PLGLB2

PLGLB2
Identifikatori
Aliasi	PLGLB2
Vanjski ID-jevi	HomoloGene: 37652 GeneCards: PLGLB2
Lokacija gena (čovjek)
Hrom.	Hromosom 2 (čovjek)
Kraj	87,759,476 bp
Ortolozi
	5342
	n/a
	ENSG00000125551
	n/a
	Q02325
	n/a
	NM_002665
	n/a
	NP_001027564
	n/a
	Wikipodaci
Pogledaj/uredi – čovjek

Homolog 1 proteina pelino jest protein koji je kod ljudi kodiran genom PELI1 sa hromosoma 2.^[3]^[4]^[5]

Amiokiselininska sekvenca

Dužina polipeptidnog lanca je 418 aminokiselina, a molekulska težina 46.286 Da.^[6]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MFSPDQENHP	SKAPVKYGEL	IVLGYNGSLP	NGDRGRRKSR	FALFKRPKAN
GVKPSTVHIA	CTPQAAKAIS	NKDQHSISYT	LSRAQTVVVE	YTHDSNTDMF
QIGRSTESPI	DFVVTDTVPG	SQSNSDTQSV	QSTISRFACR	IICERNPPFT
ARIYAAGFDS	SKNIFLGEKA	AKWKTSDGQM	DGLTTNGVLV	MHPRNGFTED
SKPGIWREIS	VCGNVFSLRE	TRSAQQRGKM	VEIETNQLQD	GSLIDLCGAT
LLWRTAEGLS	HTPTVKHLEA	LRQEINAARP	QCPVGFNTLA	FPSMKRKDVV
DEKQPWVYLN	CGHVHGYHNW	GNKEERDGKD	RECPMCRSVG	PYVPLWLGCE
AGFYVDAGPP	THAFSPCGHV	CSEKTTAYWS	QIPLPHGTHT	FHAACPFCAH
QLAGEQGYIR	LIFQGPLD

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000125551 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Resch K, Jockusch H, Schmitt-John T (Apr 2001). "Assignment of homologous genes, Peli1/PELI1 and Peli2/PELI2, for the Pelle adaptor protein Pellino to mouse chromosomes 11 and 14 and human chromosomes 2p13.3 and 14q21, respectively, by physical and radiation hybrid mapping". Cytogenet Cell Genet. 92 (1–2): 172–174. doi:10.1159/000056895. PMID 11306823. S2CID 83911010.
^ Choi KC, Lee YS, Lim S, Choi HK, Lee CH, Lee EK, Hong S, Kim IH, Kim SJ, Park SH (Sep 2006). "Smad6 negatively regulates interleukin 1-receptor-Toll-like receptor signaling through direct interaction with the adaptor Pellino-1". Nat Immunol. 7 (10): 1057–1065. doi:10.1038/ni1383. PMID 16951688. S2CID 9646386.
^ "Entrez Gene: PELI1 pellino homolog 1 (Drosophila)".
^ "UniProt, Q96FA3" (jezik: engleski). Pristupljeno 14. 11. 2021.

Dopunska literatura

Rich T, Allen RL, Lucas AM, et al. (2001). "Pellino-related sequences from Caenorhabditis elegans and Homo sapiens". Immunogenetics. 52 (1–2): 145–149. doi:10.1007/s002510000249. PMID 11132151. S2CID 13467302.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Jiang Z, Johnson HJ, Nie H, et al. (2003). "Pellino 1 is required for interleukin-1 (IL-1)-mediated signaling through its interaction with the IL-1 receptor-associated kinase 4 (IRAK4)-IRAK-tumor necrosis factor receptor-associated factor 6 (TRAF6) complex". J. Biol. Chem. 278 (13): 10952–10956. doi:10.1074/jbc.M212112200. PMID 12496252.
Jensen LE, Whitehead AS (2003). "Pellino2 activates the mitogen activated protein kinase pathway". FEBS Lett. 545 (2–3): 199–202. doi:10.1016/S0014-5793(03)00533-7. PMID 12804775. S2CID 46719284.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Butler MP, Hanly JA, Moynagh PN (2005). "Pellino3 is a novel upstream regulator of p38 MAPK and activates CREB in a p38-dependent manner" (PDF). J. Biol. Chem. 280 (30): 27759–27768. doi:10.1074/jbc.M500756200. PMID 15917247. S2CID 30374239.
Butler MP, Hanly JA, Moynagh PN (2007). "Kinase-active interleukin-1 receptor-associated kinases promote polyubiquitination and degradation of the Pellino family: direct evidence for PELLINO proteins being ubiquitin-protein isopeptide ligases". J. Biol. Chem. 282 (41): 29729–29737. doi:10.1074/jbc.M704558200. PMID 17675297.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000125551 - Ensembl, maj 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11306823-3] Resch K, Jockusch H, Schmitt-John T (Apr 2001). "Assignment of homologous genes, Peli1/PELI1 and Peli2/PELI2, for the Pelle adaptor protein Pellino to mouse chromosomes 11 and 14 and human chromosomes 2p13.3 and 14q21, respectively, by physical and radiation hybrid mapping". Cytogenet Cell Genet. 92 (1–2): 172–174. doi:10.1159/000056895. PMID 11306823. S2CID 83911010.

[pmid16951688-4] Choi KC, Lee YS, Lim S, Choi HK, Lee CH, Lee EK, Hong S, Kim IH, Kim SJ, Park SH (Sep 2006). "Smad6 negatively regulates interleukin 1-receptor-Toll-like receptor signaling through direct interaction with the adaptor Pellino-1". Nat Immunol. 7 (10): 1057–1065. doi:10.1038/ni1383. PMID 16951688. S2CID 9646386.

[entrez-5] "Entrez Gene: PELI1 pellino homolog 1 (Drosophila)".

[UniProt-6] "UniProt, Q96FA3" (jezik: engleski). Pristupljeno 14. 11. 2021.

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