LOC642658

LOC642658
Identifikatori
Aliasi	SCX
Vanjski ID-jevi	OMIM: 609067 MGI: 102934 HomoloGene: 85195 GeneCards: SCX
Lokacija gena (čovjek)
Hrom.	Hromosom 8 (čovjek)
Kraj	144,268,481 bp
Lokacija gena (miš)
Hrom.	Hromosom 15 (miš)
Kraj	76,343,658 bp
Ontologija gena
Molekularna funkcija	• GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • vezivanje sa DNK; • sequence-specific DNA binding; • protein dimerization activity; • bHLH transcription factor binding; • E-box binding; • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific; • protein heterodimerization activity; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific;
Ćelijska komponenta	• transcription regulator complex; • jedro;
Biološki proces	• cellular response to transforming growth factor beta stimulus; • positive regulation of collagen biosynthetic process; • Ćelijska diferencijacija; • GO:0009373 regulation of transcription, DNA-templated; • chondrocyte differentiation; • regulation of cartilage development; • positive regulation of gastrulation; • collagen fibril organization; • tendon development; • tendon cell differentiation; • mesoderm formation; • cellular response to BMP stimulus; • negative regulation of apoptotic process; • Sertoli cell differentiation; • endochondral ossification; • transcription by RNA polymerase II; • BMP signaling pathway; • transcription, DNA-templated; • sclerotome development; • embryonic skeletal system development; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • multicellular organism development; • deltoid tuberosity development; • cellular response to mechanical stimulus; • GO:1901313 positive regulation of gene expression; • heart valve formation; • positive regulation of cartilage development; • heart valve morphogenesis; • tissue homeostasis; • positive regulation of cell population proliferation; • tendon formation; • skeletal muscle cell differentiation; • GO:0045996 negative regulation of transcription, DNA-templated; • face morphogenesis; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II;
	Izvori:Amigo / QuickGO
Ortolozi
	642658
	20289
	ENSG00000260428
	ENSMUSG00000034161
	Q7RTU7
	Q64124
	NM_001008271; NM_001080514
	NM_198885
	NP_001073983
	NP_942588
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Osnovni skleraksni transkripcijski faktor heliks-petlja-heliks je protein koji je kod ljudi kodiran genom SCXB.^[5]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 201 aminokiselina, а molekulska težina 21.596 Da.^[6]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MSFATLRPAP	PGRYLYPEVS	PLSEDEDRGS	DSSGSDEKPC	RVHAARCGLQ
GARRRAGGRR	AGGGGPGGRP	GREPRQRHTA	NARERDRTNS	VNTAFTALRT
LIPTEPADRK	LSKIETLRLA	SSYISHLGNV	LLAGEACGDG	QPCHSGPAFF
HAARAGSPPP	PPPPPPARDG	ENTQPKQICT	FCLSNQRKLS	KDRDRKTAIR
S

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000260428 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000034161 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: LOC642658 similar to Basic helix-loop-helix transcription factor scleraxis".
^ "UniProt, Q7RTU7" (jezik: engleski). Pristupljeno 19. 9. 2021.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000260428 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000034161 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: LOC642658 similar to Basic helix-loop-helix transcription factor scleraxis".

[UniProt-6] "UniProt, Q7RTU7" (jezik: engleski). Pristupljeno 19. 9. 2021.

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