HRC
Histidinom bogati kalcij-vezujući protein sarkoplazmatskog retikuluma je protein koji je kod ljudi kodiran genom HRC.[3][4]
Aminokiselinska sekvenca uredi
- Simboli
C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MGHHRPWLHA | SVLWAGVASL | LLPPAMTQQL | RGDGLGFRNR | NNSTGVAGLS | ||||
| EEASAELRHH | LHSPRDHPDE | NKDVSTENGH | HFWSHPDREK | EDEDVSKEYG | ||||
| HLLPGHRSQD | HKVGDEGVSG | EEVFAEHGGQ | ARGHRGHGSE | DTEDSAEHRH | ||||
| HLPSHRSHSH | QDEDEDEVVS | SEHHHHILRH | GHRGHDGEDD | EGEEEEEEEE | ||||
| EEEEASTEYG | HQAHRHRGHG | SEEDEDVSDG | HHHHGPSHRH | QGHEEDDDDD | ||||
| DDDDDDDDDD | DVSIEYRHQA | HRHQGHGIEE | DEDVSDGHHH | RDPSHRHRSH | ||||
| EEDDNDDDDV | STEYGHQAHR | HQDHRKEEVE | AVSGEHHHHV | PDHRHQGHRD | ||||
| EEEDEDVSTE | RWHQGPQHVH | HGLVDEEEEE | EEITVQFGHY | VASHQPRGHK | ||||
| SDEEDFQDEY | KTEVPHHHHH | RVPREEDEEV | SAELGHQAPS | HRQSHQDEET | ||||
| GHGQRGSIKE | MSHHPPGHTV | VKDRSHLRKD | DSEEEKEKEE | DPGSHEEDDE | ||||
| SSEQGEKGTH | HGSRDQEDEE | DEEEGHGLSL | NQEEEEEEDK | EEEEEEEDEE | ||||
| RREERAEVGA | PLSPDHSEEE | EEEEEGLEED | EPRFTIIPNP | LDRREEAGGA | ||||
| SSEEESGEDT | GPQDAQEYGN | YQPGSLCGYC | SFCNRCTECE | SCHCDEENMG | ||||
| EHCDQCQHCQ | FCYLCPLVCE | TVCAPGSYVD | YFSSSLYQAL | ADMLETPEP |
Funkcija uredi
Protein koji veže kalcijem bogati histidin je luminalni protein sarkoplazmatskog retikuluma od 165 kD, prepoznatljiv po svojoj sposobnosti da veže lipoprotein male gustoće, sa visokim afinitetom.[4]
Reference uredi
- ^ a b c GRCh38: Ensembl release 89: ENSG00000130528 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Hofmann SL, Topham M, Hsieh CL, Francke U (Apr 1991). "cDNA and genomic cloning of HRC, a human sarcoplasmic reticulum protein, and localization of the gene to human chromosome 19 and mouse chromosome 7". Genomics. 9 (4): 656–69. doi:10.1016/0888-7543(91)90359-M. PMID 2037293.
- ^ a b "Entrez Gene: HRC histidine rich calcium binding protein".
Dopunska literatura uredi
- Anderson NL, Anderson NG (Nov 2002). "The human plasma proteome: history, character, and diagnostic prospects". Molecular & Cellular Proteomics. 1 (11): 845–67. doi:10.1074/mcp.R200007-MCP200. PMID 12488461.
- Hofmann SL, Brown MS, Lee E, Pathak RK, Anderson RG, Goldstein JL (maj 1989). "Purification of a sarcoplasmic reticulum protein that binds Ca2+ and plasma lipoproteins". The Journal of Biological Chemistry. 264 (14): 8260–70. PMID 2498310.
- Ridgeway AG, Petropoulos H, Siu A, Ball JK, Skerjanc IS (Aug 1999). "Cloning, tissue distribution, subcellular localization and overexpression of murine histidine-rich Ca2+ binding protein". FEBS Letters. 456 (3): 399–402. doi:10.1016/S0014-5793(99)00993-X. PMID 10462052. S2CID 19920072.
- Lee HG, Kang H, Kim DH, Park WJ (Oct 2001). "Interaction of HRC (histidine-rich Ca(2+)-binding protein) and triadin in the lumen of sarcoplasmic reticulum". The Journal of Biological Chemistry. 276 (43): 39533–8. doi:10.1074/jbc.M010664200. PMID 11504710.
- Sacchetto R, Damiani E, Turcato F, Nori A, Margreth A (Dec 2001). "Ca(2+)-dependent interaction of triadin with histidine-rich Ca(2+)-binding protein carboxyl-terminal region". Biochemical and Biophysical Research Communications. 289 (5): 1125–34. doi:10.1006/bbrc.2001.6126. PMID 11741309.
- Kim E, Shin DW, Hong CS, Jeong D, Kim DH, Park WJ (Jan 2003). "Increased Ca2+ storage capacity in the sarcoplasmic reticulum by overexpression of HRC (histidine-rich Ca2+ binding protein)". Biochemical and Biophysical Research Communications. 300 (1): 192–6. doi:10.1016/S0006-291X(02)02829-2. PMID 12480542.
- Adkins JN, Varnum SM, Auberry KJ, Moore RJ, Angell NH, Smith RD, Springer DL, Pounds JG (Dec 2002). "Toward a human blood serum proteome: analysis by multidimensional separation coupled with mass spectrometry". Molecular & Cellular Proteomics. 1 (12): 947–55. doi:10.1074/mcp.M200066-MCP200. PMID 12543931.
- Anderson JP, Dodou E, Heidt AB, De Val SJ, Jaehnig EJ, Greene SB, Olson EN, Black BL (maj 2004). "HRC is a direct transcriptional target of MEF2 during cardiac, skeletal, and arterial smooth muscle development in vivo". Molecular and Cellular Biology. 24 (9): 3757–68. doi:10.1128/MCB.24.9.3757-3768.2004. PMC 387749. PMID 15082771.
- Fan GC, Gregory KN, Zhao W, Park WJ, Kranias EG (Oct 2004). "Regulation of myocardial function by histidine-rich, calcium-binding protein". American Journal of Physiology. Heart and Circulatory Physiology. 287 (4): H1705–11. doi:10.1152/ajpheart.01211.2003. PMID 15191886. S2CID 15011211.
- Arvanitis DA, Vafiadaki E, Fan GC, Mitton BA, Gregory KN, Del Monte F, Kontrogianni-Konstantopoulos A, Sanoudou D, Kranias EG (Sep 2007). "Histidine-rich Ca-binding protein interacts with sarcoplasmic reticulum Ca-ATPase". American Journal of Physiology. Heart and Circulatory Physiology. 293 (3): H1581–9. doi:10.1152/ajpheart.00278.2007. PMID 17526652.
- Singh VP, Rubinstein J, Arvanitis DA, Ren X, Gao X, Haghighi K, Gilbert M, Iyer VR, Kim DH, Cho C, Jones K, Lorenz JN, Armstrong CF, Wang HS, Gyorke S, Kranias EG (2013). "Abnormal calcium cycling and cardiac arrhythmias associated with the human Ser96Ala genetic variant of histidine-rich calcium-binding protein". Journal of the American Heart Association. 2 (5): e000460. doi:10.1161/JAHA.113.000460. PMC 3835262. PMID 24125847.