GLTSCR2

GLTSCR2
Identifikatori
Aliasi	NOP53
Vanjski ID-jevi	OMIM: 605691 MGI: 2154441 HomoloGene: 44130 GeneCards: NOP53
Lokacija gena (čovjek)
Hrom.	Hromosom 19 (čovjek)
Kraj	47,757,058 bp
Lokacija gena (miš)
Hrom.	Hromosom 7 (miš)
Kraj	15,679,999 bp
Ontologija gena
Molekularna funkcija	• vezivanje sa RNK; • 5S rRNA binding; • GO:0001948, GO:0016582 vezivanje za proteine; • p53 binding; • vezivanje identičnih proteina;
Ćelijska komponenta	• intracellular anatomical structure; • intracellular membrane-bounded organelle; • jedro; • Jedarce; • citosol; • fibrillar center; • rDNA heterochromatin; • nukleoplazma;
Biološki proces	• ribosomal large subunit assembly; • regulation of protein phosphorylation; • protein stabilization; • regulation of signal transduction by p53 class mediator; • negative regulation of signal transduction by p53 class mediator; • regulation of aerobic respiration; • ribosomal large subunit export from nucleus; • GO:1901227 negative regulation of transcription by RNA polymerase II; • GO:0100026 Popravka DNK; • mitotic G2 DNA damage checkpoint signaling; • negative regulation of phosphatidylinositol 3-kinase signaling; • GO:0106160 negative regulation of protein-containing complex assembly; • negative regulation of proteasomal ubiquitin-dependent protein catabolic process; • positive regulation of proteasomal ubiquitin-dependent protein catabolic process; • regulation of apoptotic process; • regulation of cell cycle; • cellular response to hypoxia; • protein localization to nucleolus; • protein localization to nucleoplasm; • cellular response to DNA damage stimulus; • regulation of RIG-I signaling pathway; • negative regulation of protein kinase B signaling; • negative regulation of transcription of nucleolar large rRNA by RNA polymerase I; • positive regulation of protein K63-linked deubiquitination; • ribosome biogenesis; • rRNA processing;
	Izvori:Amigo / QuickGO
Ortolozi
	29997
	68077
	ENSG00000105373
	ENSMUSG00000041560
	Q9NZM5
	Q8BK35
	NM_015710
	NM_133831
	NP_056525
	NP_598592
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Proteinski kandidat regije gena-2 gliomskog supresora je protein koji je kod ljudi kodiran genom GLTSCR2.^[5]^[6]^[7]^[8]

Aminokiselinska sekcenca

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

10	20	30	40	50
MAAGGSGVGG	KRSSKSDADS	GFLGLRPTSV	DPALRRRRRG	PRNKKRGWRR
LAQEPLGLEV	DQFLEDVRLQ	ERTSGGLLSE	APNEKLFFVD	TGSKEKGLTK
KRTKVQKKSL	LLKKPLRVDL	ILENTSKVPA	PKDVLAHQVP	NAKKLRRKEQ
LWEKLAKQGE	LPREVRRAQA	RLLNPSATRA	KPGPQDTVER	PFYDLWASDN
PLDRPLVGQD	EFFLEQTKKK	GVKRPARLHT	KPSQAPAVEV	APAGASYNPS
FEDHQTLLSA	AHEVELQRQK	EAEKLERQLA	LPATEQAATQ	ESTFQELCEG
LLEESDGEGE	PGQGEGPEAG	DAEVCPTPAR	LATTEKKTEQ	QRRREKAVHR
LRVQQAALRA	ARLRHQELFR	LRGIKAQVAL	RLAELARRQR	RRQARREAEA
DKPRRLGRLK	YQAPDIDVQL	SSELTDSLRT	LKPEGNILRD	RFKSFQRRNM
IEPRERAKFK	RKYKVKLVEK	RAFREIQL

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000105373 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000041560 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Smith JS, Tachibana I, Pohl U, Lee HK, Thanarajasingam U, Portier BP, Ueki K, Ramaswamy S, Billings SJ, Mohrenweiser HW, Louis DN, Jenkins RB (Jun 2000). "A transcript map of the chromosome 19q-arm glioma tumor suppressor region". Genomics. 64 (1): 44–50. doi:10.1006/geno.1999.6101. PMID 10708517.
^ Okahara F, Itoh K, Nakagawara A, Murakami M, Kanaho Y, Maehama T (Oct 2006). "Critical role of PICT-1, a tumor suppressor candidate, in phosphatidylinositol 3,4,5-trisphosphate signals and tumorigenic transformation". Mol Biol Cell. 17 (11): 4888–95. doi:10.1091/mbc.E06-04-0301. PMC 1635402. PMID 16971513.
^ Yim JH, Kim YJ, Ko JH, Cho YE, Kim SM, Kim JY, Lee S, Park JH (Oct 2007). "The putative tumor suppressor gene GLTSCR2 induces PTEN-modulated cell death". Cell Death Differ. 14 (11): 1872–9. doi:10.1038/sj.cdd.4402204. PMID 17657248.
^ "Entrez Gene: GLTSCR2 glioma tumor suppressor candidate region gene 2".

Dopunska literatura

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Bruni R, Fineschi B, Ogle WO, Roizman B (1999). "A novel cellular protein, p60, interacting with both herpes simplex virus 1 regulatory proteins ICP22 and ICP0 is modified in a cell-type-specific manner and Is recruited to the nucleus after infection". J. Virol. 73 (5): 3810–7. doi:10.1128/JVI.73.5.3810-3817.1999. PMC 104158. PMID 10196275.
Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
Scherl A, Couté Y, Déon C, et al. (2003). "Functional proteomic analysis of human nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Okahara F, Ikawa H, Kanaho Y, Maehama T (2004). "Regulation of PTEN phosphorylation and stability by a tumor suppressor candidate protein". J. Biol. Chem. 279 (44): 45300–3. doi:10.1074/jbc.C400377200. PMID 15355975.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
Yim JH, Kim YJ, Cho YE, et al. (2007). "GLTSCR2 sensitizes cells to hypoxic injury without involvement of mitochondrial apoptotic cascades". Pathobiology. 74 (5): 301–8. doi:10.1159/000105813. PMID 17890897.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000105373 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000041560 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10708517-5] Smith JS, Tachibana I, Pohl U, Lee HK, Thanarajasingam U, Portier BP, Ueki K, Ramaswamy S, Billings SJ, Mohrenweiser HW, Louis DN, Jenkins RB (Jun 2000). "A transcript map of the chromosome 19q-arm glioma tumor suppressor region". Genomics. 64 (1): 44–50. doi:10.1006/geno.1999.6101. PMID 10708517.

[pmid16971513-6] Okahara F, Itoh K, Nakagawara A, Murakami M, Kanaho Y, Maehama T (Oct 2006). "Critical role of PICT-1, a tumor suppressor candidate, in phosphatidylinositol 3,4,5-trisphosphate signals and tumorigenic transformation". Mol Biol Cell. 17 (11): 4888–95. doi:10.1091/mbc.E06-04-0301. PMC 1635402. PMID 16971513.

[pmid17657248-7] Yim JH, Kim YJ, Ko JH, Cho YE, Kim SM, Kim JY, Lee S, Park JH (Oct 2007). "The putative tumor suppressor gene GLTSCR2 induces PTEN-modulated cell death". Cell Death Differ. 14 (11): 1872–9. doi:10.1038/sj.cdd.4402204. PMID 17657248.

[entrez-8] "Entrez Gene: GLTSCR2 glioma tumor suppressor candidate region gene 2".

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