Kua-UEV

Kua-UEV
Dostupne strukture
PDB	Pretraga Human UniProta: PDBe RCSB
Spisak PDB ID kodova
	2A4D, 2C2V, 2HLW
Identifikatori
Aliasi	PEDS1-UBE2V1
Vanjski ID-jevi	HomoloGene: 100008 GeneCards: PEDS1-UBE2V1
Lokacija gena (čovjek)
Hrom.	Hromosom 20 (čovjek)
Kraj	50,153,637 bp
Ontologija gena
Molekularna funkcija	• ubiquitin protein ligase binding; • GO:1904264, GO:1904822, GO:0090622, GO:0090302 ubiquitin protein ligase activity; • GO:0001948, GO:0016582 vezivanje za proteine; • ubiquitin conjugating enzyme activity;
Ćelijska komponenta	• citoplazma; • integral component of membrane; • endoplasmic reticulum membrane; • membrana; • Endoplazmatski retikulum; • citosol; • ubiquitin conjugating enzyme complex; • UBC13-UEV1A complex; • kompleks ubikvitin-ligaze; • Egzosom; • jedro; • nukleoplazma; • GO:0009327 makromolekulani kompleks;
Biološki proces	• protein ubiquitination; • protein polyubiquitination; • Fc-epsilon receptor signaling pathway; • protein K63-linked ubiquitination; • nucleotide-binding oligomerization domain containing signaling pathway; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • stimulatory C-type lectin receptor signaling pathway; • regulation of DNA repair; • GO:0009373 regulation of transcription, DNA-templated; • T cell receptor signaling pathway; • Ćelijska diferencijacija; • Postreplikacijska reparacija; • positive regulation of I-kappaB kinase/NF-kappaB signaling; • JNK cascade; • positive regulation of NF-kappaB transcription factor activity; • interleukin-1-mediated signaling pathway;
	Izvori:Amigo / QuickGO
Ortolozi
	387522
	n/a
	ENSG00000124208
	n/a
	Q13404
	n/a
	NM_003349; NM_199203
	n/a
NP_001155977; NP_954580; NP_954673; NP_001027459; NP_001244322;
	NP_001244323; NP_001244324; NP_001244325; NP_001244326; NP_001244327; NP_001244328; NP_001269504; NP_001269505; NP_001269506; NP_001269507; NP_001269508; NP_001269509; NP_068823; NP_071887; NP_954595; NP_954673
	n/a
	Wikipodaci
Pogledaj/uredi – čovjek

Varijanta 1 ubikvitin E2-konjugirajućeg enzima, znana i kao Kua-UEV, jest ljudski gen.^[3]

Kua-UEV iRNK je rijedak, ali prirodno kotranskribiran proizvod susjednih Kua i UBE2V1 gena.^[4] Proteinske varijante enzima E2 koji konjugiraju ubikvitin čine posebnu potporodicu unutar porodice proteina E2. Imaju sličnost sekvenci s drugim enzimima koji konjuguju s ubikvitinom, ali im nedostaje konzervirani ostatak cisteina, koji je presudan za katalitsku aktivnost E2. Opisana su dva alternativna transkripta koji kodiraju različite izoforme. Proteini proizvedeni ovim transkriptima imaju domene UEV1 B, ali su proteini lokalizirani u citoplazmi, a ne u jedru. Značaj ovih kotranskribiranih iRNK i funkcija njihovih proteinskih proizvoda još nisu utvrđeni.^[3]

Molekulske funkcije

vezanje proteina ligabe ubikvitina
GO: 1904264, GO: 1904822, GO: 0090622, GO: 0090302 aktivnost ligaze proteina ubikvitina
GO: 0001948 vezanje za proteine
aktivnost enzima koji konjugira ubikvitin

Ćelijska komponenta

citoplazma
integralna komponenta membrane
membrana endoplazmatskog retikuluma
ćelijska membrana
endoplazmatski retikulum
citosol
kompleks enzima za konjugaciju ubikvitina
UBC13-UEV1A kompleks
kompleks ubikvitin-ligaze
vanćelijski egzosom
jedro
nukleoplazma
kompleks koji sadrži proteine

