NAP1L4
Proteinoliki protein 4 nukleosomnog sklopa je protein koji je kod ljudi kodiran genom NAP1L4.[5][6]
Ovaj gen kodira člana porodice nukleosomskih sklopnih proteina (NAP) koji mogu stupiti u interakciju i s jedrom i sa vezivnim histonima. Može se kretati između citoplazme i jedra, što ukazuje na ulogu histonskog šaperona. Ovaj gen je jedan od nekoliko koji se nalazi u blizini konzerviranog domena gena 11p15.5, važne regije supresorskog tumorskog gena. Promjene u ovoj regiji povezane su sa Beckwith-Wiedemannovim sindromom, Wilmsovim tumorom, rabdomiosarkomom, karcinomom kore nadbubrežne žlijezda i pluća, jajnika i dojke.[6]
Aminokiselinska sekvenca
urediDužina polipeptidnog lanca je 375 aminokiselina, a molekulska težina 42.823 Da.[7].
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MADHSFSDGV | PSDSVEAAKN | ASNTEKLTDQ | VMQNPRVLAA | LQERLDNVPH | ||||
| TPSSYIETLP | KAVKRRINAL | KQLQVRCAHI | EAKFYEEVHD | LERKYAALYQ | ||||
| PLFDKRREFI | TGDVEPTDAE | SEWHSENEEE | EKLAGDMKSK | VVVTEKAAAT | ||||
| AEEPDPKGIP | EFWFTIFRNV | DMLSELVQEY | DEPILKHLQD | IKVKFSDPGQ | ||||
| PMSFVLEFHF | EPNDYFTNSV | LTKTYKMKSE | PDKADPFSFE | GPEIVDCDGC | ||||
| TIDWKKGKNV | TVKTIKKKQK | HKGRGTVRTI | TKQVPNESFF | NFFNPLKASG | ||||
| DGESLDEDSE | FTLASDFEIG | HFFRERIVPR | AVLYFTGEAI | EDDDNFEEGE | ||||
| EGEEEELEGD | EEGEDEDDAE | INPKV |
Reference
uredi- ^ a b c ENSG00000273562 GRCh38: Ensembl release 89: ENSG00000205531, ENSG00000273562 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000059119 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Hu RJ, Lee MP, Johnson LA, Feinberg AP (Mar 1997). "A novel human homologue of yeast nucleosome assembly protein, 65 kb centromeric to the p57KIP2 gene, is biallelically expressed in fetal and adult tissues". Hum Mol Genet. 5 (11): 1743–8. doi:10.1093/hmg/5.11.1743. PMID 8923002.
- ^ a b "Entrez Gene: NAP1L4 nucleosome assembly protein 1-like 4".
- ^ "UniProt, Q99733". Pristupljeno 24. 8. 2021.
Dopunska literatura
uredi- Rodriguez P, Munroe D, Prawitt D, et al. (1997). "Functional characterization of human nucleosome assembly protein-2 (NAP1L4) suggests a role as a histone chaperone". Genomics. 44 (3): 253–65. doi:10.1006/geno.1997.4868. PMID 9325046.
- Rodriguez P, Pelletier J, Price GB, Zannis-Hadjopoulos M (2000). "NAP-2: histone chaperone function and phosphorylation state through the cell cycle". J. Mol. Biol. 298 (2): 225–38. doi:10.1006/jmbi.2000.3674. PMID 10764593.
- Shikama N, Chan HM, Krstic-Demonacos M, et al. (2000). "Functional interaction between nucleosome assembly proteins and p300/CREB-binding protein family coactivators". Mol. Cell. Biol. 20 (23): 8933–43. doi:10.1128/MCB.20.23.8933-8943.2000. PMC 86548. PMID 11073993.
- Cicala C, Arthos J, Selig SM, et al. (2002). "HIV envelope induces a cascade of cell signals in non-proliferating target cells that favor virus replication". Proc. Natl. Acad. Sci. U.S.A. 99 (14): 9380–5. Bibcode:2002PNAS...99.9380C. doi:10.1073/pnas.142287999. PMC 123149. PMID 12089333.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Rodriguez P, Ruiz MT, Price GB, Zannis-Hadjopoulos M (2005). "NAP-2 is part of multi-protein complexes in HeLa cells". J. Cell. Biochem. 93 (2): 398–408. doi:10.1002/jcb.20163. PMID 15368365. S2CID 12368640.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
- Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.