PRIC285

(Preusmjereno sa PDIP-1)

Interaktivni kompleks receptora A aktiviranog peroksisomskim proliferatorom 285 je ljudski gen.[5]

PRIC285
Identifikatori
AliasiHELZ2
Vanjski ID-jeviOMIM: 611265 MGI: 2385169 HomoloGene: 14118 GeneCards: HELZ2
Lokacija gena (čovjek)
Hromosom 20 (čovjek)
Hrom.Hromosom 20 (čovjek)[1]
Hromosom 20 (čovjek)
Genomska lokacija za PRIC285
Genomska lokacija za PRIC285
Bend20q13.33Početak63,558,086 bp[1]
Kraj63,574,239 bp[1]
Lokacija gena (miš)
Hromosom 2 (miš)
Hrom.Hromosom 2 (miš)[2]
Hromosom 2 (miš)
Genomska lokacija za PRIC285
Genomska lokacija za PRIC285
Bend2|2 H4Početak180,869,408 bp[2]
Kraj180,883,820 bp[2]
Ontologija gena
Molekularna funkcija vezivanje sa DNK
nucleotide binding
GO:0001948, GO:0016582 vezivanje za proteine
ATP binding
hydrolase activity
GO:0008026 helicase activity
nuclear receptor coactivator activity
vezivanje iona metala
vezivanje sa RNK
ribonuclease activity
Ćelijska komponenta membrana
jedro
nukleoplazma
citoplazma
Biološki proces GO:0009373 regulation of transcription, DNA-templated
transcription, DNA-templated
GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II
regulation of lipid metabolic process
Nonsens-posredovano propadanje iRNK
RNA phosphodiester bond hydrolysis
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_001037335
NM_033405

NM_183162

RefSeq (bjelančevina)

NP_001032412
NP_208384

NP_898985

Lokacija (UCSC)Chr 20: 63.56 – 63.57 MbChr 2: 180.87 – 180.88 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Protein kojega kodira ovaj gen je jedarni transkripcijski koaktivator za receptor alfa aktiviran proliferatorom peroksisoma. Kodirani protein sadrži cinkov prst i helikazu koja je čini se dijelom kompleksa interakcije receptora alfa koji aktivira proliferator peroksisoma. Ovaj gen je član porodice gena DNK2/NAM7 helikaza. Za ovaj gen pronađene su alternativno prerađene varijante transkripta koje kodiraju različite izoforme.[5]

