PRIC285
Interaktivni kompleks receptora A aktiviranog peroksisomskim proliferatorom 285 je ljudski gen.[5]
Protein kojega kodira ovaj gen je jedarni transkripcijski koaktivator za receptor alfa aktiviran proliferatorom peroksisoma. Kodirani protein sadrži cinkov prst i helikazu koja je čini se dijelom kompleksa interakcije receptora alfa koji aktivira proliferator peroksisoma. Ovaj gen je član porodice gena DNK2/NAM7 helikaza. Za ovaj gen pronađene su alternativno prerađene varijante transkripta koje kodiraju različite izoforme.[5]
Aminokiselinska sekvenca proteina
uredi- Simboli
C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MAVWEAEQLG | GLQRGDLLTP | PAPDGDGRTA | PLGQPPGAQL | YCPACLVTCH | ||||
| SQEAFENHCA | SSEHAQMVAF | DQALPWEHRS | PPPGLSKFEL | CPKPDLCEYG | ||||
| DACTKAHSAQ | ELQEWVRRTQ | AVELRGQAAW | QDGLVPYQER | LLAEYQRSSS | ||||
| EVLVLAETLD | GVRVTCNQPL | MYQAQERKTQ | YSWTFAVHSE | EPLLHVALLK | ||||
| QEPGADFSLV | APGLPPGRLY | ARGERFRVPS | STADFQVGVR | VQAASFGTFE | ||||
| QWVVFDFGRR | PVLLQKLGLQ | LGQGRRPGPC | RNLALGHPEE | MERWHTGNRH | ||||
| VVPGVERTAE | QTALMAKYKG | PALALEFNRS | SVASGPISPT | NYRQRMHQFL | ||||
| YEEEAAQQQL | VAKLTLRGQV | FLKTALQTPA | LNMLFAPPGA | LYAEVPVPSS | ||||
| LMPDTDQGFL | LGRAVSTALV | APVPAPDNTV | FEVRLERRAS | SEQALWLLLP | ||||
| ARCCLALGLQ | PEARLVLEVQ | FQIDPMTFRL | WHQAVDTLPE | EQLVVPDLPT | ||||
| CALPRPWSVP | PLRRGNRKQE | LAVALIAGWG | PGDGRRVPPL | LIYGPFGTGK | ||||
| TYTLAMASLE | VIRRPETKVL | ICTHTNSAAD | IYIREYFHSH | VSGGHPEATP | ||||
| LRVMYTDRPL | SQTDPVTLQY | CCLTDDRQAF | RPPTRAELAR | HRVVVTTTSQ | ||||
| ARELRVPVGF | FSHILIDEAA | QMLECEALTP | LAYASHGTRL | VLAGDHMQVT | ||||
| PRLFSVARAR | AAEHTLLHRL | FLCYQQETHE | VARQSRLVFH | ENYRCTDAIV | ||||
| SFISRHFYVA | KGNPIHARGK | VPPHPRHYPL | MFCHVAGSPD | RDMSMASWLN | ||||
| LAEIAQVVEK | VQEAYNTWPS | CWGGREQRCI | CVVSHGAQVS | ALRQELRRRD | ||||
| LGQVSVGSFE | ILPGRQFRVV | VLSTVHTCQS | LLSPGALAPE | FFTDARVLNT | ||||
| VLTRAQSQLV | VVGDAVALCS | FGACGKLWES | FIRECVERHS | VCPEGLSMEQ | ||||
| VEQGVAQRRR | WPPRGTQAGA | AGNWEAAPEP | VGDLAEEQAA | VVTAMVKAEP | ||||
| GDEALSPASR | DITATTAQTE | AAAAPAGDAV | KEDVVPGACA | AGAAAAAGVE | ||||
| STEAEDAEAD | FWPWDGELNA | DDAILRELLD | ESQKVMVTVG | EDGLLDTVAR | ||||
| PESLQQARLY | ENLPPAALRK | LLHAEPERYR | HCSFVPETFE | RASAIPLDDA | ||||
| SSGPIQVRGR | LDCGMAFAGD | EVLVQLLSGD | KAPEGRLRGR | VLGVLKRKRH | ||||
| ELAFVCRMDT | WDPRIMVPIN | GSVTKIFVAE | LKDPSQVPIY | SLRKGRLQRV | ||||
| GLERLTAEAR | HSRLFWVQIV | LWRQGFYYPL | GIVREVLPEA | STWEQGLRIL | ||||
| GLEYSLRVPP | SDQATITKVL | QKYHTELGRV | AGRREDCRAF | LTFTVDPQGA | ||||
| CNLDDALSVR | DLGPRCEVAV | HITDVASFVP | RDGVLDVEAR | RQGAAFYAPG | ||||
| REPVPMLPAS | LCQDVLSLLP | GRDRLAISLF | LTMEKASGQL | KSLRFAPSVV | ||||
| QSDRQLSYEE | AEEVIRQHPG | AGRELPARLD | SVDACVVAAC | YFSRLLRRHR | ||||
| LRSDCFYEQP | DEDGTLGFRA | AHIMVKEYMI | QFNRLVAEFL | VGSECTRTVT | ||||
