PIWIL4
Piwi-likim genom utišavanja RNK-posredovani protein 4 je protein koji je kod ljudi kodirtan genom PIWIL4.[5]
Aminokiselinska sekvenca uredi
Dužina polipeptidnog lanca je 852 aminokiseline, a molekulska težina 96.589 Da.[6]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MSGRARVKAR | GIARSPSATE | VGRIQASPLP | RSVDLSNNEA | SSSNGFLGTS | ||||
| RISTNDKYGI | SSGDAGSTFM | ERGVKNKQDF | MDLSICTREK | LAHVRNCKTG | ||||
| SSGIPVKLVT | NLFNLDFPQD | WQLYQYHVTY | IPDLASRRLR | IALLYSHSEL | ||||
| SNKAKAFDGA | ILFLSQKLEE | KVTELSSETQ | RGETIKMTIT | LKRELPSSSP | ||||
| VCIQVFNIIF | RKILKKLSMY | QIGRNFYNPS | EPMEIPQHKL | SLWPGFAISV | ||||
| SYFERKLLFS | ADVSYKVLRN | ETVLEFMTAL | CQRTGLSCFT | QTCEKQLIGL | ||||
| IVLTRYNNRT | YSIDDIDWSV | KPTHTFQKRD | GTEITYVDYY | KQQYDITVSD | ||||
| LNQPMLVSLL | KKKRNDNSEA | QLAHLIPELC | FLTGLTDQAT | SDFQLMKAVA | ||||
| EKTRLSPSGR | QQRLARLVDN | IQRNTNARFE | LETWGLHFGS | QISLTGRIVP | ||||
| SEKILMQDHI | CQPVSAADWS | KDIRTCKILN | AQSLNTWLIL | CSDRTEYVAE | ||||
| SFLNCLRRVA | GSMGFNVDYP | KIIKVQENPA | AFVRAIQQYV | DPDVQLVMCI | ||||
| LPSNQKTYYD | SIKKYLSSDC | PVPSQCVLAR | TLNKQGMMMS | IATKIAMQMT | ||||
| CKLGGELWAV | EIPLKSLMVV | GIDVCKDALS | KDVMVVGCVA | SVNPRITRWF | ||||
| SRCILQRTMT | DVADCLKVFM | TGALNKWYKY | NHDLPARIIV | YRAGVGDGQL | ||||
| KTLIEYEVPQ | LLSSVAESSS | NTSSRLSVIV | VRKKCMPRFF | TEMNRTVQNP | ||||
| PLGTVVDSEA | TRNEWYDFYL | ISQVACRGTV | SPTYYNVIYD | DNGLKPDHMQ | ||||
| RLTFKLCHLY | YNWPGIVSVP | APCQYAHKLT | FLVAQSIHKE | PSLELANHLF | ||||
| YL |
Funkcija uredi
PIWIL4 pripada porodici argonautskih proteina, koji funkcionišu u razvoju i održavanju matičnih ćelija zametne linije (Sasaki et al., 2003 PubMed 12906857]).
Reference uredi
- ^ a b c GRCh38: Ensembl release 89: ENSG00000134627 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036912 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: Piwi like RNA-mediated gene silencing 4". Pristupljeno 11. 2. 2017.
- ^ "UniProt, Q7Z3Z4". Pristupljeno 25. 8. 2021.
Dopunska literatura uredi
- Sugimoto K, Kage H, Aki N, Sano A, Kitagawa H, Nagase T, Yatomi Y, Ohishi N, Takai D (2007). "The induction of H3K9 methylation by PIWIL4 at the p16Ink4a locus". Biochem. Biophys. Res. Commun. 359 (3): 497–502. doi:10.1016/j.bbrc.2007.05.136. PMID 17544373.
- Li L, Yu C, Gao H, Li Y (2010). "Argonaute proteins: potential biomarkers for human colon cancer". BMC Cancer. 10: 38. doi:10.1186/1471-2407-10-38. PMC 2843668. PMID 20146808.
- Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
- Kim JS, Choi YY, Jin G, Kang HG, Choi JE, Jeon HS, Lee WK, Kim DS, Kim CH, Kim YJ, Son JW, Jung TH, Park JY (2010). "Association of a common AGO1 variant with lung cancer risk: a two-stage case-control study". Mol. Carcinog. 49 (10): 913–21. doi:10.1002/mc.20672. PMID 20721975. S2CID 206233924.
- Gu A, Ji G, Shi X, Long Y, Xia Y, Song L, Wang S, Wang X (2010). "Genetic variants in Piwi-interacting RNA pathway genes confer susceptibility to spermatogenic failure in a Chinese population". Hum. Reprod. 25 (12): 2955–61. doi:10.1093/humrep/deq274. PMID 20940137.
- Gu A, Ji G, Shi X, Long Y, Xia Y, Song L, Wang S, Wang X (2010). "Genetic variants in Piwi-interacting RNA pathway genes confer susceptibility to spermatogenic failure in a Chinese population". Hum. Reprod. 25 (12): 2955–61. doi:10.1093/humrep/deq274. PMID 20940137.
- Su C, Ren ZJ, Wang F, Liu M, Li X, Tang H (2012). "PIWIL4 regulates cervical cancer cell line growth and is involved in down-regulating the expression of p14ARF and p53". FEBS Lett. 586 (9): 1356–62. doi:10.1016/j.febslet.2012.03.053. PMID 22483988. S2CID 45962616.
- Greither T, Koser F, Kappler M, Bache M, Lautenschläger C, Göbel S, Holzhausen HJ, Wach S, Würl P, Taubert H (2012). "Expression of human Piwi-like genes is associated with prognosis for soft tissue sarcoma patients". BMC Cancer. 12: 272. doi:10.1186/1471-2407-12-272. PMC 3472179. PMID 22748119.
- Bao J, Zhang Y, Schuster AS, Ortogero N, Nilsson EE, Skinner MK, Yan W (2014). "Conditional inactivation of Miwi2 reveals that MIWI2 is only essential for prospermatogonial development in mice". Cell Death Differ. 21 (5): 783–96. doi:10.1038/cdd.2014.5. PMC 3978311. PMID 24464225.