FBXO9
Jedini F-kutijski protein 9 jest protein koji je kod ljudi kodiran genom FBXO9.[5][6][7]
Aminokiselinska sekvenca
urediDužina polipeptidnog lanca je 447 aminokiselina, а molekulska težina 52.329 Da.[8]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MPDIIWVFPP | QAEAEEDCHS | DTVRADDDEE | NESPAETDLQ | AQLQMFRAQW | ||||
| MFELAPGVSS | SNLENRPCRA | ARGSLQKTSA | DTKGKQEQAK | EEKARELFLK | ||||
| AVEEEQNGAL | YEAIKFYRRA | MQLVPDIEFK | ITYTRSPDGD | GVGNSYIEDN | ||||
| DDDSKMADLL | SYFQQQLTFQ | ESVLKLCQPE | LESSQIHISV | LPMEVLMYIF | ||||
| RWVVSSDLDL | RSLEQLSLVC | RGFYICARDP | EIWRLACLKV | WGRSCIKLVP | ||||
| YTSWREMFLE | RPRVRFDGVY | ISKTTYIRQG | EQSLDGFYRA | WHQVEYYRYI | ||||
| RFFPDGHVMM | LTTPEEPQSI | VPRLRTRNTR | TDAILLGHYR | LSQDTDNQTK | ||||
| VFAVITKKKE | EKPLDYKYRY | FRRVPVQEAD | QSFHVGLQLC | SSGHQRFNKL | ||||
| IWIHHSCHIT | YKSTGETAVS | AFEIDKMYTP | LFFARVRSYT | AFSERPL |
Funkcija
urediOvaj gen kodira člana F-kutije porodice proteina koju karakterizira približno 40-aminokiselinski motiv F-kutija. Proteini F-kutije čine jednu od četiri podjedinice kompleksa proteinske ubikvitin-ligaze zvane SCF (SKP1-kulin-F-kutija), koje funkcioniraju u ubikvitinaciji zavisnoj o fosforilaciji. Proteini F-kutije podijeljeni su u tri klase: Fbws koji sadrže domene WD-40, Fbls sa ponavljanjima bogatim leucinom, i Fbxs koji sadrže ili različite module interakcije protein-protein ili ne prepoznaju motive. Protein kodiran ovim genom pripada klasi Fbx. Alternativna prerada ovog gena stvara najmanje tri varijante transkripta koje se razlikuju na 5' terminalu.[7]
Reference
uredi- ^ a b c GRCh38: Ensembl release 89: ENSG00000112146 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000001366 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (Dec 1999). "Identification of a family of human F-box proteins". Curr Biol. 9 (20): 1177–9. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035. S2CID 7467493.
- ^ Winston JT, Koepp DM, Zhu C, Elledge SJ, Harper JW (Dec 1999). "A family of mammalian F-box proteins". Curr Biol. 9 (20): 1180–2. doi:10.1016/S0960-9822(00)80021-4. PMID 10531037. S2CID 14341845.
- ^ a b "Entrez Gene: FBXO9 F-box protein 9".
- ^ "UniProt, Q9UK97" (jezik: engleski). Pristupljeno 2. 10. 2021.
Dopunska literatura
uredi- Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
- Scanlan MJ, Gordan JD, Williamson B, et al. (1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma". Int. J. Cancer. 83 (4): 456–64. doi:10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5. PMID 10508479.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Jin J, Cardozo T, Lovering RC, et al. (2005). "Systematic analysis and nomenclature of mammalian F-box proteins". Genes Dev. 18 (21): 2573–80. doi:10.1101/gad.1255304. PMC 525538. PMID 15520277.