MRPS18B

MRPS18B
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	3J9M
Identifikatori
Aliasi	MRPS18B
Vanjski ID-jevi	OMIM: 611982 MGI: 1914223 HomoloGene: 32205 GeneCards: MRPS18B
Lokacija gena (čovjek)
Hrom.	Hromosom 6 (čovjek)
Kraj	30,626,395 bp
Lokacija gena (miš)
Hrom.	Hromosom 17 (miš)
Kraj	36,227,281 bp
Obrazac RNK ekspresije
	; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• structural constituent of ribosome; • GO:0001948, GO:0016582 vezivanje za proteine;
Ćelijska komponenta	• međućelijske veze; • ribozom; • nukleoplazma; • intracellular anatomical structure; • mitochondrial inner membrane; • mitochondrial small ribosomal subunit; • mitohondrija;
Biološki proces	• mitochondrial translational elongation; • Biosinteza bjelančevina; • mitochondrial translational termination; • mitochondrial translation;
	Izvori:Amigo / QuickGO
Ortolozi
	28973
	66973
ENSG00000229861; ENSG00000226111; ENSG00000204568; ENSG00000203624; ENSG00000227420;
	ENSG00000233813; ENSG00000223775
	ENSMUSG00000024436
	Q9Y676
	Q99N84
	NM_014046
	NM_025878; NM_001347380; NM_001361453; NM_001361454; NM_001361455
	NP_054765
	NP_001334309; NP_080154; NP_001348382; NP_001348383; NP_001348384
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Mitohondrijski 28S ribosomski protein S18b jest protein koji je kod ljudi kodiran genom MRPS18B.^[5]^[6]

Aminokiselinska sekvenca uredi

Dužina polipeptidnog lanca je 258 aminokiselina, а molekulska težina 29.396 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MAASVLNTVL	RRLPMLSLFR	GSHRVQVPLQ	TLCTKAPSEE	DSLSSVPISP
YKDEPWKYLE	SEEYQERYGS	RPVWADYRRN	HKGGVPPQRT	RKTCIRRNKV
VGNPCPICRD	HKLHVDFRNV	KLLEQFVCAH	TGIIFYAPYT	GVCVKQHKRL
TQAIQKARDH	GLLIYHIPQV	EPRDLDFSTS	HGAVSATPPA	PTLVSGDPWY
PWYNWKQPPE	RELSRLRRLY	QGHLQEESGP	PPESMPKMPP	RTPAEASSTG
QTGPQSAL

Funkcija uredi

Mitohondrijski ribosomski proteini sisara kodirani su jedarnim genima i pomažu u sintezi proteina unutar mitohondrija. Mitohondrijski ribosomi (mitoribosomi) sastoje se od male podjedinice 28S i velike podjedinice 39S. Imaju procijenjenih 75% proteina prema rRNK sastavu u poređenju sa prokariotskim ribosomima, gdje je ovaj odnos obrnut.

Druga razlika između mitoribosoma sisara i prokariotskih ribosoma je ta što ovi drugi sadrže 5S rRNK. Među različitim vrstama, proteini koji se sastoje od mitoribosoma uveliko se razlikuju po sekvenci, a ponekad i po biohemijskim svojstvima, što sprečava lahko prepoznavanje homologija po sekvenci. Ovaj gen kodira protein podjedinice 28S koji pripada porodici ribosomnih proteina S18P. Kodirani protein jedan je od tri koji ima značajnu sličnost u sekvenci sa bakterijskim proteinima S18. Primarni transkripti tri ljudska mitohondrijska proteina S18 nisu međusobno bliskije povezane s prokariotskim proteinima S18. Pseudogeni koji odgovaraju ovom genu nalaze se na dugim kracima (q) hromozoma 1 i 2.^[6]

Reference uredi

^ ^a ^b ^c ENSG00000226111, ENSG00000204568, ENSG00000203624, ENSG00000227420, ENSG00000233813, ENSG00000223775 GRCh38: Ensembl release 89: ENSG00000229861, ENSG00000226111, ENSG00000204568, ENSG00000203624, ENSG00000227420, ENSG00000233813, ENSG00000223775 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024436 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Cavdar Koc E, Burkhart W, Blackburn K, Moseley A, Spremulli LL (maj 2001). "The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present". J Biol Chem. 276 (22): 19363–74. doi:10.1074/jbc.M100727200. PMID 11279123.
^ ^a ^b "Entrez Gene: MRPS18B mitochondrial ribosomal protein S18B".
^ "UniProt, Q9Y676" (jezik: engleski). Pristupljeno 3. 10. 2021.

Dopunska literatura uredi

Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
Shiina T, Ota M, Shimizu S, et al. (2006). "Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity". Genetics. 173 (3): 1555–70. doi:10.1534/genetics.106.057034. PMC 1526686. PMID 16702430.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Zhang Z, Gerstein M (2003). "Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome". Genomics. 81 (5): 468–80. doi:10.1016/S0888-7543(03)00004-1. PMID 12706105.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Suzuki T, Terasaki M, Takemoto-Hori C, et al. (2001). "Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28 S small subunit". J. Biol. Chem. 276 (35): 33181–95. doi:10.1074/jbc.M103236200. PMID 11402041.
Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.

[refGRCh38Ensembl-1] ENSG00000226111, ENSG00000204568, ENSG00000203624, ENSG00000227420, ENSG00000233813, ENSG00000223775 GRCh38: Ensembl release 89: ENSG00000229861, ENSG00000226111, ENSG00000204568, ENSG00000203624, ENSG00000227420, ENSG00000233813, ENSG00000223775 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024436 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11279123-5] Cavdar Koc E, Burkhart W, Blackburn K, Moseley A, Spremulli LL (maj 2001). "The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present". J Biol Chem. 276 (22): 19363–74. doi:10.1074/jbc.M100727200. PMID 11279123.

[entrez-6] "Entrez Gene: MRPS18B mitochondrial ribosomal protein S18B".

[UniProt-7] "UniProt, Q9Y676" (jezik: engleski). Pristupljeno 3. 10. 2021.

[5]

[6]

[1]

[2]

[3]

[4]

[7]