GTF2A1L
TFIIA-alfa i betoliki faktor jest protein koji je kod ljudi kodiran genom GTF2A1L sa hromosoma 2.[4][5][6][7]
| GTF2A1L | |||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||||||||||||||||||
| Aliasi | GTF2A1L | ||||||||||||||||||||||||
| Vanjski ID-jevi | OMIM: 605358 MGI: 1919078 HomoloGene: 86732 GeneCards: GTF2A1L | ||||||||||||||||||||||||
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| Ortolozi | |||||||||||||||||||||||||
| Vrste | Čovjek | Miš | |||||||||||||||||||||||
| Entrez | |||||||||||||||||||||||||
| Ensembl |
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| UniProt | |||||||||||||||||||||||||
| RefSeq (mRNK) | |||||||||||||||||||||||||
| RefSeq (bjelančevina) | |||||||||||||||||||||||||
| Lokacija (UCSC) | n/a | Chr 17: 88.98 – 89.02 Mb | |||||||||||||||||||||||
| PubMed pretraga | [2] | [3] | |||||||||||||||||||||||
| Wikipodaci | |||||||||||||||||||||||||
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Amiokiselininska sekvenca
urediDužina polipeptidnog lanca je 478 aminokiselina, a molkekulska iežina 52.444 Da.[8]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MACLNPVPKL | YRSVIEDVIE | GVRNLFAEEG | IEEQVLKDLK | QLWETKVLQS | ||||
| KATEDFFRNS | IQSPLFTLQL | PHSLHQTLQS | STASLVIPAG | RTLPSFTTAE | ||||
| LGTSNSSANF | TFPGYPIHVP | AGVTLQTVSG | HLYKVNVPIM | VTETSGRAGI | ||||
| LQHPIQQVFQ | QLGQPSVIQT | SVPQLNPWSL | QATTEKSQRI | ETVLQQPAIL | ||||
| PSGPVDRKHL | ENATSDILVS | PGNEHKIVPE | ALLCHQESSH | YISLPGVVFS | ||||
| PQVSQTNSNV | ESVLSGSASM | AQNLHDESLS | TSPHGALHQH | VTDIQLHILK | ||||
| NRMYGCDSVK | QPRNIEEPSN | IPVSEKDSNS | QVDLSIRVTD | DDIGEIIQVD | ||||
| GSGDTSSNEE | IGSTRDADEN | EFLGNIDGGD | LKVPEEEADS | ISNEDSATNS | ||||
| SDNEDPQVNI | VEEDPLNSGD | DVSEQDVPDL | FDTDNVIVCQ | YDKIHRSKNK | ||||
| WKFYLKDGVM | CFGGRDYVFA | KAIGDAEW |
Funkcija
urediSklapanje i stabilnost kompleksa preinicijacije transkripcije RNK-polimeraze II na promotoru eukariotskog jedra uključuje efekte TFIIA na interakciju između TATA-vezivanja proteina (TBP) i DNK.
Ovaj gen kodira pandan koji je specifičan za zametnu ćeliju velike (alfa/beta) podjedinice općeg transkripcionog faktora TFIIA koji je u stanju da stabilizuje vezivanje TBP za DNK i može biti jedinstveno važan za biologiju sjemenika. Uočeno je da alternativna prerada za ovaj lokus daje dvije varijante transkripta, koje kodiraju različite izoforme.
Kotranskripcija ovog gena i susjednog uzvodnog gena stvara rijetki transkript (SALF), koji kodira fuzijski protein koji se sastoji od sekvence koja dijeli identitet sa svakim pojedinačnim genskim proizvodom.[7]
Reference
uredi- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024154 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Upadhyaya AB, Lee SH, DeJong J (Jul 1999). "Identification of a general transcription factor TFIIAalpha/beta homolog selectively expressed in testis". J Biol Chem. 274 (25): 18040–8. doi:10.1074/jbc.274.25.18040. PMID 10364255.
- ^ Xie W, Han S, Khan M, DeJong J (maj 2002). "Regulation of ALF gene expression in somatic and male germ line tissues involves partial and site-specific patterns of methylation". J Biol Chem. 277 (20): 17765–74. doi:10.1074/jbc.M200954200. PMID 11889132.
- ^ Huang M, Wang H, Li J, Zhou Z, Du Y, Lin M, Sha J (Mar 2006). "Involvement of ALF in human spermatogenesis and male infertility". Int J Mol Med. 17 (4): 599–604. doi:10.3892/ijmm.17.4.599. PMID 16525715.
- ^ a b "Entrez Gene: ALF TFIIA-alpha/beta-like factor".
- ^ "UniProt, Q9UNN4" (jezik: engleski). Pristupljeno 12. 11. 2021.
Dopunska literatura
uredi- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Loveys DA, Streiff MB, Kato GJ (1996). "E2A basic-helix-loop-helix transcription factors are negatively regulated by serum growth factors and by the Id3 protein". Nucleic Acids Res. 24 (14): 2813–20. doi:10.1093/nar/24.14.2813. PMC 145994. PMID 8759016.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Malik S, Guermah M, Roeder RG (1998). "A dynamic model for PC4 coactivator function in RNA polymerase II transcription". Proc. Natl. Acad. Sci. U.S.A. 95 (5): 2192–7. Bibcode:1998PNAS...95.2192M. doi:10.1073/pnas.95.5.2192. PMC 19292. PMID 9482861.
- Han SY, Zhou L, Upadhyaya A, et al. (2001). "TFIIAalpha/beta-like factor is encoded by a germ cell-specific gene whose expression is up-regulated with other general transcription factors during spermatogenesis in the mouse". Biol. Reprod. 64 (2): 507–17. doi:10.1095/biolreprod64.2.507. PMID 11159353.
- Yoshida S, Ohbo K, Takakura A, et al. (2002). "Sgn1, a basic helix-loop-helix transcription factor delineates the salivary gland duct cell lineage in mice". Dev. Biol. 240 (2): 517–30. doi:10.1006/dbio.2001.0473. PMID 11784080.
- Upadhyaya AB, Khan M, Mou TC, et al. (2002). "The germ cell-specific transcription factor ALF. Structural properties and stabilization of the TATA-binding protein (TBP)-DNA complex". J. Biol. Chem. 277 (37): 34208–16. doi:10.1074/jbc.M204808200. PMID 12107178.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
- Howe ML, Mehmud ZF, Saha S, et al. (2006). "Transcription Factor IIA tau is associated with undifferentiated cells and its gene expression is repressed in primary neurons at the chromatin level in vivo". Stem Cells Dev. 15 (2): 175–90. doi:10.1089/scd.2006.15.175. PMID 16646664.
- Kim M, Li D, Cui Y, et al. (2006). "Regulatory factor interactions and somatic silencing of the germ cell-specific ALF gene". J. Biol. Chem. 281 (45): 34288–98. doi:10.1074/jbc.M607168200. PMID 16966320.