HDGFRP3

Hepatom-izvedeni faktor rasta srodan sa proteinom 3, znan i kao HDGFRP3, je ljudski gen.

HDGFRP3
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 1N27
Identifikatori
Aliasi	HDGFL3
Vanjski ID-jevi	OMIM: 616643 MGI: 1352760 HomoloGene: 32196 GeneCards: HDGFL3
Lokacija gena (čovjek) Hrom. Hromosom 15 (čovjek) Bend 15q25.2 Početak 83,112,738 bp Kraj 83,207,823 bp
Lokacija gena (miš) Hrom. Hromosom 7 (miš) Bend 7|7 D3 Početak 81,530,999 bp Kraj 81,584,221 bp
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • microtubule binding • vezivanje tubulina • growth factor activity Ćelijska komponenta • citoplazma • citosol • jedro • nukleoplazma • extracellular region Biološki proces • negative regulation of microtubule depolymerization • microtubule polymerization • Ćelijska proliferacija • neuron projection development • regulation of signaling receptor activity • GO:0072468 Transdukcija signala Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	50810	29877
Ensembl	ENSG00000166503	ENSMUSG00000025104
UniProt	Q9Y3E1	Q9JMG7
RefSeq (mRNK)	NM_016073	NM_013886
RefSeq (bjelančevina)	NP_057157	NP_038914
Lokacija (UCSC)	Chr 15: 83.11 – 83.21 Mb	Chr 7: 81.53 – 81.58 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 203 aminokiseline, a molekulska težina 22.620 Da..

10		20		30		40		50
MARPRPREYK		AGDLVFAKMK		GYPHWPARID		ELPEGAVKPP		ANKYPIFFFG
THETAFLGPK		DLFPYKEYKD		KFGKSNKRKG		FNEGLWEIEN		NPGVKFTGYQ
AIQQQSSSET		EGEGGNTADA		SSEEEGDRVE		EDGKGKRKNE		KAGSKRKKSY
TSKKSSKQSR		KSPGDEDDKD		CKEEENKSSS		EGGDAGNDTR		NTTSDLQKTS
EGT

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

Dopunska literatura

• Vandegraaff N, Devroe E, Turlure F, et al. (2006). "Biochemical and genetic analyses of integrase-interacting proteins lens epithelium-derived growth factor (LEDGF)/p75 and hepatoma-derived growth factor related protein 2 (HRP2) in preintegration complex function and HIV-1 replication". Virology. 346 (2): 415–26. doi:10.1016/j.virol.2005.11.022. PMID 16337983.
• Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. doi:10.1126/science.1105776. PMID 15761153.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Cherepanov P, Devroe E, Silver PA, Engelman A (2005). "Identification of an evolutionarily conserved domain in human lens epithelium-derived growth factor/transcriptional co-activator p75 (LEDGF/p75) that binds HIV-1 integrase". J. Biol. Chem. 279 (47): 48883–92. doi:10.1074/jbc.M406307200. PMID 15371438.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Lai CH, Chou CY, Ch'ang LY, et al. (2000). "Identification of Novel Human Genes Evolutionarily Conserved in Caenorhabditis elegans by Comparative Proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
• Ikegame K, Yamamoto M, Kishima Y, et al. (2000). "A new member of a hepatoma-derived growth factor gene family can translocate to the nucleus". Biochem. Biophys. Res. Commun. 266 (1): 81–7. doi:10.1006/bbrc.1999.1733. PMID 10581169.