSTP | | SEDSRGTFVP |
| DILHGNFQEG | | GQLASAAPDL | | WIDAKKPFSL | | KADGENPDIL | | THCEHDSNSQ |
| ASDSPDICHD | | SEAKQETEKH | | LSACMGPEVE | | SSELCLTEPE | | IDEEPIYEPG |
| REFVPSNAEL | | DSENATVLPP | | IGYQADIKGS | | SQPASHKGSP | | EPSEINGDNS |
| TGLQVSEKGA | | SPDMAPILEP | | VDRRIPRIEN | | VATSIFVTHQ | | EPTPEGDGSW |
| ISDSFSPESQ | | PGARALFDGD | | PHLSTENPAL | | VPDALLASDT | | CLDISEAAFD |
| HSFSDASGLN | | TSTGTIDDMS | | KLTLSEGHPE | | TPVDGDLGKQ | | DICSSEASWG |
| DFEYDVMGQN | | IDEDLLREPE | | HFLYGGDPPL | | EEDSLKQSLA | | PYTPPFDLSY |
| LTEPAQSAET | | IEEAGSPEDE | | SLGCRAAEIV | | LSALPDRRSE | | GNQAETKNRL |
| PGSQLAVLHI | | REDPESVYLP | | VGAGSNILSP | | SNVDWEVETD | | NSDLPAGGDI |
| GPPNGASKEI | | SELEEEKTIP | | TKEPEQIKSE | | YKEERCTEKN | | EDRHALHMDY |
| ILVNREENSH | | SKPETCEERE | | SIAELELYVG | | SKETGLQGTQ | | LASFPDTCQP |
| ASLNERKGLS | | AEKMSSKSDT | | RSSFESPAQD | | QSWMFLGHSE | | VGDPSLDARD |
| SGPGWSGKTV | | EPFSELGLGE | | GPQLQILEEM | | KPLESLALEE | | ASGPVSQSQK |
| SKSRGRAGPD | | AVTLQAVTHD | | NEWEMLSPQP | | VQKNMIPDTE | | MEEETEFLEL |
| GTRISRPNGL | | LSEDVGMDIP | | FEEGVLSPSA | | ADMRPEPPNS | | LDLNDTHPRR |
| IKLTAPNINL | | SLDQSEGSIL | | SDDNLDSPDE | | IDINVDELDT | | PDEADSFEYT |
| GHDPTANKDS | | GQESESIPEY | | TAEEEREDNR | | LWRTVVIGEQ | | EQRIDMKVIE |
| PYRRVISHGG | | YYGDGLNAII | | VFAACFLPDS | | SRADYHYVME | | NLFLYVISTL |
| ELMVAEDYMI | | VYLNGATPRR | | RMPGLGWMKK | | CYQMIDRRLR | | KNLKSFIIVH |
| PSWFIRTILA | | VTRPFISSKF | | SSKIKYVNSL | | SELSGLIPMD | | CIHIPESIIK |
| LDEELREASE | | AAKTSCLYND | | PEMSSMEKDI | | DLKLKEKP |
- ^ a b c GRCh38: Ensembl release 89: ENSG00000106772 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039126 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Machida T, Fujita T, Ooo ML, Ohira M, Isogai E, Mihara M, Hirato J, Tomotsune D, Hirata T, Fujimori M, Adachi W, Nakagawara A (Mar 2006). "Increased expression of proapoptotic BMCC1, a novel gene with the BNIP2 and Cdc42GAP homology (BCH) domain, is associated with favorable prognosis in human neuroblastomas". Oncogene. 25 (13): 1931–42. doi:10.1038/sj.onc.1209225. PMID 16288218.
- ^ "Entrez Gene: PRUNE2 prune homolog 2 (Drosophila)".
- ^ "UniProt, Q8WUY3". Pristupljeno 11. 9. 2021.
Dopunska literatura
uredi
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- Nagase T, Ishikawa K, Nakajima D, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 4 (2): 141–50. doi:10.1093/dnares/4.2.141. PMID 9205841.
- Venter JC, Adams MD, Myers EW, et al. (2001). "The sequence of the human genome". Science. 291 (5507): 1304–51. Bibcode:2001Sci...291.1304V. doi:10.1126/science.1058040. PMID 11181995.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
- Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
- Price ND, Trent J, El-Naggar AK, et al. (2007). "Highly accurate two-gene classifier for differentiating gastrointestinal stromal tumors and leiomyosarcomas". Proc. Natl. Acad. Sci. U.S.A. 104 (9): 3414–9. Bibcode:2007PNAS..104.3414P. doi:10.1073/pnas.0611373104. PMC 1805517. PMID 17360660.
