LARP4

LARP4
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	2CQK, 3PKN
Identifikatori
Aliasi	LARP4
Vanjski ID-jevi	MGI: 2443114 HomoloGene: 19173 GeneCards: LARP4
Lokacija gena (miš)
Hrom.	Hromosom 15 (miš)
Kraj	99,914,239 bp
Obrazac RNK ekspresije
	; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine; • nucleic acid binding; • poly(A) binding; • vezivanje sa RNK;
Ćelijska komponenta	• membrana; • polysome; • cytoplasmic stress granule; • cytosolic small ribosomal subunit; • citoplazma; • citosol;
Biološki proces	• regulation of cell morphogenesis; • cytoskeleton organization; • positive regulation of translation; • Biosinteza bjelančevina;
	Izvori:Amigo / QuickGO
Ortolozi
	113251
	207214
	ENSG00000161813
	ENSMUSG00000023025
	Q71RC2
	Q8BWW4
NM_001170803; NM_001170804; NM_001170808; NM_052879; NM_199188;
	NM_199190; NM_001330415
	NM_001024526; NM_001080948; NM_001284521; NM_001284522; NM_001284523
NP_001164274; NP_001164275; NP_001164279; NP_001317344; NP_443111;
	NP_954658; NP_954660; NP_001339233; NP_001339234; NP_001339235; NP_001339236; NP_001339237; NP_001339238; NP_001339239; NP_001339240; NP_001339241; NP_001339242; NP_001339243; NP_001339244; NP_001339245; NP_001339246; NP_001339247; NP_001339248; NP_001339249; NP_001339250; NP_001339251; NP_001339252; NP_001339253; NP_001339254; NP_001339255
	NP_001019697; NP_001074417; NP_001271450; NP_001271451; NP_001271452
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

La-srodni protein 4 je protein koji je kod ljudi kodiran genom LARP4.^[4]^[5] LARP4 je protein koji se veže za RNK i sastoji se od motiva La (LaM), motiva za prepoznavanje RNK (RRM) i navodnog motiva vezivanja PABP. Pokazano je da je LARP4 uključen u stabilnost iRNK.^[6]

Poznato je da LARP4 regulira migraciju i invaziju ćelija raka, promjenom njihovog oblika.^[7] Također je objavljeno da je supresorski gen gliomskog tumora.^[8]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 724 aminokiseline, a molekulska težina 80.596 Da.^[9].

10	20	30	40	50
MLLFVEQVAS	KGTGLNPNAK	VWQEIAPGNT	DATPVTHGTE	SSWHEIAATS
GAHPEGNAEL	SEDICKEYEV	MYSSSCETTR	NTTGIEESTD	GMILGPEDLS
YQIYDVSGES	NSAVSTEDLK	ECLKKQLEFC	FSRENLSKDL	YLISQMDSDQ
FIPIWTVANM	EEIKKLTTDP	DLILEVLRSS	PMVQVDEKGE	KVRPSHKRCI
VILREIPETT	PIEEVKGLFK	SENCPKVISC	EFAHNSNWYI	TFQSDTDAQQ
AFKYLREEVK	TFQGKPIMAR	IKAINTFFAK	NGYRLMDSSI	YSHPIQTQAQ
YASPVFMQPV	YNPHQQYSVY	SIVPQSWSPN	PTPYFETPLA	PFPNGSFVNG
FNSPGSYKTN	AAAMNMGRPF	QKNRVKPQFR	SSGGSEHSTE	GSVSLGDGQL
NRYSSRNFPA	ERHNPTVTGH	QEQTYLQKET	STLQVEQNGD	YGRGRRTLFR
GRRRREDDRI	SRPHPSTAES	KAPTPKFDLL	ASNFPPLPGS	SSRMPGELVL
ENRMSDVVKG	VYKEKDNEEL	TISCPVPADE	QTECTSAQQL	NMSTSSPCAA
ELTALSTTQQ	EKDLIEDSSV	QKDGLNQTTI	PVSPPSTTKP	SRASTASPCN
NNINAATAVA	LQEPRKLSYA	EVCQKPPKEP	SSVLVQPLRE	LRSNVVSPTK
NEDNGAPENS	VEKPHEKPEA	RASKDYSGFR	GNIIPRGAAG	KIREQRRQFS
HRAIPQGVTR	RNGKEQYVPP	RSPK