| PLRWQPAPRS | QQLKALCEKH | GDRVPLSLHL | GHHLHGGGGS | PPDTRLHLLA | ||||
| SLWKQVQFAA | RTQDYEQMVD | LVTTDDMHPF | LAPAGRDLRK | ALERSAFGRC | ||||
| ARGHQQQGGH | YSLQVDWYTW | ATSPIRRYLD | VVLQRQILLA | LGHGGSAYSA | ||||
| RDIDGLCQAF | SLQHALAQSY | QRRARSLHLA | VQLKAQPLDK | LGFVVDVEAG | ||||
| SRCFRLLFPS | NRETLPDPCP | VPYGSLQLAE | HPHALAGRPG | LRLLWRRRVY | ||||
| SAQGSSPPLP | LPGTVPDPHT | LAVETALWKQ | LLELVELQRW | PEAAALIQEK | ||||
| GEASQRRELV | QVQRSHCGHF | LEVARELGSG | DTLQVQLGTS | LQHGFLVPSP | ||||
| QLWTVAPGFS | LCLEHVERPG | DCFSGRVYRA | PRDRYRDVDE | YACVWEPFCA | ||||
| LESATGAVAE | NDSVTLQHLS | VSWEASRTPQ | GQLQGAFRLE | AAFLEENCAD | ||||
| INFSCCYLCI | RLEGLPAPTA | SPRPGPSSLG | PGLNVDPGTY | TWVAHGQTQD | ||||
| WDQERRADRQ | EAPRRVHLFV | HHMGMEKVPE | EVLRPGTLFT | VELLPKQLPD | ||||
| LRKEEAVRGL | EEASPLVTSI | ALGRPVPQPL | CRVIPSRFLE | RQTYNIPGGR | ||||
| HKLNPSQNVA | VREALEKPFT | VIQGPPGTGK | TIVGLHIVFW | FHKSNQEQVQ | ||||
| PGGPPRGEKR | LGGPCILYCG | PSNKSVDVLA | GLLLRRMELK | PLRVYSEQAE | ||||
| ASEFPVPRVG | SRKLLRKSPR | EGRPNQSLRS | ITLHHRIRQA | PNPYSSEIKA | ||||
| FDTRLQRGEL | FSREDLVWYK | KVLWEARKFE | LDRHEVILCT | CSCAASASLK | ||||
| ILDVRQILVD | EAGMATEPET | LIPLVQFPQA | EKVVLLGDHK | QLRPVVKNER | ||||
| LQNLGLDRSL | FERYHEDAHM | LDTQYRMHEG | ICAFPSVAFY | KSKLKTWQGL | ||||
| RRPPSVLGHA | GKESCPVIFG | HVQGHERSLL | VSTDEGNENS | KANLEEVAEV | ||||
| VRITKQLTLG | RTVEPQDIAV | LTPYNAQASE | ISKALRREGI | AGVAVSSITK | ||||
| SQGSEWRYVL | VSTVRTCAKS | DLDQRPTKSW | LKKFLGFVVD | PNQVNVAVTR | ||||
| AQEGLCLIGD | HLLLRCCPLW | RSLLDFCEAQ | QTLVPAGQVR | VCRRPTMPS |
Reference
uredi- ^ a b c GRCh38: Ensembl release 89: ENSG00000130589 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027580 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: PRIC285 peroxisomal proliferator-activated receptor A interacting complex 285".
Dopunska literatura
uredi- Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
- Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
- Nagase T, Kikuno R, Hattori A, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (6): 347–55. doi:10.1093/dnares/7.6.347. PMID 11214970.
- Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
- Surapureddi S, Yu S, Bu H, et al. (2002). "Identification of a transcriptionally active peroxisome proliferator-activated receptor alpha -interacting cofactor complex in rat liver and characterization of PRIC285 as a coactivator". Proc. Natl. Acad. Sci. U.S.A. 99 (18): 11836–41. doi:10.1073/pnas.182426699. PMC 129355. PMID 12189208.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
- Tomaru T, Satoh T, Yoshino S, et al. (2006). "Isolation and characterization of a transcriptional cofactor and its novel isoform that bind the deoxyribonucleic acid-binding domain of peroxisome proliferator-activated receptor-gamma". Endocrinology. 147 (1): 377–88. doi:10.1210/en.2005-0450. PMID 16239304.