HIST1H4G

HIST1H4G
Identifikatori
Aliasi	H4C7
Vanjski ID-jevi	OMIM: 602832 HomoloGene: 48222 GeneCards: H4C7
Lokacija gena (čovjek)
Hrom.	Hromosom 6 (čovjek)
Kraj	26,246,996 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine; • protein heterodimerization activity; • vezivanje sa DNK; • GO:0031493 histone binding; • molekularna funkcija;
Ćelijska komponenta	• Nukleosom; • jedro; • hromosom;
Biološki proces	• nucleosome assembly; • GO:0022610 biološki proces;
	Izvori:Amigo / QuickGO
Ortolozi
	8369
	n/a
	ENSG00000275663
	n/a
	Q99525
	n/a
	NM_003547
	n/a
	NP_003538
	n/a
	Wikipodaci
Pogledaj/uredi – čovjek

H4-liki histon jest protein koji je kod ljudi kodiran genom HIST1H4G sa hromosoma 6.^[3]^[4]^[5]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 98 aminokiselina, a molekulska težina 11.009 Da.^[5]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10		20		30		40		50
MSVRGKAGKG		LGKGGAKCHR		KVLSDNIQGI		TKCTIRRLAR		HGGVKRILGL
IYEETRRVFK		VFLENVIWYA		VTNTEHAKRK		TVTAMAVVYV		LKRQGRTL

Funkcija

Histoni su osnovni jedarni proteini koji su odgovorni za nukleosomsku strukturu hromosomskog vlakna kod eukariota. Dvije molekule svakog od četiri jezgarna histona (H2A, H2B, H3 i H4) formiraju oktamer, oko kojeg je omotano oko 146 bp DNK u ponavljajuće jedinice, zvane nukleosomi. Linkerski histon, H1, stupa u interakciju s DNK-linkera između nukleosoma i funkcionira u zbijanju hromatina u strukture višeg reda. Ovaj gen je bez introna i kodira člana porodice histona H4. Transkripti ovog gena nemaju poliA repove, ali umjesto toga sadrže palindromski terminacijski element. Ovaj gen nalazi se u velikom klasteru histonskih gena na hromosomu 6.^[5]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000275663 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Albig W, Kioschis P, Poustka A, Meergans K, Doenecke D (Apr 1997). "Human histone gene organization: nonregular arrangement within a large cluster". Genomics. 40 (2): 314–22. doi:10.1006/geno.1996.4592. PMID 9119399.
^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.
^ ^a ^b ^c "Entrez Gene: HIST1H4G histone cluster 1, H4g".

Dopunska literatura

Lusic M, Marcello A, Cereseto A, Giacca M (2004). "Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter". EMBO J. 22 (24): 6550–61. doi:10.1093/emboj/cdg631. PMC 291826. PMID 14657027.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Deng L, Wang D, de la Fuente C, et al. (2001). "Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA". Virology. 289 (2): 312–26. doi:10.1006/viro.2001.1129. PMID 11689053.
Deng L, de la Fuente C, Fu P, et al. (2001). "Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones". Virology. 277 (2): 278–95. doi:10.1006/viro.2000.0593. PMID 11080476.
El Kharroubi A, Piras G, Zensen R, Martin MA (1998). "Transcriptional Activation of the Integrated Chromatin-Associated Human Immunodeficiency Virus Type 1 Promoter". Mol. Cell. Biol. 18 (5): 2535–44. doi:10.1128/mcb.18.5.2535. PMC 110633. PMID 9566873.
Albig W, Doenecke D (1998). "The human histone gene cluster at the D6S105 locus". Hum. Genet. 101 (3): 284–94. doi:10.1007/s004390050630. PMID 9439656. S2CID 38539096.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000275663 - Ensembl, maj 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9119399-3] Albig W, Kioschis P, Poustka A, Meergans K, Doenecke D (Apr 1997). "Human histone gene organization: nonregular arrangement within a large cluster". Genomics. 40 (2): 314–22. doi:10.1006/geno.1996.4592. PMID 9119399.

[pmid12408966-4] Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.

[entrez-5] "Entrez Gene: HIST1H4G histone cluster 1, H4g".

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