NUPL1

Nukleoporin p58/p45 je protein koji je kod ljudi kodiran genom NUPL1.

NUPL1
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 4JO7, 4JO9, 4JQ5, 5IJN, 5IJO
Identifikatori
Aliasi	NUP58
Vanjski ID-jevi	OMIM: 607615 MGI: 1919094 HomoloGene: 40924 GeneCards: NUP58
Lokacija gena (čovjek) Hrom. Hromosom 13 (čovjek) Bend 13q12.13 Početak 25,301,152 bp Kraj 25,365,390 bp
Lokacija gena (miš) Hrom. Hromosom 14 (miš) Bend 14|14 D1 Početak 60,442,731 bp Kraj 60,488,956 bp
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • GO:0001948, GO:0016582 vezivanje za proteine • nuclear localization sequence binding • GO:0005487 structural constituent of nuclear pore Ćelijska komponenta • Jedarna membrana • nuclear envelope • membrana • jedro • jedrova pora • GO:0009327 makromolekulani kompleks • host cell Biološki proces • mRNA transport • protein heterotetramerization • protein heterooligomerization • nucleocytoplasmic transport • regulation of protein import into nucleus • protein transport • GO:0022415 viral process • protein homooligomerization • mRNA export from nucleus • protein import into nucleus • protein heterotrimerization • regulation of glycolytic process • tRNA export from nucleus • protein sumoylation • viral transcription • GO:1905616 regulation of gene silencing by miRNA • GO:0046795 intracellular transport of virus • regulation of cellular response to heat Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	9818	71844
Ensembl	ENSG00000139496	ENSMUSG00000114797
UniProt	Q9BVL2	Q8R332
RefSeq (mRNK)	NM_001008564 NM_001008565 NM_014089 NM_014778	NM_170591 NM_001362439 NM_001362440
RefSeq (bjelančevina)	NP_001008564 NP_054808	NP_733479 NP_001349368 NP_001349369
Lokacija (UCSC)	Chr 13: 25.3 – 25.37 Mb	Chr 14: 60.44 – 60.49 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Ovaj gen kodira člana porodice nukleoporina koji dijeli 87% identiteta sekvence s nukleoporinom p58 pacova. Protein je lokaliziran na jedarnom rubu i sastavni je dio kompleksa jedarnih pora (NPC).

Sve molekule koji ulaze ili izlaze iz jedra difundiraju ili se aktivno transportiraju pomoću NPC -a. Okarakterizirane su alternativne transkripcijske varijante, koje kodiraju različite izoforme.

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 599 aminokiselina, a molekulska težina 60.897 Da..

10		20		30		40		50
MSTGFSFGSG		TLGSTTVAAG		GTSTGGVFSF		GTGASSNPSV		GLNFGNLGST
STPATTSAPS		SGFGTGLFGS		KPATGFTLGG		TNTGIATTIT		TGLTLGTPAT
TSAATTGFSL		GFNKPAASAT		PFALPITSTS		ASGLTLSSAL		TSTPAASTGF
TLNNLGGTTA		TTTTASTGLS		LGGALAGLGG		SLFQSTNTGT		SGLGQNALGL
TLGTTAATST		AGNEGLGGID		FSSSSDKKSD		KTGTRPEDSK		ALKDENLPPV
ICQDVENLQK		FVKEQKQVQE		EISRMSSKAM		LKVQEDIKAL		KQLLSLAANG
IQRNTLNIDK		LKIETAQELK		NAEIALRTQK		TPPGLQHEYA		APADYFRILV
QQFEVQLQQY		RQQIEELENH		LATQANNSHI		TPQDLSMAMQ		KIYQTFVALA
AQLQSIHENV		KVLKEQYLGY		RKMFLGDAVD		VFETRRAEAK		KWQNTPRVTT
GPTPFSTMPN		AAAVAMAATL		TQQQQPATGP		QPSLGVSFGT		PFGSGIGTGL
QSSGLGSSNL		GGFGTSSGFG		CSTTGASTFG		FGTTNKPSGS		LSAGFGSSST
SGFNFSNPGI		TASAGLTFGV		SNPASAGFGT		GGQLLQLKKP		PAGNKRGKR

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

Dopunska literatura

• Buss F, Stewart M (1995). "Macromolecular interactions in the nucleoporin p62 complex of rat nuclear pores: binding of nucleoporin p54 to the rod domain of p62". J. Cell Biol. 128 (3): 251–61. doi:10.1083/jcb.128.3.251. PMC 2120351. PMID 7531196.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Ben-Efraim I, Gerace L (2001). "Gradient of Increasing Affinity of Importin β for Nucleoporins along the Pathway of Nuclear Import". J. Cell Biol. 152 (2): 411–7. doi:10.1083/jcb.152.2.411. PMC 2199621. PMID 11266456.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.