Hem-vezujući protein 2 jest protein koji je kod ljudi kodiran genom HEBP2.[5][6][7]

HEBP2
Dostupne strukture
PDBPretraga ortologa: PDBe RCSB
Spisak PDB ID kodova

3R85, 3R8J, 3R8K, 4AYZ, 4B0Y

Identifikatori
AliasiHEBP2
Vanjski ID-jeviOMIM: 605825 MGI: 1860084 HomoloGene: 8634 GeneCards: HEBP2
Lokacija gena (čovjek)
Hromosom 6 (čovjek)
Hrom.Hromosom 6 (čovjek)[1]
Hromosom 6 (čovjek)
Genomska lokacija za HEBP2
Genomska lokacija za HEBP2
Bend6q24.1Početak138,403,531 bp[1]
Kraj138,422,197 bp[1]
Lokacija gena (miš)
Hromosom 10 (miš)
Hrom.Hromosom 10 (miš)[2]
Hromosom 10 (miš)
Genomska lokacija za HEBP2
Genomska lokacija za HEBP2
Bend10|10 A3Početak18,415,246 bp[2]
Kraj18,421,824 bp[2]
Obrazac RNK ekspresije
Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija GO:0001948, GO:0016582 vezivanje za proteine
heme binding
Ćelijska komponenta citoplazma
Egzosom
mitohondrija
extracellular region
azurophil granule lumen
Biološki proces negative regulation of mitochondrial membrane potential
positive regulation of necrotic cell death
regulation of response to reactive oxygen species
positive regulation of mitochondrial membrane permeability
neutrophil degranulation
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_014320
NM_001326380
NM_001326381

NM_019487

RefSeq (bjelančevina)

NP_001313309
NP_001313310
NP_055135

NP_062360

Lokacija (UCSC)Chr 6: 138.4 – 138.42 MbChr 10: 18.42 – 18.42 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Aminokiselinska sekvenca

uredi

Dužina polipeptidnog lanca je 205 aminokiselina, а molekulska težina 22.875 Da.[8]

1020304050
MAEPLQPDPGAAEDAAAQAVETPGWKAPEDAGPQPGSYEIRHYGPAKWVS
TSVESMDWDSAIQTGFTKLNSYIQGKNEKEMKIKMTAPVTSYVEPGSGPF
SESTITISLYIPSEQQFDPPRPLESDVFIEDRAEMTVFVRSFDGFSSAQK
NQEQLLTLASILREDGKVFDEKVYYTAGYNSPVKLLNRNNEVWLIQKNEP
TKENE

Reference

uredi
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000051620 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000019853 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Zylka MJ, Reppert SM (Feb 2000). "Discovery of a putative heme-binding protein family (SOUL/HBP) by two-tissue suppression subtractive hybridization and database searches". Brain Res Mol Brain Res. 74 (1–2): 175–81. doi:10.1016/S0169-328X(99)00277-6. PMID 10640688.
  6. ^ Szigeti A, Bellyei S, Gasz B, Boronkai A, Hocsak E, Minik O, Bognar Z, Varbiro G, Sumegi B, Gallyas F Jr (Nov 2006). "Induction of necrotic cell death and mitochondrial permeabilization by heme binding protein 2/SOUL". FEBS Lett. 580 (27): 6447–54. doi:10.1016/j.febslet.2006.10.067. PMID 17098234. S2CID 19675303.
  7. ^ "Entrez Gene: HEBP2 heme binding protein 2".
  8. ^ "UniProt, Q9Y5Z4" (jezik: engleski). Pristupljeno 8. 10. 2021.

Dopunska literatura

uredi