Jedarni receptor-vezujući protein jest protein koji je kod ljudi kodiran genom NRBP1 sa hromosoma 2.[5][6][7]

NRBP1
Identifikatori
AliasiNRBP1
Vanjski ID-jeviOMIM: 606010 MGI: 2183436 HomoloGene: 8373 GeneCards: NRBP1
Lokacija gena (čovjek)
Hromosom 2 (čovjek)
Hrom.Hromosom 2 (čovjek)[1]
Hromosom 2 (čovjek)
Genomska lokacija za NRBP1
Genomska lokacija za NRBP1
Bend2p23.3Početak27,427,790 bp[1]
Kraj27,442,259 bp[1]
Lokacija gena (miš)
Hromosom 5 (miš)
Hrom.Hromosom 5 (miš)[2]
Hromosom 5 (miš)
Genomska lokacija za NRBP1
Genomska lokacija za NRBP1
Bend5|5 B1Početak31,398,208 bp[2]
Kraj31,408,910 bp[2]
Obrazac RNK ekspresije
Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija protein kinase activity
GO:0001948, GO:0016582 vezivanje za proteine
ATP binding
protein serine/threonine kinase activity
protein homodimerization activity
Ćelijska komponenta citoplazma
projekcija ćelije
cell cortex
membrana
Endomembranski sistem
lamellipodium
nukleoplazma
citosol
Biološki proces endoplasmic reticulum to Golgi vesicle-mediated transport
transcription initiation from RNA polymerase II promoter
GO:0007243 intracellular signal transduction
protein phosphorylation
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)
NM_013392
NM_001321357
NM_001321358
NM_001321359
NM_001321361

NM_001321362
NM_001321363

NM_147201
NM_001347326

RefSeq (bjelančevina)
NP_001308286
NP_001308287
NP_001308288
NP_001308290
NP_001308291

NP_001308292
NP_037524

NP_001334255
NP_671734

Lokacija (UCSC)Chr 2: 27.43 – 27.44 MbChr 5: 31.4 – 31.41 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Amiokiselininska sekvenca

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Dužina polipeptidnog lanca je 535 aminokiselina, a molkekulska iežina 59.845 Da.[8]

1020304050
MSEGESQTVLSSGSDPKVESSSSAPGLTSVSPPVTSTTSAASPEEEEESE
DESEILEESPCGRWQKRREEVNQRNVPGIDSAYLAMDTEEGVEVVWNEVQ
FSERKNYKLQEEKVRAVFDNLIQLEHLNIVKFHKYWADIKENKARVIFIT
EYMSSGSLKQFLKKTKKNHKTMNEKAWKRWCTQILSALSYLHSCDPPIIH
GNLTCDTIFIQHNGLIKIGSVAPDTINNHVKTCREEQKNLHFFAPEYGEV
TNVTTAVDIYSFGMCALEMAVLEIQGNGESSYVPQEAISSAIQLLEDPLQ
REFIQKCLQSEPARRPTARELLFHPALFEVPSLKLLAAHCIVGHQHMIPE
NALEEITKNMDTSAVLAEIPAGPGREPVQTLYSQSPALELDKFLEDVRNG
IYPLTAFGLPRPQQPQQEEVTSPVVPPSVKTPTPEPAEVETRKVVLMQCN
IESVEEGVKHHLTLLLKLEDKLNRHLSCDLMPNENIPELAAELVQLGFIS
EADQSRLTSLLEETLNKFNFARNSTLNSAAVTVSS

Reference

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000115216 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029148 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Hooper JD, Baker E, Ogbourne SM, Sutherland GR, Antalis TM (Jul 2000). "Cloning of the cDNA and localization of the gene encoding human NRBP, a ubiquitously expressed, multidomain putative adapter protein". Genomics. 66 (1): 113–8. doi:10.1006/geno.2000.6167. PMID 10843813.
  6. ^ De Langhe S, Haataja L, Senadheera D, Groffen J, Heisterkamp N (Apr 2002). "Interaction of the small GTPase Rac3 with NRBP, a protein with a kinase-homology domain". Int J Mol Med. 9 (5): 451–9. doi:10.3892/ijmm.9.5.451. PMID 11956649.
  7. ^ "Entrez Gene: NRBP1 nuclear receptor binding protein 1".
  8. ^ "UniProt, Q9UHY1" (jezik: engleski). Pristupljeno 13. 11. 2021.

Dopunska literatura

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