NINJ1

NINJ1
Identifikatori
Aliasi	NINJ1
Vanjski ID-jevi	OMIM: 602062 MGI: 1196617 HomoloGene: 88815 GeneCards: NINJ1
Lokacija gena (čovjek)
Hrom.	Hromosom 9 (čovjek)
Kraj	93,134,251 bp
Lokacija gena (miš)
Hrom.	Hromosom 13 (miš)
Kraj	49,349,720 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine;
Ćelijska komponenta	• integral component of membrane; • membrana;
Biološki proces	• hyaloid vascular plexus regression; • Ćelijska adhezija; • nervous system development; • tissue regeneration; • positive regulation of cell-matrix adhesion; • Piroptoza; • Ćelijska smrt;
	Izvori:Amigo / QuickGO
Ortolozi
	4814
	18081
	ENSG00000131669
	ENSMUSG00000037966
	Q92982
	O70131
	NM_004148
	NM_013610
	NP_004139
	NP_038638
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Ninjurin-1 je protein koji je kod ljudi kodiran genom NINJ1.^[5]^[6]

Aminokiselinska sekvenca uredi

Dužina polipeptidnog lanca je 152 aminokiseline, а molekulska težina 16.345 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MDSGTEEYEL	NGGLPPGTPG	SPDASPARWG	WRHGPINVNH	YASKKSAAES
MLDIALLMAN	ASQLKAVVEQ	GPSFAFYVPL	VVLISISLVL	QIGVGVLLIF
LVKYDLNNPA	KHAKLDFLNN	LATGLVFIIV	VVNIFITAFG	VQKPLMDMAP
QQ

Reference uredi

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000131669 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000037966 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Araki T, Milbrandt J (Oct 1996). "Ninjurin, a novel adhesion molecule, is induced by nerve injury and promotes axonal growth". Neuron. 17 (2): 353–61. doi:10.1016/S0896-6273(00)80166-X. PMID 8780658. S2CID 12471778.
^ "Entrez Gene: NINJ1 ninjurin 1".
^ "UniProt, Q92982". Pristupljeno 10. 9. 2021.

Dopunska literatura uredi

Guimarães PE, Fridman C, Gregório SP, et al. (2007). "WITHDRAWN: Association between polymorphisms in genes of inflammatory response and axonal repair with spinal cord injury". Spinal Cord. doi:10.1038/sj.sc.3102122. PMID 17893696.
Cardoso CC, Martinez AN, Guimarães PE, et al. (2007). "Ninjurin 1 asp110ala single nucleotide polymorphism is associated with protection in leprosy nerve damage". J. Neuroimmunol. 190 (1–2): 131–8. doi:10.1016/j.jneuroim.2007.07.015. PMID 17825431. S2CID 20637695.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Toyama T, Sasaki Y, Horimoto M, et al. (2005). "Ninjurin1 increases p21 expression and induces cellular senescence in human hepatoma cells". J. Hepatol. 41 (4): 637–43. doi:10.1016/j.jhep.2004.06.027. PMID 15464245.
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Chadwick BP, Heath SK, Williamson J, et al. (1998). "The human homologue of the ninjurin gene maps to the candidate region of hereditary sensory neuropathy type I (HSNI)". Genomics. 47 (1): 58–63. doi:10.1006/geno.1997.5084. PMID 9465296.
Araki T, Zimonjic DB, Popescu NC, Milbrandt J (1997). "Mechanism of homophilic binding mediated by ninjurin, a novel widely expressed adhesion molecule". J. Biol. Chem. 272 (34): 21373–80. doi:10.1074/jbc.272.34.21373. PMID 9261151.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000131669 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000037966 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8780658-5] Araki T, Milbrandt J (Oct 1996). "Ninjurin, a novel adhesion molecule, is induced by nerve injury and promotes axonal growth". Neuron. 17 (2): 353–61. doi:10.1016/S0896-6273(00)80166-X. PMID 8780658. S2CID 12471778.

[entrez-6] "Entrez Gene: NINJ1 ninjurin 1".

[UniProt-7] "UniProt, Q92982". Pristupljeno 10. 9. 2021.

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