LPXN

Leupaksin je protein koji je kod ljudi kodiran genom LPXN.

LPXN
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 1X3H, 4XEF, 4XEK, 4XEV
Identifikatori
Aliasi	LPXN
Vanjski ID-jevi	OMIM: 605390 MGI: 2147677 HomoloGene: 3536 GeneCards: LPXN
Lokacija gena (čovjek) Hrom. Hromosom 11 (čovjek) Bend 11q12.1 Početak 58,526,871 bp Kraj 58,578,220 bp
Lokacija gena (miš) Hrom. Hromosom 19 (miš) Bend 19|19 A Početak 12,773,557 bp Kraj 12,811,171 bp
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • GO:0001948, GO:0016582 vezivanje za proteine • GO:0001104 transcription coregulator activity • vezivanje iona metala Ćelijska komponenta • citoplazma • perinuklearno područje citoplazme • podosome • međućelijske veze • ćelijska membrana • projekcija ćelije • jedro • focal adhesion • membrana • citosol • nuclear speck Biološki proces • negative regulation of B cell receptor signaling pathway • negative regulation of cell adhesion • Ćelijska adhezija • regulation of cell adhesion mediated by integrin • GO:0009373 regulation of transcription, DNA-templated • transcription, DNA-templated • GO:0072468 Transdukcija signala • GO:0034622 protein-containing complex assembly • regulation of nucleic acid-templated transcription Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	9404	107321
Ensembl	ENSG00000110031	ENSMUSG00000024696
UniProt	O60711	Q99N69
RefSeq (mRNK)	NM_001143995 NM_001307951 NM_004811	NM_134152 NM_001361971
RefSeq (bjelančevina)	NP_001137467 NP_001294880 NP_004802	NP_598913 NP_001348900
Lokacija (UCSC)	Chr 11: 58.53 – 58.58 Mb	Chr 19: 12.77 – 12.81 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Proizvod kodiran ovim genom preferirano se eksprimira u hematopoetskim ćelijama i najhomologniji je fokusnom adhezijskom proteinu, paksilinu. Može funkcionirati u signalizaciji specifičnoj za tip ćelije povezujući se s PYK2, članom porodice fokusih adhezionih kinaza. Kao supstrat za tirozin-kinazu u limfoidnim ćelijama, ovaj protein također može funkcionirati i biti reguliran aktivnošću tirozin-kinaze.

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 386 aminokiselina, a molekulska težina 43.332 Da.

10		20		30		40		50
MEELDALLEE		LERSTLQDSD		EYSNPAPLPL		DQHSRKETNL		DETSEILSIQ
DNTSPLPAQL		VYTTNIQELN		VYSEAQEPKE		SPPPSKTSAA		AQLDELMAHL
TEMQAKVAVR		ADAGKKHLPD		KQDHKASLDS		MLGGLEQELQ		DLGIATVPKG
HCASCQKPIA		GKVIHALGQS		WHPEHFVCTH		CKEEIGSSPF		FERSGLAYCP
NDYHQLFSPR		CAYCAAPILD		KVLTAMNQTW		HPEHFFCSHC		GEVFGAEGFH
EKDKKPYCRK		DFLAMFSPKC		GGCNRPVLEN		YLSAMDTVWH		PECFVCGDCF
TSFSTGSFFE		LDGRPFCELH		YHHRRGTLCH		GCGQPITGRC		ISAMGYKFHP
EHFVCAFCLT		QLSKGIFREQ		NDKTYCQPCF		NKLFPL

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

Dopunska literatura

• Chew V, Lam KP (2007). "Leupaxin negatively regulates B cell receptor signaling". J. Biol. Chem. 282 (37): 27181–91. doi:10.1074/jbc.M704625200. PMID 17640867.
• Sahu SN, Nunez S, Bai G, Gupta A (2007). "Interaction of Pyk2 and PTP-PEST with leupaxin in prostate cancer cells". Am. J. Physiol., Cell Physiol. 292 (6): C2288–96. doi:10.1152/ajpcell.00503.2006. PMID 17329398.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Tao WA, Wollscheid B, O'Brien R, et al. (2005). "Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry". Nat. Methods. 2 (8): 591–8. doi:10.1038/nmeth776. PMID 16094384. S2CID 20475874.
• Watanabe N, Amano N, Ishizuka H, Mashima K (2005). "Leupaxin binds to PEST domain tyrosine phosphatase PEP". Mol. Cell. Biochem. 269 (1–2): 13–7. doi:10.1007/s11010-005-2149-6. PMID 15786712. S2CID 21854825.
• Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
• Gupta A, Lee BS, Khadeer MA, et al. (2003). "Leupaxin is a critical adaptor protein in the adhesion zone of the osteoclast". J. Bone Miner. Res. 18 (4): 669–85. doi:10.1359/jbmr.2003.18.4.669. PMID 12674328. S2CID 24743841.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Liu S, Thomas SM, Woodside DG, et al. (2000). "Binding of paxillin to alpha4 integrins modifies integrin-dependent biological responses". Nature. 402 (6762): 676–81. doi:10.1038/45264. PMID 10604475. S2CID 2770368.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.