FTSJ3

Putativna rRNK metiltransferaza 3 je enzim koji je kod ljudi kodiran genom FTSJ3.

FTSJ3
Identifikatori
Aliasi	FTSJ3
Vanjski ID-jevi	OMIM: 618411 MGI: 1860295 HomoloGene: 5451 GeneCards: FTSJ3
Lokacija gena (čovjek) Hrom. Hromosom 17 (čovjek) Bend 17q23.3 Početak 63,819,433 bp Kraj 63,830,012 bp
Lokacija gena (miš) Hrom. Hromosom 11 (miš) Bend 11 E1|11 68.89 cM Početak 106,139,968 bp Kraj 106,146,905 bp
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • GO:0102674, GO:0102675 methyltransferase activity • aktivnost sa transferazom • rRNA methyltransferase activity • GO:0001948, GO:0016582 vezivanje za proteine • vezivanje sa RNK • rRNA (uridine-2'-O-)-methyltransferase activity • rRNA (guanine) methyltransferase activity Ćelijska komponenta • jedro • Jedarce • preribosome, large subunit precursor • preribosome, small subunit precursor Biološki proces • rRNA processing • Metilacija • RNA methylation • ribosome biogenesis • maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) • maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) • rRNA methylation • enzyme-directed rRNA 2'-O-methylation Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	117246	56095
Ensembl	ENSG00000108592	ENSMUSG00000020706
UniProt	Q8IY81	Q9DBE9
RefSeq (mRNK)	NM_017647	NM_025310
RefSeq (bjelančevina)	NP_060117	NP_079586
Lokacija (UCSC)	Chr 17: 63.82 – 63.83 Mb	Chr 11: 106.14 – 106.15 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Iako funkcija ovog gena nije poznata, njegovo postojanje potkrepljeno je podacima o iRNK i EST-u. O mogućoj funkciji kodiranog proteina može se zaključiti na osnovu sličnosti aminokiselinskih sekvenci s proteinima FtsJ E. coli i mišjim proteinom koji je možda uključen u embriogenezu.

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 847 aminokiselina, a molekulska težina 96.558 Da.

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

10		20		30		40		50
MGKKGKVGKS		RRDKFYHLAK		ETGYRSRSAF		KLIQLNRRFQ		FLQKARALLD
LCAAPGGWLQ		VAAKFMPVSS		LIVGVDLVPI		KPLPNVVTLQ		QDITTERCRQ
ALRKELKTWK		VDVVLNDGAP		NVGASWVHDA		YSQAHLTLMA		LRLACDFLAR
GGSFITKVFR		SRDYQPLLWI		FQQLFRRVQA		TKPQASRHES		AEIFVVCQGF
LAPDKVDSKF		FDPKFAFKEV		EVQAKTVTEL		VTKKKPKAEG		YAEGDLTLYH
RTSVTDFLRA		ANPVDFLSKA		SEIMVDDEEL		AQHPATTEDI		RVCCQDIRVL
GRKELRSLLN		WRTKLRRYVA		KKLKEQAKAL		DISLSSGEED		EGDEEDSTAG
TTKQPSKEEE		EEEEEEQLNQ		TLAEMKAQEV		AELKRKKKKL		LREQRKQRER
VELKMDLPGV		SIADEGETGM		FSLSTIRGHQ		LLEEVTQGDM		SAADTFLSDL
PRDDIYVSDV		EDDGDDTSLD		SDLDPEELAG		VRGHQGLRDQ		KRMRLTEVQD
DKEEEEEENP		LLVPLEEKAV		LQEEQANLWF		SKGSFAGIED		DADEALEISQ
AQLLFENRRK		GRQQQQKQQL		PQTPPSCLKT		EIMSPLYQDE		APKGTEASSG
TEAATGLEGE		EKDGISDSDS		STSSEEEESW		EPLRGKKRSR		GPKSDDDGFE
IVPIEDPAKH		RILDPEGLAL		GAVIASSKKA		KRDLIDNSFN		RYTFNEDEGE
LPEWFVQEEK		QHRIRQLPVG		KKEVEHYRKR		WREINARPIK		KVAEAKARKK
RRMLKRLEQT		RKKAEAVVNT		VDISEREKVA		QLRSLYKKAG		LGKEKRHVTY
VVAKKGVGRK		VRRPAGVRGH		FKVVDSRMKK		DQRAQQRKEQ		KKKHKRK

Dopunska literatura

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• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.