Biološki procesi

ubikvitinacija proteina
poliubikvitinacija proteina
put signalizacije Fc-epsilon receptora
K63-vezana ubikvitinacija proteina
domen oligomerizacije koja veže nukleotide i sadrži signalni put
pozitivna regulacija transkripcije, sa predloškom DNK
stimulativni signalni put lektinskih receptora tipa C
regulacija popravljanja DNK
regulacija transkripcije, sa predloškom DNK
signalni put receptora T-ćelija
ćelijska diferencijacija
Postreplikacvijski popravak DNK
pozitivna regulacija signalizacije I-kappaB kinaze/NF-kappaB
aktiviranje djelovanja MAPK
JNK kaskada
pozitivna regulacija aktivnosti NF-kappaB faktora transkripcije
signalni put koji posreduje interleukin-1

Izvori: Amigo/QuickGO

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000124208 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: Kua-UEV ubiquitin-conjugating enzyme E2 variant 1".
^ Thomson TM, Lozano JJ, Loukili N, Carrió R, Serras F, Cormand B, et al. (novembar 2000). "Fusion of the human gene for the polyubiquitination coeffector UEV1 with Kua, a newly identified gene". Genome Research. 10 (11): 1743–56. doi:10.1101/gr.gr-1405r. PMC 310942. PMID 11076860.

Dopunska literatura

Long M (novembar 2000). "A new function evolved from gene fusion". Genome Research. 10 (11): 1655–7. doi:10.1101/gr.165700. PMID 11076848.
Bonaldo MF, Lennon G, Soares MB (septembar 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Rothofsky ML, Lin SL (august 1997). "CROC-1 encodes a protein which mediates transcriptional activation of the human FOS promoter". Gene. 195 (2): 141–9. doi:10.1016/S0378-1119(97)00097-8. PMID 9305758.
Sancho E, Vilá MR, Sánchez-Pulido L, Lozano JJ, Paciucci R, Nadal M, et al. (januar 1998). "Role of UEV-1, an inactive variant of the E2 ubiquitin-conjugating enzymes, in in vitro differentiation and cell cycle behavior of HT-29-M6 intestinal mucosecretory cells". Molecular and Cellular Biology. 18 (1): 576–89. doi:10.1128/mcb.18.1.576. PMC 121525. PMID 9418904.
Xiao W, Lin SL, Broomfield S, Chow BL, Wei YF (septembar 1998). "The products of the yeast MMS2 and two human homologs (hMMS2 and CROC-1) define a structurally and functionally conserved Ubc-like protein family". Nucleic Acids Research. 26 (17): 3908–14. doi:10.1093/nar/26.17.3908. PMC 147796. PMID 9705497.
Ma L, Broomfield S, Lavery C, Lin SL, Xiao W, Bacchetti S (septembar 1998). "Up-regulation of CIR1/CROC1 expression upon cell immortalization and in tumor-derived human cell lines". Oncogene. 17 (10): 1321–6. doi:10.1038/sj.onc.1202058. PMID 9771976.
Hofmann RM, Pickart CM (mart 1999). "Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair". Cell. 96 (5): 645–53. doi:10.1016/S0092-8674(00)80575-9. PMID 10089880.
Deng L, Wang C, Spencer E, Yang L, Braun A, You J, et al. (oktobar 2000). "Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain". Cell. 103 (2): 351–61. doi:10.1016/S0092-8674(00)00126-4. PMID 11057907.
Thomson TM, Lozano JJ, Loukili N, Carrió R, Serras F, Cormand B, et al. (novembar 2000). "Fusion of the human gene for the polyubiquitination coeffector UEV1 with Kua, a newly identified gene". Genome Research. 10 (11): 1743–56. doi:10.1101/gr.GR-1405R. PMC 310942. PMID 11076860.
Dias DC, Dolios G, Wang R, Pan ZQ (decembar 2002). "CUL7: A DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex". Proceedings of the National Academy of Sciences of the United States of America. 99 (26): 16601–6. doi:10.1073/pnas.252646399. PMC 139190. PMID 12481031.
Guo D, Han J, Adam BL, Colburn NH, Wang MH, Dong Z, et al. (decembar 2005). "Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress". Biochemical and Biophysical Research Communications. 337 (4): 1308–18. doi:10.1016/j.bbrc.2005.09.191. PMID 16236267.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000124208 - Ensembl, maj 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-3] "Entrez Gene: Kua-UEV ubiquitin-conjugating enzyme E2 variant 1".

[4] Thomson TM, Lozano JJ, Loukili N, Carrió R, Serras F, Cormand B, et al. (novembar 2000). "Fusion of the human gene for the polyubiquitination coeffector UEV1 with Kua, a newly identified gene". Genome Research. 10 (11): 1743–56. doi:10.1101/gr.gr-1405r. PMC 310942. PMID 11076860.

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