MUPCDH
Mucinski i kadherinoliki protein je protein koji je kod ljudi kodiran genom MUPCDH.[5][6][7]
Ovaj gen je novi gen sličan mucinu koji je član potporodice kadherina. Dok kodiranje mucinskih nepolimorfnih tandemskih ponavljanja bogatih prolinom, serinom i s treoninom sličnih proteina, gen također sadrži sekvencu kojs kodira motive vezanja kalcija koji se nalaze u svim kadherinima. Uloga hibridne vanćelijske regije i specifična funkcija ovog proteina još nisu utvrđene. Identificiran je alternativna prerada, pri čemu je uočena varijacija rezultirala prisutnošću ili odsutnošću domena. Osim toga, dolazi do spajanja u 5' UTR-a, ali transkripti, uključujući i ove varijante nisu u potpunosti opisani.[7]
Aminokiselinska sekvenca uredi
Dužina polipeptidnog lanca je 845 aminokiselina, a molekulska težina 88.223 Da.[8]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MGSWALLWPP | LLFTGLLVRP | PGTMAQAQYC | SVNKDIFEVE | ENTNVTEPLV | ||||
| DIHVPEGQEV | TLGALSTPFA | FRIQGNQLFL | NVTPDYEEKS | LLEAQLLCQS | ||||
| GGTLVTQLRV | FVSVLDVNDN | APEFPFKTKE | IRVEEDTKVN | STVIPETQLQ | ||||
| AEDRDKDDIL | FYTLQEMTAG | ASDYFSLVSV | NRPALRLDRP | LDFYERPNMT | ||||
| FWLLVRDTPG | ENVEPSHTAT | ATLVLNVVPA | DLRPPWFLPC | TFSDGYVCIQ | ||||
| AQYHGAVPTG | HILPSPLVLR | PGPIYAEDGD | RGINQPIIYS | IFRGNVNGTF | ||||
| IIHPDSGNLT | VARSVPSPMT | FLLLVKGQQA | DLARYSVTQV | TVEAVAAAGS | ||||
| PPRFPQRLYR | GTVARGAGAG | VVVKDAAAPS | QPLRIQAQDP | EFSDLNSAIT | ||||
| YRITNHSHFR | MEGEVVLTTT | TLAQAGAFYA | EVEAHNTVTS | GTATTVIEIQ | ||||
| VSEQEPPSTD | VPPSPEAGGT | TGPWTSTTSE | VPRPPEPSQG | PSTTSSGGGT | ||||
| GPHPPSGTTL | RPPTSSTPGG | PPGAENSTSH | QPATPGGDTA | QTPKPGTSQP | ||||
| MPPGVGTSTS | HQPATPSGGT | AQTPEPGTSQ | PMPPSMGTST | SHQPATPGGG | ||||
| TAQTPEAGTS | QPMPPGMGTS | TSHQPTTPGG | GTAQTPEPGT | SQPMPLSKST | ||||
| PSSGGGPSED | KRFSVVDMAA | LGGVLGALLL | LALLGLAVLV | HKHYGPRLKC | ||||
| CCGKAPEPQP | QGFDNQAFLP | DHKANWAPVP | SPTHDPKPAE | APMPAEPAPP | ||||
| GPASPGGAPE | PPAAARAGGS | PTAVRSILTK | ERRPEGGYKA | VWFGEDIGTE | ||||
| ADVVVLNAPT | LDVDGASDSG | SGDEGEGAGR | GGGPYDAPGG | DDSYI |
Reference uredi
- ^ a b c ENSG00000273572 GRCh38: Ensembl release 89: ENSG00000099834, ENSG00000273572 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025497 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Paris MJ, Williams BR (Jan 2001). "Characterization of a 500-kb contig spanning the region between c-Ha-Ras and MUC2 on chromosome 11p15.5". Genomics. 69 (2): 196–202. doi:10.1006/geno.2000.6339. PMID 11031102.
- ^ Goldberg M, Peshkovsky C, Shifteh A, Al-Awqati Q (Sep 2000). "mu-Protocadherin, a novel developmentally regulated protocadherin with mucin-like domains". J Biol Chem. 275 (32): 24622–9. doi:10.1074/jbc.M000234200. PMID 10801787. S2CID 42493271.
- ^ a b "Entrez Gene: MUCDHL mucin and cadherin-like".
- ^ "UniProt, Q9HBB8". Pristupljeno 19. 8. 2021.
Dopunska literatura uredi
- Yagi T, Takeichi M (2000). "Cadherin superfamily genes: functions, genomic organization, and neurologic diversity". Genes Dev. 14 (10): 1169–80. doi:10.1101/gad.14.10.1169 (neaktivno 31. 5. 2021). PMID 10817752.CS1 održavanje: DOI nije aktivan od 2021 (link)
- Goldberg M, Wei M, Tycko B, et al. (2002). "Identification and expression analysis of the human mu-protocadherin gene in fetal and adult kidneys". Am. J. Physiol. Renal Physiol. 283 (3): F454–63. doi:10.1152/ajprenal.00012.2002. PMID 12167596. S2CID 615952.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Goldberg M, Wei M, Yuan L, et al. (2003). "Biallelic expression of HRAS and MUCDHL in human and mouse". Hum. Genet. 112 (4): 334–42. doi:10.1007/s00439-003-0907-7. PMID 12589428. S2CID 1143721.
- Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. S2CID 21903526.
- Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human Plasma N-Glycoproteome Analysis by Immunoaffinity Subtraction, Hydrazide Chemistry, and Mass Spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.