PARD3B

PARD3B
Identifikatori
Aliasi	PARD3B
Vanjski ID-jevi	MGI: 1919301 HomoloGene: 35389 GeneCards: PARD3B
Lokacija gena (čovjek)
Hrom.	Hromosom 2 (čovjek)
Kraj	205,620,162 bp
Lokacija gena (miš)
Hrom.	Hromosom 1 (miš)
Kraj	62,681,443 bp
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine; • phosphatidylinositol binding;
Ćelijska komponenta	• membrana; • Endomembranski sistem; • bicellular tight junction; • međućelijske veze; • nukleoplazma; • nuclear body; • GO:0009327 makromolekulani kompleks; • citoplazma; • adherens junction; • cell cortex; • apical plasma membrane; • apical junction complex;
Biološki proces	• Ćelijska dioba; • ćelijski ciklus; • microtubule cytoskeleton organization; • Ćelijska adhezija; • GO:0034613 protein localization; • establishment of cell polarity; • establishment or maintenance of epithelial cell apical/basal polarity; • establishment of centrosome localization;
	Izvori:Amigo / QuickGO
Ortolozi
	117583
	72823
	ENSG00000116117
	ENSMUSG00000052062
	Q8TEW8
	Q9CSB4
	NM_001302769; NM_057177; NM_152526; NM_205863
	NM_001081050
	NP_001289698; NP_476518; NP_689739; NP_995585
	NP_001074519
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Homolog B parceliranog defetinog proteina 3 jest protein koji je kod ljudi kodiran genom PARD3B sa hromosoma 2.^[5]^[6]^[7]

Amiokiselininska sekvenca

Dužina polipeptidnog lanca je 1 205 aminokiselina, a molekulska težina 132.494 Da.^[8]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MKVTVCFGRT	GIVVPCKEGQ	LRVGELTQQA	LQRYLKTREK	GPGYWVKIHH
LEYTDGGILD	PDDVLADVVE	DKDKLIAVFE	EQEPLHKIES	PSGNPADRQS
PDAFETEVAA	QLAAFKPIGG	EIEVTPSALK	LGTPLLVRRS	SDPVPGPPAD
TQPSASHPGG	QSLKLVVPDS	TQNLEDREVL	NGVQTELLTS	PRTKDTLSDM
TRTVEISGEG	GPLGIHVVPF	FSSLSGRILG	LFIRGIEDNS	RSKREGLFHE
NECIVKINNV	DLVDKTFAQA	QDVFRQAMKS	PSVLLHVLPP	QNREQYEKSV
IGSLNIFGNN	DGVLKTKVPP	PVHGKSGLKT	ANLTGTDSPE	TDASASLQQN
KSPRVPRLGG	KPSSPSLSPL	MGFGSNKNAK	KIKIDLKKGP	EGLGFTVVTR
DSSIHGPGPI	FVKNILPKGA	AIKDGRLQSG	DRILEVNGRD	VTGRTQEELV
AMLRSTKQGE	TASLVIARQE	GHFLPRELKG	EPDCCALSLE	TSEQLTFEIP
LNDSGSAGLG	VSLKGNKSRE	TGTDLGIFIK	SIIHGGAAFK	DGRLRMNDQL
IAVNGESLLG	KSNHEAMETL	RRSMSMEGNI	RGMIQLVILR	RPERPMEDPA
ECGAFSKPCF	ENCQNAVTTS	RRNDNSILHP	LGTCSPQDKQ	KGLLLPNDGW
AESEVPPSPT	PHSALGLGLE	DYSHSSGVDS	AVYFPDQHIN	FRSVTPARQP
ESINLKASKS	MDLVPDESKV	HSLAGQKSES	PSKDFGPTLG	LKKSSSLESL
QTAVAEVRKN	DLPFHRPRPH	MVRGRGCNES	FRAAIDKSYD	GPEEIEADGL
SDKSSHSGQG	ALNCESAPQG	NSELEDMENK	ARKVKKTKEK	EKKKEKGKLK
VKEKKRKEEN	EDPERKIKKK	GFGAMLRFGK	KKEDKGGKAE	QKGTLKHGGL
REEELEKMKE	ERERIGAKHQ	ELREKQARGL	LDYATGAIGS	VYDMDDDEMD
PNYARVNHFR	EPCTSANVFR	SPSPPRAGPF	GYPRDGHPLS	PERDHLEGLY
AKVNKPYHPL	VPADSGRPTG	GSTDRIQKLR	KEYYQARREG	FPLYEDDEGR
ARPSEYDLLW	VPGRGPDGNA	HNLRFEGMER	QYASLPRGGP	ADPVDYLPAA
PRGLYKEREL	PYYPGAHPMH	PPKGSYPRPT	ELRVADLRYP	QHYPPPPAPQ
HKGPFRQDVP	PSPPQHQRMP	AYQETGRPGP	RGGSPDQYPY	RTQDSRQKNP
MTAAV

