GPHA2
Glikoproteinski hormon alfa-2 je protein koji je kod ljudi kodiran genom GPHA2.[5][6]
GPHA2 je polipeptid koji formira cistinski čvor i podjedinica je iz porodice dimernih glikoproteinskih hormona (Hsu et al., 2002, prema OMIM).[6]
Aminokiselinska sekvenca
urediDužina polipeptidnog lanca je 129 aminokiselina, a molekulska težina 14.163 Da.[7]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MPMASPQTLV | LYLLVLAVTE | AWGQEAVIPG | CHLHPFNVTV | RSDRQGTCQG | ||||
| SHVAQACVGH | CESSAFPSRY | SVLVASGYRH | NITSVSQCCT | ISGLKKVKVQ | ||||
| LQCVGSRREE | LEIFTARACQ | CDMCRLSRY |
Reference
uredi- ^ a b c GRCh38: Ensembl release 89: ENSG00000149735 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024784 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Hsu SY, Nakabayashi K, Nishi S, Kumagai J, Kudo M, Sherwood OD, Hsueh AJ (Jan 2002). "Activation of orphan receptors by the hormone relaxin". Science. 295 (5555): 671–4. doi:10.1126/science.1065654. PMID 11809971. S2CID 32693420.
- ^ a b "Entrez Gene: GPHA2 glycoprotein hormone alpha 2".
- ^ "UniProt, Q96T91". Pristupljeno 22. 8. 2021.
Dopunska literatura
uredi- Suzuki C, Nagasaki H, Okajima Y, et al. (2007). "The LIM domain homeobox gene isl-1 is a positive regulator of glycoprotein alpha 2 (GPA2), a subunit of thyrostimulin". Regul. Pept. 142 (1–2): 60–7. doi:10.1016/j.regpep.2007.01.009. PMID 17363077. S2CID 24382046.
- Breous E, Wenzel A, Loos U (2006). "Promoter cloning and characterisation of the transcriptional regulation of the human thyrostimulin A2 subunit". Mol. Cell. Endocrinol. 245 (1–2): 169–80. doi:10.1016/j.mce.2005.11.009. PMID 16376481. S2CID 21211666.
- Sudo S, Kuwabara Y, Park JI, et al. (2005). "Heterodimeric fly glycoprotein hormone-alpha2 (GPA2) and glycoprotein hormone-beta5 (GPB5) activate fly leucine-rich repeat-containing G protein-coupled receptor-1 (DLGR1) and stimulation of human thyrotropin receptors by chimeric fly GPA2 and human GPB5". Endocrinology. 146 (8): 3596–604. doi:10.1210/en.2005-0317. PMID 15890769.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Hsu SY, Nakabayashi K, Bhalla A (2003). "Evolution of glycoprotein hormone subunit genes in bilateral metazoa: identification of two novel human glycoprotein hormone subunit family genes, GPA2 and GPB5". Mol. Endocrinol. 16 (7): 1538–51. doi:10.1210/me.16.7.1538. PMID 12089349.
- Nakabayashi K, Matsumi H, Bhalla A, et al. (2002). "Thyrostimulin, a heterodimer of two new human glycoprotein hormone subunits, activates the thyroid-stimulating hormone receptor". J. Clin. Invest. 109 (11): 1445–52. doi:10.1172/JCI14340. PMC 150994. PMID 12045258.