Gazdermin C je protein koji je kod ljudi kodiran genom GSDMC. [4]

GSDMC
Identifikatori
AliasiGSDMC
Vanjski ID-jeviOMIM: 608384 MGI: 2146102 HomoloGene: 69487 GeneCards: GSDMC
Lokacija gena (miš)
Hromosom 15 (miš)
Hrom.Hromosom 15 (miš)[1]
Hromosom 15 (miš)
Genomska lokacija za GSDMC
Genomska lokacija za GSDMC
Bend15|15 D1Početak63,696,195 bp[1]
Kraj63,717,026 bp[1]
Ontologija gena
Molekularna funkcija molekularna funkcija
phosphatidylserine binding
phosphatidylinositol-4,5-bisphosphate binding
phosphatidylinositol-4-phosphate binding
Ćelijska komponenta citoplazma
mitohondrija
centar organizacije mikrotubula
citosol
ćelijska membrana
membrana
Biološki proces GO:0010703, GO:0010702 programirana ćelijska smrt
GO:0022610 biološki proces
Piroptoza
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_031415

NM_001168274
NM_177912

RefSeq (bjelančevina)

NP_113603

NP_001161746
NP_808580

Lokacija (UCSC)n/aChr 15: 63.7 – 63.72 Mb
PubMed pretraga[2][3]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Aminokiselinska sekvenca

uredi

Dužina polipeptidnog lanca je 508 aminokiselina, а molekulska težina 57.692 Da.[5]

1020304050
MPSMLERISKNLVKEIGSKDLTPVKYLLSATKLRQFVILRKKKDSRSSFW
EQSDYVPVEFSLNDILEPSSSVLETVVTGPFHFSDIMIQKHKADMGVNVG
IEVSVSGEASVDHGCSLEFQIVTIPSPNLEDFQKRKLLDPEPSFLKECRR
RGDNLYVVTEAVELINNTVLYDSSSVNILGKIALWITYGKGQGQGESLRV
KKKALTLQKGMVMAYKRKQLVIKEKAILISDDDEQRTFQDEYEISEMVGY
CAARSEGLLPSFHTISPTLFNASSNDMKLKPELFLTQQFLSGHLPKYEQV
HILPVGRIEEPFWQNFKHLQEEVFQKIKTLAQLSKDVQDVMFYSILAMLR
DRGALQDLMNMLELDSSGHLDGPGGAILKKLQQDSNHAWFNPKDPILYLL
EAIMVLSDFQHDLLACSMEKRILLQQQELVRSILEPNFRYPWSIPFTLKP
ELLAPLQSEGLAITYGLLEECGLRMELDNPRSTWDVEAKMPLSALYGTLS
LLQQLAEA

Reference

uredi
  1. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000056293 - Ensembl, maj 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Entrez Gene: Gasdermin C". Pristupljeno 26. 8. 2016.
  5. ^ "UniProt, Q9BYG8" (jezik: engleski). Pristupljeno 18. 9. 2021.

Dopunska literatura

uredi
  • Saeki N, Usui T, Aoyagi K, Kim DH, Sato M, Mabuchi T, Yanagihara K, Ogawa K, Sakamoto H, Yoshida T, Sasaki H (2009). "Distinctive expression and function of four GSDM family genes (GSDMA-D) in normal and malignant upper gastrointestinal epithelium". Genes Chromosomes Cancer. 48 (3): 261–71. doi:10.1002/gcc.20636. PMID 19051310. S2CID 19705164.