Histon H4 jest protein koji je kod ljudi kodiran genom HIST1H4F sa hromosoma 6.[5][6][7][8]

HIST1H4F
Dostupne strukture
PDBPretraga ortologa: PDBe RCSB
Spisak PDB ID kodova

4H9O, 3WKJ, 3AYW, 3WA9, 5B0Z, 5AVB, 2CV5, 5AV5, 3AV2, 3WTP, 3AV1, 3AZK, 3X1V, 5AV8, 1F66, 4QUU, 3CFS, 4YYK, 4QUT, 3NQJ, 3A6N, 3W99, 5AVC, 2RS9, 3F9Z, 3QZT, 3QBY, 3W97, 4M38, 4YM6, 3CFV, 4HGA, 1EQZ, 2RJE, 3QZV, 1HQ3, 4H9P, 3AZL, 3AFA, 1TZY, 3UVY, 5CPK, 3JPX, 4U9W, 4N3W, 4YYJ, 4YYD, 4H9N, 4H9R, 3AZI, 4LD9, 3UVX, 3AZH, 5BNX, 4N4F, 1U35, 4YYG, 3O36, 2ARO, 5AV9, 4H9S, 3AZF, 3W98, 4GQB, 4H9Q, 5BNV, 3WAA, 3AZG, 3AZE, 2RNY, 1ZKK, 2QQS, 2LVM, 3X1T, 3AN2, 2KWO, 3QZS, 3F9W, 5FFW, 5CPJ, 3F9X, 3IJ1, 4YM5, 3AZJ, 4YY6, 3AZN, 2IG0, 4YYH, 4YYI, 5CPI, 3W96, 3R45, 2KWN, 3F9Y, 5AV6, 3AZM, 5BO0, 3X1S, 4QYD, 4KGC, 3UVW, 4YYN, 3X1U, 3UW9, 2F8N, 3NQU, 5B0Y, 4YYM, 5C3I, 4Z5T, 5B24, 5FA5, 4Z2M, 5E5A, 5FWE, 5B2I, 5B40, 5B2J, 5JA4, 5AY8, 4ZUX

Identifikatori
AliasiH4C6
Vanjski ID-jeviOMIM: 602824 MGI: 2448421 HomoloGene: 136776 GeneCards: H4C6
Lokacija gena (čovjek)
Hromosom 6 (čovjek)
Hrom.Hromosom 6 (čovjek)[1]
Hromosom 6 (čovjek)
Genomska lokacija za HIST1H4F
Genomska lokacija za HIST1H4F
Bend6p22.2Početak26,240,393 bp[1]
Kraj26,240,793 bp[1]
Lokacija gena (miš)
Hromosom 13 (miš)
Hrom.Hromosom 13 (miš)[2]
Hromosom 13 (miš)
Genomska lokacija za HIST1H4F
Genomska lokacija za HIST1H4F
Bend13|13 A3.1Početak23,881,618 bp[2]
Kraj23,882,437 bp[2]
Ontologija gena
Molekularna funkcija protein domain specific binding
GO:0001948, GO:0016582 vezivanje za proteine
protein heterodimerization activity
vezivanje sa DNK
GO:0031493 histone binding
vezivanje sa RNK
Ćelijska komponenta membrana
hromosom
nukleoplazma
extracellular region
nuclear chromosome
Nukleosom
Egzosom
jedro
GO:0005578 Vanćelijski matriks
GO:0009327 makromolekulani kompleks
Biološki proces telomere organization
epigenetic maintenance of chromatin in transcription-competent conformation
protein heterotetramerization
negative regulation of megakaryocyte differentiation
GO:0061641 CENP-A containing chromatin assembly
GO:0034723 DNA replication-dependent chromatin assembly
rDNA heterochromatin assembly
negative regulation of gene expression, epigenetic
DNA-templated transcription, initiation
double-strand break repair via nonhomologous end joining
beta-catenin-TCF complex assembly
telomere capping
nucleosome assembly
GO:1905616 regulation of gene silencing by miRNA
regulation of megakaryocyte differentiation
regulation of hematopoietic stem cell differentiation
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_003540

NM_178208

RefSeq (bjelančevina)
NP_003537
NP_003486
NP_003535
NP_003539
NP_003531

NP_003536

NP_291074
NP_783587
NP_783588
NP_835499
NP_835500

NP_001182350
NP_835515
NP_783585
NP_783586
NP_835582
NP_835583
NP_783583
NP_694813

Lokacija (UCSC)Chr 6: 26.24 – 26.24 MbChr 13: 23.88 – 23.88 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Aminokiselinska sekvenca

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Dužina polipeptidnog lanca je 103 aminokiseline, a molekulska težina 11.367 Da.[8]

1020304050
MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGL
IYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYG
FGG

Funkcija

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Histoni su osnovni jedarni proteini koji su odgovorni za nukleosomsku strukturu hromosomskog vlakna kod eukariota. Dvije molekule svakog od četiri jezgarna histona (H2A, H2B, H3 i H4) formiraju oktamer, oko kojeg je omotano oko 146 bp DNK u ponavljajuće jedinice, zvane nukleosomi. Linkerski histon, H1, stupa u interakciju s DNK-linkera između nukleosoma i funkcionira u zbijanju hromatina u strukture višeg reda. Ovaj gen je bez introna i kodira člana porodice histona H4. Transkripti ovog gena nemaju poliA repove, ali umjesto toga sadrže palindromski terminacijski element. Ovaj gen nalazi se u velikom klasteru histonskih gena na hromosomu 6.[8]

Reference

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000274618 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000060678 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Albig W, Kardalinou E, Drabent B, Zimmer A, Doenecke D (Nov 1991). "Isolation and characterization of two human H1 histone genes within clusters of core histone genes". Genomics. 10 (4): 940–8. doi:10.1016/0888-7543(91)90183-F. PMID 1916825.
  6. ^ Albig W, Kioschis P, Poustka A, Meergans K, Doenecke D (Apr 1997). "Human histone gene organization: nonregular arrangement within a large cluster". Genomics. 40 (2): 314–22. doi:10.1006/geno.1996.4592. PMID 9119399.
  7. ^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.
  8. ^ a b c "Entrez Gene: HIST1H4F histone cluster 1, H4f".

Dopunska literatura

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Vanjski linkovi

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