PKIB
Inhibitor beta cAMP-ovisne protein-kinaze jest protein koji je kod ljudi kodiran genom PKIB.[5][6]
Aminokiselinska sekvenca
urediDužina polipeptidnog lanca je 78 aminokiselina, а molekulska težina 8.468 Da.[7]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MRTDSSKMTD | VESGVANFAS | SARAGRRNAL | PDIQSSAATD | GTSDLPLKLE | ||||
| ALSVKEDAKE | KDEKTTQDQL | EKPQNEEK |
Funkcija
urediProtein kodiran ovim genom član je porodice proteina ovisnih o cikličnom adenozin-monofosfatu inhibitora protein-kinaze. Studije sličnog proteina na pacovima sugeriraju da ovaj protein može stupiti u interakciju s katalitskom podjedinicom cAMP-ovisne protein-kinaze i djelovati kao kompetitivni inhibitor. Prijavljena su najmanje tri alternativno prerađene varijante transkripta koje kodiraju isti protein.[6]
Reference
uredi- ^ a b c GRCh38: Ensembl release 89: ENSG00000135549 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000019876 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Zheng L, Yu L, Tu Q, Zhang M, He H, Chen W, Gao J, Yu J, Wu Q, Zhao S (Jan 2001). "Cloning and mapping of human PKIB and PKIG, and comparison of tissue expression patterns of three members of the protein kinase inhibitor family, including PKIA". Biochem J. 349 (Pt 2): 403–7. doi:10.1042/0264-6021:3490403. PMC 1221161. PMID 10880337.
- ^ a b "Entrez Gene: PKIB protein kinase (cAMP-dependent, catalytic) inhibitor beta".
- ^ "UniProt, Q9C010" (jezik: engleski). Pristupljeno 10. 10. 2017.
Dopunska literatura
uredi- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
- Giangrande PH, Hallstrom TC, Tunyaplin C, et al. (2003). "Identification of E-Box Factor TFE3 as a Functional Partner for the E2F3 Transcription Factor". Mol. Cell. Biol. 23 (11): 3707–20. doi:10.1128/MCB.23.11.3707-3720.2003. PMC 155231. PMID 12748276.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Qi ZY, Li Y, Ying K, et al. (2002). "Isolation of novel differentially expressed genes related to human glioma using cDNA microarray and characterizations of two novel full-length genes". J. Neurooncol. 56 (3): 197–208. doi:10.1023/A:1015079705841. PMID 12061725. S2CID 23878825.
- Yu J, Yu L, Chen Z, et al. (2002). "Protein inhibitor of neuronal nitric oxide synthase interacts with protein kinase A inhibitors". Brain Res. Mol. Brain Res. 99 (2): 145–9. doi:10.1016/S0169-328X(02)00104-3. PMID 11978406.
- Scarpetta MA, Uhler MD (1993). "Evidence for two additional isoforms of the endogenous protein kinase inhibitor of cAMP-dependent protein kinase in mouse". J. Biol. Chem. 268 (15): 10927–31. doi:10.1016/S0021-9258(18)82074-9. PMID 7684369.
- Van Patten SM, Ng DC, Th'ng JP, et al. (1991). "Molecular cloning of a rat testis form of the inhibitor protein of cAMP-dependent protein kinase". Proc. Natl. Acad. Sci. U.S.A. 88 (12): 5383–7. doi:10.1073/pnas.88.12.5383. PMC 51877. PMID 2052616.