IFITM2

IFITM2
Identifikatori
Aliasi	IFITM2
Vanjski ID-jevi	OMIM: 605578 MGI: 1933382 HomoloGene: 74574 GeneCards: IFITM2
Lokacija gena (čovjek)
Hrom.	Hromosom 11 (čovjek)
Kraj	309,397 bp
Lokacija gena (miš)
Hrom.	Hromosom 7 (miš)
Kraj	140,535,900 bp
Ortolozi
	10581
	80876
	ENSG00000185201
	ENSMUSG00000060591
	Q01629
	Q99J93
	NM_006435
	NM_030694
	NP_006426
	NP_109619
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Interferon-inducirani transmembranski protein 2 je protein koji je kod ljudi kodiran genom IFITM2.^[5] IFITM1 je član porodice IFITM (transmembranski protein induciran interferonom) koji je kodiran genima IFITM.

Kao što naziv implicira, ovi geni su inducirani interferonom i čine dio njegovog signalnog puta. U nedostatku stimulacije interferonom, IFITM proteini se mogu široko eksprimirati u tkivima i ćelijskim linijama. Kod ljudi, IFITM1, IFITM2 i IFITM3 mogu se eksprimirati u različitim tkivima i ćelijama, dok je ekspresija IFITM5 ograničena na osteoblaste.^[6]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 132 aminokiseline, a molekulska težina 14.632 Da.^[7]

10	20	30	40	50
MNHIVQTFSP	VNSGQPPNYE	MLKEEQEVAM	LGVPHNPAPP	MSTVIHIRSE
TSVPDHVVWS	LFNTLFMNTC	CLGFIAFAYS	VKSRDRKMVG	DVTGAQAYAS
TAKCLNIWAL	ILGIFMTILL	IIIPVLVVQA	QR

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

Antivirusna funkcija

IFITM-ski proteini identificirani su kao antivirusni restrikcijski faktori koji blokiraju rane faze replikacije virusa.^[8] Inhibiraju replikaciju virusa gripe A,^[9] i infekcija sa širokim spektrom drugih omotanih virusa.^[10]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000185201 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000060591 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Interferon induced transmembrane protein 2". Pristupljeno 21. 2. 2016.
^ Tanaka SS, Yamaguchi YL, Tsoi B, Lickert H, Tam PP (decembar 2005). "IFITM/Mil/fragilis family proteins IFITM1 and IFITM3 play distinct roles in mouse primordial germ cell homing and repulsion". Dev. Cell. 9 (6): 745–56. doi:10.1016/j.devcel.2005.10.010. PMID 16326387.
^ "UniProt, Q01629". Pristupljeno 23. 8. 2021.
^ Li K, Markosyan RM, Zheng YM, Golfetto O, Bungart B, Li M, Ding S, He Y, Liang C, Lee JC, Gratton E, Cohen FS, Liu SL (januar 2013). "IFITM proteins restrict viral membrane hemifusion". PLOS Pathog. 9 (1): e1003124. doi:10.1371/journal.ppat.1003124. PMC 3554583. PMID 23358889.
^ Feeley EM, Sims JS, John SP, Chin CR, Pertel T, Chen LM, Gaiha GD, Ryan BJ, Donis RO, Elledge SJ, Brass AL (oktobar 2011). "IFITM3 inhibits influenza A virus infection by preventing cytosolic entry". PLOS Pathog. 7 (10): e1002337. doi:10.1371/journal.ppat.1002337. PMC 3203188. PMID 22046135.
^ Brass AL, Huang IC, Benita Y, John SP, Krishnan MN, Feeley EM, Ryan BJ, Weyer JL, van der Weyden L, Fikrig E, Adams DJ, Xavier RJ, Farzan M, Elledge SJ (decembar 2009). "The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus". Cell. 139 (7): 1243–54. doi:10.1016/j.cell.2009.12.017. PMC 2824905. PMID 20064371.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000185201 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000060591 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Interferon induced transmembrane protein 2". Pristupljeno 21. 2. 2016.

[pmid16326387-6] Tanaka SS, Yamaguchi YL, Tsoi B, Lickert H, Tam PP (decembar 2005). "IFITM/Mil/fragilis family proteins IFITM1 and IFITM3 play distinct roles in mouse primordial germ cell homing and repulsion". Dev. Cell. 9 (6): 745–56. doi:10.1016/j.devcel.2005.10.010. PMID 16326387.

[UniProt-7] "UniProt, Q01629". Pristupljeno 23. 8. 2021.

[pmid23358889-8] Li K, Markosyan RM, Zheng YM, Golfetto O, Bungart B, Li M, Ding S, He Y, Liang C, Lee JC, Gratton E, Cohen FS, Liu SL (januar 2013). "IFITM proteins restrict viral membrane hemifusion". PLOS Pathog. 9 (1): e1003124. doi:10.1371/journal.ppat.1003124. PMC 3554583. PMID 23358889.

[pmid22046135-9] Feeley EM, Sims JS, John SP, Chin CR, Pertel T, Chen LM, Gaiha GD, Ryan BJ, Donis RO, Elledge SJ, Brass AL (oktobar 2011). "IFITM3 inhibits influenza A virus infection by preventing cytosolic entry". PLOS Pathog. 7 (10): e1002337. doi:10.1371/journal.ppat.1002337. PMC 3203188. PMID 22046135.

[pmid20064371-10] Brass AL, Huang IC, Benita Y, John SP, Krishnan MN, Feeley EM, Ryan BJ, Weyer JL, van der Weyden L, Fikrig E, Adams DJ, Xavier RJ, Farzan M, Elledge SJ (decembar 2009). "The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus". Cell. 139 (7): 1243–54. doi:10.1016/j.cell.2009.12.017. PMC 2824905. PMID 20064371.

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