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

Reference

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000023025 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. (decembar 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences of the United States of America. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
^ "Entrez Gene: LARP4 La ribonucleoprotein domain family, member 4".
^ Yang R, Gaidamakov SA, Xie J, Lee J, Martino L, Kozlov G, Crawford AK, Russo AN, Conte MR, Gehring K, Maraia RJ (februar 2011). "La-related protein 4 binds poly(A), interacts with the poly(A)-binding protein MLLE domain via a variant PAM2w motif, and can promote mRNA stability". Molecular and Cellular Biology. 31 (3): 542–56. doi:10.1128/MCB.01162-10. PMC 3028612. PMID 21098120.
^ Seetharaman S, Flemyng E, Shen J, Conte MR, Ridley AJ (novembar 2016). "The RNA-binding protein LARP4 regulates cancer cell migration and invasion". Cytoskeleton. 73 (11): 680–690. doi:10.1002/cm.21336. PMC 5111583. PMID 27615744.
^ Koso H, Yi H, Sheridan P, Miyano S, Ino Y, Todo T, Watanabe S (april 2016). "Identification of RNA-Binding Protein LARP4B as a Tumor Suppressor in Glioma". Cancer Research. 76 (8): 2254–64. doi:10.1158/0008-5472.CAN-15-2308. PMID 26933087.
^ "UniProt, Q71RC2". Pristupljeno 11. 8. 2021.

Dopunska literatura

Stavraka C, Blagden S (oktobar 2015). "The La-Related Proteins, a Family with Connections to Cancer". Biomolecules. 5 (4): 2701–22. doi:10.3390/biom5042701. PMC 4693254. PMID 26501340.
Kralovics R, Skoda RC (januar 2005). "Molecular pathogenesis of Philadelphia chromosome negative myeloproliferative disorders". Blood Reviews. 19 (1): 1–13. doi:10.1016/j.blre.2004.02.002. PMID 15572213.
Puigdecanet E, Espinet B, Villa O, Florensa L, Besses C, Serrano S, Solé F (maj 2006). "Detection of abnormalities of PRV-1, TPO, and c-MPL genes detected by fluorescence in situ hybridization in essential thrombocythemia". Cancer Genetics and Cytogenetics. 167 (1): 39–42. doi:10.1016/j.cancergencyto.2005.08.016. PMID 16682284.
Wan D, Gong Y, Qin W, Zhang P, Li J, Wei L, Zhou X, Li H, Qiu X, Zhong F, He L, Yu J, Yao G, Jiang H, Qian L, Yu Y, Shu H, Chen X, Xu H, Guo M, Pan Z, Chen Y, Ge C, Yang S, Gu J (novembar 2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proceedings of the National Academy of Sciences of the United States of America. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (april 1997). "Large-scale concatenation cDNA sequencing". Genome Research. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (april 1996). "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.

Vanjski linkovi

[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000023025 - Ensembl, maj 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12477932-4] Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. (decembar 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences of the United States of America. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

[entrez-5] "Entrez Gene: LARP4 La ribonucleoprotein domain family, member 4".

[6] Yang R, Gaidamakov SA, Xie J, Lee J, Martino L, Kozlov G, Crawford AK, Russo AN, Conte MR, Gehring K, Maraia RJ (februar 2011). "La-related protein 4 binds poly(A), interacts with the poly(A)-binding protein MLLE domain via a variant PAM2w motif, and can promote mRNA stability". Molecular and Cellular Biology. 31 (3): 542–56. doi:10.1128/MCB.01162-10. PMC 3028612. PMID 21098120.

[7] Seetharaman S, Flemyng E, Shen J, Conte MR, Ridley AJ (novembar 2016). "The RNA-binding protein LARP4 regulates cancer cell migration and invasion". Cytoskeleton. 73 (11): 680–690. doi:10.1002/cm.21336. PMC 5111583. PMID 27615744.

[8] Koso H, Yi H, Sheridan P, Miyano S, Ino Y, Todo T, Watanabe S (april 2016). "Identification of RNA-Binding Protein LARP4B as a Tumor Suppressor in Glioma". Cancer Research. 76 (8): 2254–64. doi:10.1158/0008-5472.CAN-15-2308. PMID 26933087.

[UniProt-9] "UniProt, Q71RC2". Pristupljeno 11. 8. 2021.

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