Histon H4 jest protein koji je kod ljudi kodiran genom HIST1H4B sa hromosoma 6.[5][6][7]

HIST1H4B
Dostupne strukture
PDBPretraga ortologa: PDBe RCSB
Spisak PDB ID kodova

4H9O, 3WKJ, 3AYW, 3WA9, 5B0Z, 5AVB, 2CV5, 5AV5, 3AV2, 3WTP, 3AV1, 3AZK, 3X1V, 5AV8, 1F66, 4QUU, 3CFS, 4YYK, 4QUT, 3NQJ, 3A6N, 3W99, 5AVC, 2RS9, 3F9Z, 3QZT, 3QBY, 3W97, 4M38, 4YM6, 3CFV, 4HGA, 1EQZ, 2RJE, 3QZV, 1HQ3, 4H9P, 3AZL, 3AFA, 1TZY, 3UVY, 5CPK, 3JPX, 4U9W, 4N3W, 4YYJ, 4YYD, 4H9N, 4H9R, 3AZI, 4LD9, 3UVX, 3AZH, 5BNX, 4N4F, 1U35, 4YYG, 3O36, 2ARO, 5AV9, 4H9S, 3AZF, 3W98, 4GQB, 4H9Q, 5BNV, 3WAA, 3AZG, 3AZE, 2RNY, 1ZKK, 2QQS, 2LVM, 3X1T, 3AN2, 2KWO, 3QZS, 3F9W, 5FFW, 5CPJ, 3F9X, 3IJ1, 4YM5, 3AZJ, 4YY6, 3AZN, 2IG0, 4YYH, 4YYI, 5CPI, 3W96, 3R45, 2KWN, 3F9Y, 5AV6, 3AZM, 5BO0, 3X1S, 4QYD, 4KGC, 3UVW, 4YYN, 3X1U, 3UW9, 2F8N, 3NQU, 5B0Y, 4YYM, 5C3I, 4Z5T, 5B24, 5FA5, 4Z2M, 5E5A, 5FWE, 5B2I, 5B40, 5B2J, 5JA4, 5AY8, 4ZUX

Identifikatori
AliasiH4C2
Vanjski ID-jeviOMIM: 602829 MGI: 2448443 HomoloGene: 134493 GeneCards: H4C2
Lokacija gena (čovjek)
Hromosom 6 (čovjek)
Hrom.Hromosom 6 (čovjek)[1]
Hromosom 6 (čovjek)
Genomska lokacija za HIST1H4B
Genomska lokacija za HIST1H4B
Bend6p22.2Početak26,026,896 bp[1]
Kraj26,027,283 bp[1]
Lokacija gena (miš)
Hromosom 6 (miš)
Hrom.Hromosom 6 (miš)[2]
Hromosom 6 (miš)
Genomska lokacija za HIST1H4B
Genomska lokacija za HIST1H4B
Bend6|6 G1Početak136,778,551 bp[2]
Kraj136,781,413 bp[2]
Ontologija gena
Molekularna funkcija protein domain specific binding
GO:0001948, GO:0016582 vezivanje za proteine
protein heterodimerization activity
vezivanje sa DNK
GO:0031493 histone binding
vezivanje sa RNK
Ćelijska komponenta membrana
hromosom
nukleoplazma
extracellular region
nuclear chromosome
Nukleosom
Egzosom
jedro
GO:0005578 Vanćelijski matriks
GO:0009327 makromolekulani kompleks
Biološki proces telomere organization
epigenetic maintenance of chromatin in transcription-competent conformation
protein heterotetramerization
negative regulation of megakaryocyte differentiation
GO:0061641 CENP-A containing chromatin assembly
GO:0034723 DNA replication-dependent chromatin assembly
rDNA heterochromatin assembly
negative regulation of gene expression, epigenetic
DNA-templated transcription, initiation
double-strand break repair via nonhomologous end joining
beta-catenin-TCF complex assembly
telomere capping
nucleosome assembly
GO:1905616 regulation of gene silencing by miRNA
regulation of megakaryocyte differentiation
regulation of hematopoietic stem cell differentiation
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_003544

NM_175652

RefSeq (bjelančevina)
NP_003537
NP_003486
NP_003535
NP_003539
NP_003531

NP_003536

NP_291074
NP_783587
NP_783588
NP_835499
NP_835500

NP_001182350
NP_835515
NP_783585
NP_783586
NP_835582
NP_835583
NP_783583
NP_694813

Lokacija (UCSC)Chr 6: 26.03 – 26.03 MbChr 6: 136.78 – 136.78 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Aminokiselinska sekvenca

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Dužina polipeptidnog lanca je 103 aminokiseline, a molekulska težina 11.367 Da.[7]

1020304050
MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGL
IYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYG
FGG

Funkcija

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Histoni su osnovni jedarni proteini koji su odgovorni za strukturu nukleosoma hromosomskog vlakna u eukariotima. Dvije molekule svakog od četiri jezgra histona (H2A, H2B, H3 i H4) formiraju oktamer, oko kojeg je otprilike 147 bp DNK omotano u ponavljajuće jedinice, zvane nukleosomi. Linkerski histon, H1, stupa u interakciju sa linkerom DNK između nukleosoma i funkcionira u zbijanju hromatina u strukture višeg reda. Ovaj gen je bez introna i kodira člana porodice histona H4. Transkripti ovog gena nemaju poliA repove, ali umjesto toga sadrže palindromski terminacijski element. Ovaj gen nalazi se u velikom klasteru histonskih gena na hromosomu 6.[7]

Reference

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000278705 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000096010 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Albig W, Kioschis P, Poustka A, Meergans K, Doenecke D (Apr 1997). "Human histone gene organization: nonregular arrangement within a large cluster". Genomics. 40 (2): 314–322. doi:10.1006/geno.1996.4592. PMID 9119399.
  6. ^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–498. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.
  7. ^ a b c "Entrez Gene: HIST1H4B histone cluster 1, H4b".

Dopunska literatura

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Vanjski linkovi

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