TRIL

TRIL
Identifikatori
Aliasi	TRIL
Vanjski ID-jevi	OMIM: 613356 MGI: 1914123 HomoloGene: 69404 GeneCards: TRIL
Lokacija gena (čovjek)
Hrom.	Hromosom 7 (čovjek)
Kraj	28,958,330 bp
Lokacija gena (miš)
Hrom.	Hromosom 6 (miš)
Kraj	53,797,815 bp
Ontologija gena
Molekularna funkcija	• lipopolysaccharide binding;
Ćelijska komponenta	• integral component of membrane; • lipopolysaccharide receptor complex; • membrana; • Vanćelijsko; • GO:0005578 Vanćelijski matriks;
Biološki proces	• regulation of cytokine production involved in immune response; • Urođeni imunski sistem; • inflammatory response; • toll-like receptor 4 signaling pathway; • immune system process;
	Izvori:Amigo / QuickGO
Ortolozi
	9865
	66873
	ENSG00000255690
	ENSMUSG00000043496
	Q7L0X0
	Q9DBY4
	NM_014817
	NM_025817
	NP_055632
	NP_080093
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

KIAA0644, znan i kao TRIL ili interaktor TLR4 sa leucinski bogatim ponavljanjima, jest protein koji je kod ljudi kodiran genom KIAA0644.^[5]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 811 aminokiselina, а molekulska težina 88.723 Da.^[6] Sastoji se prvenstveno od ostataka leucina (17%), alanina i arginina (~ 10%) i glicina (~ 8,5%). Predviđa se da se proteinska sekvenca sastoji uglavnom od α-heliksa i nekoliko β-listova

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MEAARALRLL	LVVCGCLALP	PLAEPVCPER	CDCQHPQHLL	CTNRGLRVVP
KTSSLPSPHD	VLTYSLGGNF	ITNITAFDFH	RLGQLRRLDL	QYNQIRSLHP
KTFEKLSRLE	ELYLGNNLLQ	ALAPGTLAPL	RKLRILYANG	NEISRLSRGS
FEGLESLVKL	RLDGNALGAL	PDAVFAPLGN	LLYLHLESNR	IRFLGKNAFA
QLGKLRFLNL	SANELQPSLR	HAATFAPLRS	LSSLILSANN	LQHLGPRIFQ
HLPRLGLLSL	RGNQLTHLAP	EAFWGLEALR	ELRLEGNRLS	QLPTALLEPL
HSLEALDLSG	NELSALHPAT	FGHLGRLREL	SLRNNALSAL	SGDIFAASPA
LYRLDLDGNG	WTCDCRLRGL	KRWMGDWHSQ	GRLLTVFVQC	RHPPALRGKY
LDYLDDQQLQ	NGSCADPSPS	ASLTADRRRQ	PLPTAAGEEM	TPPAGLAEEL
PPQPQLQQQG	RFLAGVAWDG	AARELVGNRS	ALRLSRRGPG	LQQPSPSVAA
AAGPAPQSLD	LHKKPQRGRP	TRADPALAEP	TPTASPGSAP	SPAGDPWQRA
TKHRLGTEHQ	ERAAQSDGGA	GLPPLVSDPC	DFNKFILCNL	TVEAVGADSA
SVRWAVREHR	SPRPLGGARF	RLLFDRFGQQ	PKFHRFVYLP	ESSDSATLRE
LRGDTPYLVC	VEGVLGGRVC	PVAPRDHCAG	LVTLPEAGSR	GGVDYQLLTL
ALLTVNALLV	LLALAAWASR	WLRRKLRARR	KGGAPVHVRH	MYSTRRPLRS
MGTGVSADFS	GFQSHRPRTT	VCALSEADLI	EFPCDRFMDS	AGGGAGGSLR
REDRLLQRFA	D

Gensko susjedstvo

Gen KIAA0644 susjedi je sa genom za vezanje elemenata koji reagiraju na iRNK–cAMP nizvodno i genom za karboksipeptidaznu iRNK i serin-karboksipeptidazu uzvodno.^[7]^[8]

Funkcija

Tačna funkcija KIAA0644 nije poznata. Međutim, član je porodice proteina leucinom bogatog ponavljanja, za koje je poznato da su uključeni u interakcije protein-protein. Poznato je da ovaj protein stupa u interakciju s proteinom TLR4.

TRIL je komponenta kompleksa TLR4 i u brojnim tipovima ćelija induciran je lipopolisaharidom (LPS).^[9]

Homologija

KIAA0644 dobro je konzerviran među sisarima, ali se može naći u svim hordatima s nižim identitetom sekvence.

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000255690 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000043496 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: TRIL TLR4 interactor with leucine rich repeats". Pristupljeno 13. 5. 2010.
^ "UniProt, Q7L0X0" (jezik: engleski). Pristupljeno 29. 9. 2021.
^ "NCBI Entrez". Pristupljeno 13. 5. 2010.
^ Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (juni 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–176. doi:10.1093/dnares/5.3.169. PMID 9734811.
^ Carpenter S, Carlson T, Dellacasagrande J, Garcia A, Gibbons S, Hertzog P, Lyons A, Lin LL, Lynch M, Monie T, Murphy C, Seidl KJ, Wells C, Dunne A, O'Neill LA (septembar 2009). "TRIL, a functional component of the TLR4 signaling complex, highly expressed in brain". J. Immunol. 183 (6): 3989–3995. doi:10.4049/jimmunol.0901518. PMID 19710467.

Dopunska literatura

Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human Chromosome 7: DNA Sequence and Biology". Science. 300 (5620): 767–772. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
Büssow K, Cahill D, Nietfeld W, et al. (1998). "A method for global protein expression and antibody screening on high-density filters of an arrayed cDNA library". Nucleic Acids Res. 26 (21): 5007–5008. doi:10.1093/nar/26.21.5007. PMC 147919. PMID 9776767.
Wheeler HE, Metter EJ, Tanaka T, et al. (2009). Gibson G (ured.). "Sequential Use of Transcriptional Profiling, Expression Quantitative Trait Mapping, and Gene Association Implicates MMP20 in Human Kidney Aging". PLOS Genet. 5 (10): e1000685. doi:10.1371/journal.pgen.1000685. PMC 2752811. PMID 19834535.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000255690 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000043496 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: TRIL TLR4 interactor with leucine rich repeats". Pristupljeno 13. 5. 2010.

[UniProt-6] "UniProt, Q7L0X0" (jezik: engleski). Pristupljeno 29. 9. 2021.

[Gene_Neighborhood-7] "NCBI Entrez". Pristupljeno 13. 5. 2010.

[pmid9734811-8] Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (juni 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–176. doi:10.1093/dnares/5.3.169. PMID 9734811.

[pmid19710467-9] Carpenter S, Carlson T, Dellacasagrande J, Garcia A, Gibbons S, Hertzog P, Lyons A, Lin LL, Lynch M, Monie T, Murphy C, Seidl KJ, Wells C, Dunne A, O'Neill LA (septembar 2009). "TRIL, a functional component of the TLR4 signaling complex, highly expressed in brain". J. Immunol. 183 (6): 3989–3995. doi:10.4049/jimmunol.0901518. PMID 19710467.

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