KIF13B

KIF13B
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	2COW, 3FM8, 3GBJ, 3MDB
Identifikatori
Aliasi	KIF13B
Vanjski ID-jevi	OMIM: 607350 MGI: 1098265 HomoloGene: 9073 GeneCards: KIF13B
Lokacija gena (čovjek)
Hrom.	Hromosom 8 (čovjek)
Kraj	29,263,124 bp
Lokacija gena (miš)
Hrom.	Hromosom 14 (miš)
Kraj	65,047,066 bp
Ontologija gena
Molekularna funkcija	• microtubule motor activity; • nucleotide binding; • microtubule binding; • 14-3-3 protein binding; • ATPase activity; • GO:0001948, GO:0016582 vezivanje za proteine; • ATP binding; • protein kinase binding;
Ćelijska komponenta	• citoplazma; • citosol; • projekcija ćelije; • Kinezin; • microvillus; • Akson; • paranode region of axon; • Mikrotubula; • citoskelet;
Biološki proces	• Ciljanje proteina; • cytoskeleton-dependent intracellular transport; • regulation of axonogenesis; • microtubule-based movement; • T cell activation; • GO:0072468 Transdukcija signala;
	Izvori:Amigo / QuickGO
Ortolozi
	23303
	16554
	ENSG00000197892
	ENSMUSG00000060012
	Q9NQT8
	E9Q4K7
	NM_015254
	NM_001081177
	NP_056069
	NP_001074646
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Član 13B kinezinske porodice je protein koji je kod ljudi kodiran genom KIF13B.^[5]

Aminokiselinska sekvenca uredi

Dužina polipeptidnog lanca je 1.826 aminokiselina, а molekulska težina 202.789 Da.^[6]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MGDSKVKVAV	RIRPMNRRET	DLHTKCVVDV	DANKVILNPV	NTNLSKGDAR
GQPKVFAYDH	CFWSMDESVK	EKYAGQDIVF	KCLGENILQN	AFDGYNACIF
AYGQTGSGKS	YTMMGTADQP	GLIPRLCSGL	FERTQKEENE	EQSFKVEVSY
MEIYNEKVRD	LLDPKGSRQT	LKVREHSVLG	PYVDGLSKLA	VTSYKDIESL
MSEGNKSRTV	AATNMNEESS	RSHAVFKITL	THTLYDVKSG	TSGEKVGKLS
LVDLAGSERA	TKTGAAGDRL	KEGSNINKSL	TTLGLVISAL	ADQSAGKNKN
KFVPYRDSVL	TWLLKDSLGG	NSKTAMVATV	SPAADNYDET	LSTLRYADRA
KHIVNHAVVN	EDPNARIIRD	LREEVEKLRE	QLTKAEAMKS	PELKDRLEES
EKLIQEMTVT	WEEKLRKTEE	IAQERQKQLE	SLGISLQSSG	IKVGDDKCFL
VNLNADPALN	ELLVYYLKEH	TLIGSANSQD	IQLCGMGILP	EHCIIDITSE
GQVMLTPQKN	TRTFVNGSSV	SSPIQLHHGD	RILWGNNHFF	RLNLPKKKKK
AEREDEDQDP	SMKNENSSEQ	LDVDGDSSSE	VSSEVNFNYE	YAQMEVTMKA
LGSNDPMQSI	LNSLEQQHEE	EKRSALERQR	LMYEHELEQL	RRRLSPEKQN
CRSMDRFSFH	SPSAQQRLRQ	WAEEREATLN	NSLMRLREQI	VKANLLVREA
NYIAEELDKR	TEYKVTLQIP	ASSLDANRKR	GSLLSEPAIQ	VRRKGKGKQI
WSLEKLDNRL	LDMRDLYQEW	KECEEDNPVI	RSYFKRADPF	YDEQENHSLI
GVANVFLESL	FYDVKLQYAV	PIINQKGEVA	GRLHVEVMRL	SGDVGERIAG
GDEVAEVSFE	KETQENKLVC	MVKILQATGL	PQHLSHFVFC	KYSFWDQQEP
VIVAPEVDTS	SSSVSKEPHC	MVVFDHCNEF	SVNITEDFIE	HLSEGALAIE
VYGHKINDPR	KNPALWDLGI	IQAKTRSLRD	RWSEVTRKLE	FWVQILEQNE
NGEYCPVEVI	SAKDVPTGGI	FQLRQGQSRR	VQVEVKSVQE	SGTLPLMEEC
ILSVGIGCVK	VRPLRAPRTH	ETFHEEEEDM	DSYQDRDLER	LRRKWLNALT
KRQEYLDQQL	QKLVSKRDKT	EDDADREAQL	LEMRLTLTEE	RNAVMVPSAG
SGIPGAPAEW	TPVPGMETHI	PVIFLDLNAD	DFSSQDNLDD	PEAGGWDATL
TGEEEEEFFE	LQIVKQHDGE	VKAEASWDSA	VHGCPQLSRG	TPVDERLFLI
VRVTVQLSHP	ADMQLVLRKR	ICVNVHGRQG	FAQSLLKKMS	HRSSIPGCGV
TFEIVSNIPE	DAQGVEEREA	LARMAANVEN	PASADSEAYI	EKYLRSVLAV
ENLLTLDRLR	QEVAVKEQLT	GKGKLSRRSI	SSPNVNRLSG	SRQDLIPSYS
LGSNKGRWES	QQDVSQTTVS	RGIAPAPALS	VSPQNNHSPD	PGLSNLAASY
LNPVKSFVPQ	MPKLLKSLFP	VRDEKRGKRP	SPLAHQPVPR	IMVQSASPDI
RVTRMEEAQP	EMGPDVLVQT	MGAPALKICD	KPAKVPSPPP	VIAVTAVTPA
PEAQDGPPSP	LSEASSGYFS	HSVSTATLSD	ALGPGLDAAA	PPGSMPTAPE
AEPEAPISHP	PPPTAVPAEE	PPGPQQLVSP	GRERPDLEAP	APGSPFRVRR
VRASELRSFS	RMLAGDPGCS	PGAEGNAPAP	GAGGQALASD	SEEADEVPEW
LREGEFVTVG	AHKTGVVRYV	GPADFQEGTW	VGVELDLPSG	KNDGSIGGKQ
YFRCNPGYGL	LVRPSRVRRA	TGPVRRRSTG	LRLGAPEARR	SATLSGSATN
LASLTAALAK	ADRSHKNPEN	RKSWAS

Reference uredi

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000197892 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000060012 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Kinesin family member 13B". Pristupljeno 1. 9. 2016.
^ "UniProt, Q9NQT8" (jezik: engleski). Pristupljeno 19. 9. 2021.

Dopunska literatura uredi

Horiguchi K, Hanada T, Fukui Y, Chishti AH (2006). "Transport of PIP3 by GAKIN, a kinesin-3 family protein, regulates neuronal cell polarity". J. Cell Biol. 174 (3): 425–36. doi:10.1083/jcb.200604031. PMC 2064238. PMID 16864656.

Vanjski linkovi uredi

PDBe-KB provides an overview of all the structure information available in the PDB for Human Kinesin-like protein KIF13B

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000197892 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000060012 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Kinesin family member 13B". Pristupljeno 1. 9. 2016.

[UniProt-6] "UniProt, Q9NQT8" (jezik: engleski). Pristupljeno 19. 9. 2021.

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