PFDN1

Prefoldinska podjedinica 1 jest protein koji je kod ljudi kodiran genom PFDN1 sa hromosoma 5.

PFDN1
Identifikatori
Aliasi	PFDN1
Vanjski ID-jevi	OMIM: 604897 MGI: 1914449 HomoloGene: 37644 GeneCards: PFDN1
Lokacija gena (čovjek) Hrom. Hromosom 5 (čovjek) Bend 5q31.3 Početak 140,245,035 bp Kraj 140,303,113 bp
Lokacija gena (miš) Hrom. Hromosom 18 (miš) Bend 18|18 B2 Početak 36,536,729 bp Kraj 36,587,577 bp
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • unfolded protein binding • protein folding chaperone activity Ćelijska komponenta • prefoldin complex • citoplazma Biološki proces • GO:0009373 regulation of transcription, DNA-templated • Savijanje proteina • cytoskeleton organization Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	5201	67199
Ensembl	ENSG00000113068	ENSMUSG00000024346
UniProt	O60925	Q9CWM4 Q9CQF7
RefSeq (mRNK)	NM_002622	NM_026027
RefSeq (bjelančevina)	NP_002613	NP_080303
Lokacija (UCSC)	Chr 5: 140.25 – 140.3 Mb	Chr 18: 36.54 – 36.59 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 122 aminokiseline, а molekulska težina 14.210 Da.

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MAAPVDLELK		KAFTELQAKV		IDTQQKVKLA		DIQIEQLNRT		KKHAHLTDTE
IMTLVDETNM		YEGVGRMFIL		QSKEAIHSQL		LEKQKIAEEK		IKELEQKKSY
LERSVKEAED		NIREMLMARR		AQ

Funkcija

Ovaj gen kodira člana beta podjedinica porodice prefoldina. Kodirani protein jedna je od šest prefoldinskih podjedinica molekuskog šaperonskog kompleksa koji veže i stabilizira novosintetiziranih polipeptida, čime im se omogućuje pravilno savijanje. Kompleks, koji se sastoji od dvije alfa i četiri beta podjedinice, čini dvostruki sklop beta-listova sa šest upredenih zavojnica.

Dopunska literatura

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