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000116117 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000052062 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hadano S, Hand CK, Osuga H, Yanagisawa Y, Otomo A, Devon RS, Miyamoto N, Showguchi-Miyata J, Okada Y, Singaraja R, Figlewicz DA, Kwiatkowski T, Hosler BA, Sagie T, Skaug J, Nasir J, Brown RH Jr, Scherer SW, Rouleau GA, Hayden MR, Ikeda JE (Oct 2001). "A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2". Nat Genet. 29 (2): 166–73. doi:10.1038/ng1001-166. PMID 11586298. S2CID 52828189.
^ Kohjima M, Noda Y, Takeya R, Saito N, Takeuchi K, Sumimoto H (Dec 2002). "PAR3beta, a novel homologue of the cell polarity protein PAR3, localizes to tight junctions". Biochem Biophys Res Commun. 299 (4): 641–6. doi:10.1016/S0006-291X(02)02698-0. PMID 12459187.
^ "Entrez Gene: PARD3B par-3 partitioning defective 3 homolog B (C. elegans)".
^ "UniProt, Q8TEW8" (jezik: eng). Pristupljeno 18. 11. 2021.CS1 održavanje: nepoznati jezik (link)

Dopunska literatura

Izaki T, Kamakura S, Kohjima M, Sumimoto H (2006). "Two forms of human Inscuteable-related protein that links Par3 to the Pins homologues LGN and AGS3". Biochem. Biophys. Res. Commun. 341 (4): 1001–6. doi:10.1016/j.bbrc.2006.01.050. PMID 16458856.
Benzinger A, Muster N, Koch HB, et al. (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Mol. Cell. Proteomics. 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.
Izaki T, Kamakura S, Kohjima M, Sumimoto H (2005). "Phosphorylation-dependent binding of 14-3-3 to Par3beta, a human Par3-related cell polarity protein". Biochem. Biophys. Res. Commun. 329 (1): 211–8. doi:10.1016/j.bbrc.2005.01.115. PMID 15721295.
Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Warner DR, Pisano MM, Roberts EA, Greene RM (2003). "Identification of three novel Smad binding proteins involved in cell polarity". FEBS Lett. 539 (1–3): 167–73. doi:10.1016/S0014-5793(03)00155-8. PMID 12650946. S2CID 7429554.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gao L, Macara IG, Joberty G (2003). "Multiple splice variants of Par3 and of a novel related gene, Par3L, produce proteins with different binding properties". Gene. 294 (1–2): 99–107. doi:10.1016/S0378-1119(02)00681-9. PMID 12234671.

Vanjski linkovi

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000116117 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000052062 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11586298-5] Hadano S, Hand CK, Osuga H, Yanagisawa Y, Otomo A, Devon RS, Miyamoto N, Showguchi-Miyata J, Okada Y, Singaraja R, Figlewicz DA, Kwiatkowski T, Hosler BA, Sagie T, Skaug J, Nasir J, Brown RH Jr, Scherer SW, Rouleau GA, Hayden MR, Ikeda JE (Oct 2001). "A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2". Nat Genet. 29 (2): 166–73. doi:10.1038/ng1001-166. PMID 11586298. S2CID 52828189.

[pmid12459187-6] Kohjima M, Noda Y, Takeya R, Saito N, Takeuchi K, Sumimoto H (Dec 2002). "PAR3beta, a novel homologue of the cell polarity protein PAR3, localizes to tight junctions". Biochem Biophys Res Commun. 299 (4): 641–6. doi:10.1016/S0006-291X(02)02698-0. PMID 12459187.

[entrez-7] "Entrez Gene: PARD3B par-3 partitioning defective 3 homolog B (C. elegans)".

[UniProt-8] "UniProt, Q8TEW8" (jezik: eng). Pristupljeno 18. 11. 2021.CS1 održavanje: nepoznati jezik (link)

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