HIST1H4C

Histon H4 jest protein koji je kod ljudi kodiran genom HIST1H4C sa hromosoma 6.

HIST1H4C
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 4H9O, 3WKJ, 3AYW, 3WA9, 5B0Z, 5AVB, 2CV5, 5AV5, 3AV2, 3WTP, 3AV1, 3AZK, 3X1V, 5AV8, 1F66, 4QUU, 3CFS, 4YYK, 4QUT, 3NQJ, 3A6N, 3W99, 5AVC, 2RS9, 3F9Z, 3QZT, 3QBY, 3W97, 4M38, 4YM6, 3CFV, 4HGA, 1EQZ, 2RJE, 3QZV, 1HQ3, 4H9P, 3AZL, 3AFA, 1TZY, 3UVY, 5CPK, 3JPX, 4U9W, 4N3W, 4YYJ, 4YYD, 4H9N, 4H9R, 3AZI, 4LD9, 3UVX, 3AZH, 5BNX, 4N4F, 1U35, 4YYG, 3O36, 2ARO, 5AV9, 4H9S, 3AZF, 3W98, 4GQB, 4H9Q, 5BNV, 3WAA, 3AZG, 3AZE, 2RNY, 1ZKK, 2QQS, 2LVM, 3X1T, 3AN2, 2KWO, 3QZS, 3F9W, 5FFW, 5CPJ, 3F9X, 3IJ1, 4YM5, 3AZJ, 4YY6, 3AZN, 2IG0, 4YYH, 4YYI, 5CPI, 3W96, 3R45, 2KWN, 3F9Y, 5AV6, 3AZM, 5BO0, 3X1S, 4QYD, 4KGC, 3UVW, 4YYN, 3X1U, 3UW9, 2F8N, 3NQU, 5B0Y, 4YYM, 5C3I, 4Z5T, 5B24, 5FA5, 4Z2M, 5E5A, 5FWE, 5B2I, 5B40, 5B2J, 5JA4, 5AY8, 4ZUX
Identifikatori
Aliasi	H4C3
Vanjski ID-jevi	OMIM: 602827 MGI: 2140113 HomoloGene: 134234 GeneCards: H4C3
Lokacija gena (čovjek) Hrom. Hromosom 6 (čovjek) Bend 6p22.2 Početak 26,103,933 bp Kraj 26,104,337 bp
Lokacija gena (miš) Hrom. Hromosom 3 (miš) Bend 3|3 F2.1 Početak 96,168,998 bp Kraj 96,170,627 bp
Ontologija gena Molekularna funkcija • protein domain specific binding • GO:0001948, GO:0016582 vezivanje za proteine • protein heterodimerization activity • vezivanje sa DNK • GO:0031493 histone binding • vezivanje sa RNK Ćelijska komponenta • membrana • hromosom • nukleoplazma • extracellular region • nuclear chromosome • Nukleosom • Egzosom • jedro • GO:0005578 Vanćelijski matriks • GO:0009327 makromolekulani kompleks Biološki proces • telomere organization • epigenetic maintenance of chromatin in transcription-competent conformation • protein heterotetramerization • negative regulation of megakaryocyte differentiation • GO:0061641 CENP-A containing chromatin assembly • GO:0034723 DNA replication-dependent chromatin assembly • rDNA heterochromatin assembly • negative regulation of gene expression, epigenetic • DNA-templated transcription, initiation • double-strand break repair via nonhomologous end joining • beta-catenin-TCF complex assembly • telomere capping • nucleosome assembly • GO:1905616 regulation of gene silencing by miRNA • regulation of megakaryocyte differentiation • regulation of hematopoietic stem cell differentiation Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	8364	97122
Ensembl	ENSG00000197061	ENSMUSG00000091405
UniProt	P62805	P62806
RefSeq (mRNK)	NM_003542	NM_033596
RefSeq (bjelančevina)	NP_003537 NP_003486 NP_003535 NP_003539 NP_003531 NP_003536	NP_291074 NP_783587 NP_783588 NP_835499 NP_835500 NP_001182350 NP_835515 NP_783585 NP_783586 NP_835582 NP_835583 NP_783583 NP_694813
Lokacija (UCSC)	Chr 6: 26.1 – 26.1 Mb	Chr 3: 96.17 – 96.17 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 103 aminokiseline, a molekulska težina 11.367 Da.

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MSGRGKGGKG		LGKGGAKRHR		KVLRDNIQGI		TKPAIRRLAR		RGGVKRISGL
IYEETRGVLK		VFLENVIRDA		VTYTEHAKRK		TVTAMDVVYA		LKRQGRTLYG
FGG

Funkcija

Histoni su osnovni jedarni proteini koji su odgovorni za nukleosomsku strukturu hromosomskog vlakna kod eukariota. Dvije molekule svakog od četiri histonska jezgra (H2A, H2B, H3 i H4) formiraju oktamer, oko kojeg je omotano oko 146 bp DNK u ponavljajuće jedinice, zvane nukleosomi. Linkerski histon, H1, stupa u interakciju sa linkerom DNK između nukleosoma i funkcionira u zbijanju hromatina u strukture višeg reda. Ovaj gen je bez introna i kodira člana porodice histona H4. Transkripti ovog gena nemaju poliA repove, ali umjesto toga sadrže palindromski terminacijski element. Ovaj gen se nalazi u velikom klasteru histonskih gena na hromosomu 6.

Dopunska literatura

• Drabent B, Kardalinou E, Bode C, Doenecke D (1995). "Association of histone H4 genes with the mammalian testis-specific H1t histone gene". DNA Cell Biol. 14 (7): 591–7. doi:10.1089/dna.1995.14.591. PMID 7626218.
• Albig W, Doenecke D (1998). "The human histone gene cluster at the D6S105 locus". Hum. Genet. 101 (3): 284–94. doi:10.1007/s004390050630. PMID 9439656. S2CID 38539096.
• El Kharroubi A, Piras G, Zensen R, Martin MA (1998). "Transcriptional activation of the integrated chromatin-associated human immunodeficiency virus type 1 promoter". Mol. Cell. Biol. 18 (5): 2535–44. doi:10.1128/mcb.18.5.2535. PMC 110633. PMID 9566873.
• Deng L, de la Fuente C, Fu P, Wang L, Donnelly R, Wade JD, Lambert P, Li H, Lee CG, Kashanchi F (2001). "Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones". Virology. 277 (2): 278–95. doi:10.1006/viro.2000.0593. PMID 11080476.
• Deng L, Wang D, de la Fuente C, Wang L, Li H, Lee CG, Donnelly R, Wade JD, Lambert P, Kashanchi F (2001). "Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA". Virology. 289 (2): 312–26. doi:10.1006/viro.2001.1129. PMID 11689053.
• Lusic M, Marcello A, Cereseto A, Giacca M (2004). "Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter". EMBO J. 22 (24): 6550–61. doi:10.1093/emboj/cdg631. PMC 291826. PMID 14657027.
• Dickinson LA, Burnett R, Melander C, Edelson BS, Arora PS, Dervan PB, Gottesfeld JM (2005). "Arresting cancer proliferation by small-molecule gene regulation". Chem. Biol. 11 (11): 1583–94. doi:10.1016/j.chembiol.2004.09.004. PMID 15556009.