NFRKB
Jedarni faktor srodan kapa-B-vezujućem proteinu je protein koji je kod ljudi kodiran genom NFRKB.[5][6]
Aminokiselinska sekvenca
urediDužina polipeptidnog lanca je 1.299 aminokiselina, a molekulska težina 139.001 Da.[7]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MDSLDHMLTD | PLELGPCGDG | HGTRIMEDCL | LGGTRVSLPE | DLLEDPEIFF | ||||
| DVVSLSTWQE | VLSDSQREHL | QQFLPQFPED | SAEQQNELIL | ALFSGENFRF | ||||
| GNPLHIAQKL | FRDGHFNPEV | VKYRQLCFKS | QYKRYLNSQQ | QYFHRLLKQI | ||||
| LASRSDLLEM | ARRSGPALPF | RQKRPSPSRT | PEEREWRTQQ | RYLKVLREVK | ||||
| EECGDTALSS | DEEDLSSWLP | SSPARSPSPA | VPLRVVPTLS | TTDMKTADKV | ||||
| ELGDSDLKIM | LKKHHEKRKH | QPDHPDLLTG | DLTLNDIMTR | VNAGRKGSLA | ||||
| ALYDLAVLKK | KVKEKEEKKK | KKIKTIKSEA | EDLAEPLSST | EGVAPLSQAP | ||||
| SPLAIPAIKE | EPLEDLKPCL | GINEISSSFF | SLLLEILLLE | SQASLPMLEE | ||||
| RVLDWQSSPA | SSLNSWFSAA | PNWAELVLPA | LQYLAGESRA | VPSSFSPFVE | ||||
| FKEKTQQWKL | LGQSQDNEKE | LAALFQLWLE | TKDQAFCKQE | NEDSSDATTP | ||||
| VPRVRTDYVV | RPSTGEEKRV | FQEQERYRYS | QPHKAFTFRM | HGFESVVGPV | ||||
| KGVFDKETSL | NKAREHSLLR | SDRPAYVTIL | SLVRDAAARL | PNGEGTRAEI | ||||
| CELLKDSQFL | APDVTSTQVN | TVVSGALDRL | HYEKDPCVKY | DIGRKLWIYL | ||||
| HRDRSEEEFE | RIHQAQAAAA | KARKALQQKP | KPPSKVKSSS | KESSIKVLSS | ||||
| GPSEQSQMSL | SDSSMPPTPV | TPVTPTTPAL | PAIPISPPPV | SAVNKSGPST | ||||
| VSEPAKSSSG | VLLVSSPTMP | HLGTMLSPAS | SQTAPSSQAA | ARVVSHSGSA | ||||
| GLSQVRVVAQ | PSLPAVPQQS | GGPAQTLPQM | PAGPQIRVPA | TATQTKVVPQ | ||||
| TVMATVPVKA | QTTAATVQRP | GPGQTGLTVT | SLPATASPVS | KPATSSPGTS | ||||
| APSASTAAVI | QNVTGQNIIK | QVAITGQLGV | KPQTGNSIPL | TATNFRIQGK | ||||
| DVLRLPPSSI | TTDAKGQTVL | RITPDMMATL | AKSQVTTVKL | TQDLFGTGGN | ||||
| TTGKGISATL | HVTSNPVHAA | DSPAKASSAS | APSSTPTGTT | VVKVTPDLKP | ||||
| TEASSSAFRL | MPALGVSVAD | QKGKSTVASS | EAKPAATIRI | VQGLGVMPPK | ||||
| AGQTITVATH | AKQGASVASG | SGTVHTSAVS | LPSMNAAVSK | TVAVASGAAS | ||||
| TPISISTGAP | TVRQVPVSTT | VVSTSQAGKL | PTRITVPLSV | ISQPMKGKSV | ||||
| VTAPIIKGNL | GANLSGLGRN | IILTTMPAGT | KLIAGNKPVS | FLTAQQLQQL | ||||
| QQQGQATQVR | IQTVPASHLQ | QGTASGSSKA | VSTVVVTTAP | SPKQAPEQQ |
Reference
uredi- ^ a b c GRCh38: Ensembl release 89: ENSG00000170322 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000042185 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Adams BS, Leung K, Meltzer PS, Lewis KA, Wagner-McPherson C, Evans GA, Nabel GJ (Dec 1992). "Localization of the gene encoding R kappa B (NFRKB), a tissue-specific DNA binding protein, to chromosome 11q24-q25" (PDF). Genomics. 14 (2): 270–4. doi:10.1016/S0888-7543(05)80216-2. hdl:2027.42/29810. PMID 1427843.
- ^ "Entrez Gene: NFRKB nuclear factor related to kappaB binding protein".
- ^ "UniProt, Q6P4R8". Pristupljeno 25. 8. 2021.
Dopunska literatura
uredi- Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
- Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Urban MB, Schreck R, Baeuerle PA (1991). "NF-kappa B contacts DNA by a heterodimer of the p50 and p65 subunit". EMBO J. 10 (7): 1817–25. doi:10.1002/j.1460-2075.1991.tb07707.x. PMC 452856. PMID 2050119.
- Adams BS, Leung KY, Hanley EW, Nabel GJ (1992). "Cloning of R kappa B, a novel DNA-binding protein that recognizes the interleukin-2 receptor alpha chain kappa B site". New Biol. 3 (11): 1063–73. PMID 1777480.