LUC7L3

LUC7-oliki 3 pre-iRNK faktor prerade (LUC7L3), znan i kao preeksprimirani protein vezan sa rezistencijom na cisplatin ili CROP je ljudski gen.

LUC7L3
Identifikatori
Aliasi	LUC7L3
Vanjski ID-jevi	OMIM: 609434 MGI: 1914934 HomoloGene: 75056 GeneCards: LUC7L3
Lokacija gena (čovjek) Hrom. Hromosom 17 (čovjek) Bend 17q21.33 Početak 50,719,565 bp Kraj 50,756,219 bp
Lokacija gena (miš) Hrom. Hromosom 11 (miš) Bend 11|11 D Početak 94,178,716 bp Kraj 94,212,814 bp
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • vezivanje sa DNK • GO:0001948, GO:0016582 vezivanje za proteine • mRNA binding • vezivanje sa RNK Ćelijska komponenta • U1 snRNP • U2-type prespliceosome • jedro • nukleoplazma • nuclear speck Biološki proces • mRNA processing • mRNA splice site selection • Prerada RNK Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	51747	67684
Ensembl	ENSG00000108848	ENSMUSG00000020863
UniProt	O95232	Q5SUF2
RefSeq (mRNK)	NM_006107 NM_016424 NM_001330330	NM_026313 NM_001361573 NM_001361574 NM_001361575
RefSeq (bjelančevina)	NP_001317259 NP_006098 NP_057508	NP_080589 NP_001348502 NP_001348503 NP_001348504
Lokacija (UCSC)	Chr 17: 50.72 – 50.76 Mb	Chr 11: 94.18 – 94.21 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Ovaj gen kodira preeksprimirani protein povezan sa rezistencijom na cisplatin (CROP). N-terminalna polovina CROP-a sadrži motive cistein/histidina i leucinska ponavljanja poput patentnih zatvarača, a C-terminalna polovina bogata je arginininskim i glutamatnim ostacima (RE domen) i argininskim i serinskim ostacima (RS domen). Ovaj protein lokalizira se tačkastim obrascem u jedru i mogao bi biti uključen u stvaranje splajsosom, putem RE i RS domena. Pronađene su dvije varijante transkripta kojE kodiraju isti protein ovog gena.

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 432 aminokiseline, a molekulska težina 51.466 Da..

10		20		30		40		50
MISAAQLLDE		LMGRDRNLAP		DEKRSNVRWD		HESVCKYYLC		GFCPAELFTN
TRSDLGPCEK		IHDENLRKQY		EKSSRFMKVG		YERDFLRYLQ		SLLAEVERRI
RRGHARLALS		QNQQSSGAAG		PTGKNEEKIQ		VLTDKIDVLL		QQIEELGSEG
KVEEAQGMMK		LVEQLKEERE		LLRSTTSTIE		SFAAQEKQME		VCEVCGAFLI
VGDAQSRVDD		HLMGKQHMGY		AKIKATVEEL		KEKLRKRTEE		PDRDERLKKE
KQEREEREKE		REREREERER		KRRREEEERE		KERARDRERR		KRSRSRSRHS
SRTSDRRCSR		SRDHKRSRSR		ERRRSRSRDR		RRSRSHDRSE		RKHRSRSRDR
RRSKSRDRKS		YKHRSKSRDR		EQDRKSKEKE		KRGSDDKKSS		VKSGSREKQS
EDTNTESKES		DTKNEVNGTS		EDIKSEGDTQ		SN

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

Dopunska literatura

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Nishii Y, Morishima M, Kakehi Y, et al. (2000). "CROP/Luc7A, a novel serine/arginine-rich nuclear protein, isolated from cisplatin-resistant cell line". FEBS Lett. 465 (2–3): 153–6. doi:10.1016/S0014-5793(99)01744-5. PMID 10631324. S2CID 7918526.
• Chin LS, Singh SK, Wang Q, Murray SF (2000). "Identification of okadaic-acid-induced genes by mRNA differential display in glioma cells". J. Biomed. Sci. 7 (2): 152–9. doi:10.1007/BF02256622. PMID 10754390.
• Harrington JJ, Sherf B, Rundlett S, et al. (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression". Nat. Biotechnol. 19 (5): 440–5. doi:10.1038/88107. PMID 11329013. S2CID 25064683.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Umehara H, Nishii Y, Morishima M, et al. (2003). "Effect of cisplatin treatment on speckled distribution of a serine/arginine-rich nuclear protein CROP/Luc7A". Biochem. Biophys. Res. Commun. 301 (2): 324–9. doi:10.1016/S0006-291X(02)03017-6. PMID 12565863.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
• Brown V, Brown RA, Ozinsky A, et al. (2006). "Binding specificity of Toll-like receptor cytoplasmic domains". Eur. J. Immunol. 36 (3): 742–53. doi:10.1002/eji.200535158. PMC 2762736. PMID 16482509.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
• Puig O, Bragado-Nilsson E, Koski T, Séraphin B (2007). "The U1 snRNP-associated factor Luc7p affects 5' splice site selection in yeast and human". Nucleic Acids Res. 35 (17): 5874–85. doi:10.1093/nar/gkm505. PMC 2034479. PMID 17726058.

Vanjski linkovi

• Lokacija ljudskog genoma LUC7L3 i stranica sa detaljima o genu LUC7L3 u UCSC Genome Browseru.