Aminokiselinska sekvenca proteina

uredi
Simboli
1020304050
MAVWEAEQLGGLQRGDLLTPPAPDGDGRTAPLGQPPGAQLYCPACLVTCH
SQEAFENHCASSEHAQMVAFDQALPWEHRSPPPGLSKFELCPKPDLCEYG
DACTKAHSAQELQEWVRRTQAVELRGQAAWQDGLVPYQERLLAEYQRSSS
EVLVLAETLDGVRVTCNQPLMYQAQERKTQYSWTFAVHSEEPLLHVALLK
QEPGADFSLVAPGLPPGRLYARGERFRVPSSTADFQVGVRVQAASFGTFE
QWVVFDFGRRPVLLQKLGLQLGQGRRPGPCRNLALGHPEEMERWHTGNRH
VVPGVERTAEQTALMAKYKGPALALEFNRSSVASGPISPTNYRQRMHQFL
YEEEAAQQQLVAKLTLRGQVFLKTALQTPALNMLFAPPGALYAEVPVPSS
LMPDTDQGFLLGRAVSTALVAPVPAPDNTVFEVRLERRASSEQALWLLLP
ARCCLALGLQPEARLVLEVQFQIDPMTFRLWHQAVDTLPEEQLVVPDLPT
CALPRPWSVPPLRRGNRKQELAVALIAGWGPGDGRRVPPLLIYGPFGTGK
TYTLAMASLEVIRRPETKVLICTHTNSAADIYIREYFHSHVSGGHPEATP
LRVMYTDRPLSQTDPVTLQYCCLTDDRQAFRPPTRAELARHRVVVTTTSQ
ARELRVPVGFFSHILIDEAAQMLECEALTPLAYASHGTRLVLAGDHMQVT
PRLFSVARARAAEHTLLHRLFLCYQQETHEVARQSRLVFHENYRCTDAIV
SFISRHFYVAKGNPIHARGKVPPHPRHYPLMFCHVAGSPDRDMSMASWLN
LAEIAQVVEKVQEAYNTWPSCWGGREQRCICVVSHGAQVSALRQELRRRD
LGQVSVGSFEILPGRQFRVVVLSTVHTCQSLLSPGALAPEFFTDARVLNT
VLTRAQSQLVVVGDAVALCSFGACGKLWESFIRECVERHSVCPEGLSMEQ
VEQGVAQRRRWPPRGTQAGAAGNWEAAPEPVGDLAEEQAAVVTAMVKAEP
GDEALSPASRDITATTAQTEAAAAPAGDAVKEDVVPGACAAGAAAAAGVE
STEAEDAEADFWPWDGELNADDAILRELLDESQKVMVTVGEDGLLDTVAR
PESLQQARLYENLPPAALRKLLHAEPERYRHCSFVPETFERASAIPLDDA
SSGPIQVRGRLDCGMAFAGDEVLVQLLSGDKAPEGRLRGRVLGVLKRKRH
ELAFVCRMDTWDPRIMVPINGSVTKIFVAELKDPSQVPIYSLRKGRLQRV
GLERLTAEARHSRLFWVQIVLWRQGFYYPLGIVREVLPEASTWEQGLRIL
GLEYSLRVPPSDQATITKVLQKYHTELGRVAGRREDCRAFLTFTVDPQGA
CNLDDALSVRDLGPRCEVAVHITDVASFVPRDGVLDVEARRQGAAFYAPG
REPVPMLPASLCQDVLSLLPGRDRLAISLFLTMEKASGQLKSLRFAPSVV
QSDRQLSYEEAEEVIRQHPGAGRELPARLDSVDACVVAACYFSRLLRRHR
LRSDCFYEQPDEDGTLGFRAAHIMVKEYMIQFNRLVAEFLVGSECTRTVT
PLRWQPAPRSQQLKALCEKHGDRVPLSLHLGHHLHGGGGSPPDTRLHLLA
SLWKQVQFAARTQDYEQMVDLVTTDDMHPFLAPAGRDLRKALERSAFGRC
ARGHQQQGGHYSLQVDWYTWATSPIRRYLDVVLQRQILLALGHGGSAYSA
RDIDGLCQAFSLQHALAQSYQRRARSLHLAVQLKAQPLDKLGFVVDVEAG
SRCFRLLFPSNRETLPDPCPVPYGSLQLAEHPHALAGRPGLRLLWRRRVY
SAQGSSPPLPLPGTVPDPHTLAVETALWKQLLELVELQRWPEAAALIQEK
GEASQRRELVQVQRSHCGHFLEVARELGSGDTLQVQLGTSLQHGFLVPSP
QLWTVAPGFSLCLEHVERPGDCFSGRVYRAPRDRYRDVDEYACVWEPFCA
LESATGAVAENDSVTLQHLSVSWEASRTPQGQLQGAFRLEAAFLEENCAD
INFSCCYLCIRLEGLPAPTASPRPGPSSLGPGLNVDPGTYTWVAHGQTQD
WDQERRADRQEAPRRVHLFVHHMGMEKVPEEVLRPGTLFTVELLPKQLPD
LRKEEAVRGLEEASPLVTSIALGRPVPQPLCRVIPSRFLERQTYNIPGGR
HKLNPSQNVAVREALEKPFTVIQGPPGTGKTIVGLHIVFWFHKSNQEQVQ
PGGPPRGEKRLGGPCILYCGPSNKSVDVLAGLLLRRMELKPLRVYSEQAE
ASEFPVPRVGSRKLLRKSPREGRPNQSLRSITLHHRIRQAPNPYSSEIKA
FDTRLQRGELFSREDLVWYKKVLWEARKFELDRHEVILCTCSCAASASLK
ILDVRQILVDEAGMATEPETLIPLVQFPQAEKVVLLGDHKQLRPVVKNER
LQNLGLDRSLFERYHEDAHMLDTQYRMHEGICAFPSVAFYKSKLKTWQGL
RRPPSVLGHAGKESCPVIFGHVQGHERSLLVSTDEGNENSKANLEEVAEV
VRITKQLTLGRTVEPQDIAVLTPYNAQASEISKALRREGIAGVAVSSITK
SQGSEWRYVLVSTVRTCAKSDLDQRPTKSWLKKFLGFVVDPNQVNVAVTR
AQEGLCLIGDHLLLRCCPLWRSLLDFCEAQQTLVPAGQVRVCRRPTMPS

Reference

uredi
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000130589 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027580 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: PRIC285 peroxisomal proliferator-activated receptor A interacting complex 285".

Dopunska literatura

uredi